Chapter 24 | Endocrine Functions of the Pancreas
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Questions and Answers

What is one of the rapid actions of insulin according to the text?

  • Inhibition of protein degradation
  • Activation of glycolytic enzymes (correct)
  • Increase in mRNAs for lipogenic enzymes
  • Stimulation of protein synthesis

Which tissue shows an increase in glucose entry, fatty acid synthesis, and triglyceride deposition due to insulin?

  • Skeletal muscle
  • Adipose tissue (correct)
  • Liver
  • Cardiac muscle

What effect does insulin have on glycogen synthesis in muscle?

  • No effect on glycogen synthesis
  • Decrease glycogen synthesis
  • Increase glycogen synthesis (correct)
  • Promote breakdown of glycogen

Which enzyme is inhibited by insulin according to the text?

<p>Phosphorylase (C)</p> Signup and view all the answers

What is the effect of insulin on protein catabolism in muscle?

<p><strong>Decrease</strong> protein catabolism (C)</p> Signup and view all the answers

Which process does insulin activate in adipose tissue?

<p><strong>Increase</strong> glucose entry (C)</p> Signup and view all the answers

What is a common symptom of diabetes?

<p>Polydipsia (C)</p> Signup and view all the answers

Which of the following happens in diabetes due to reduced entry of glucose into peripheral tissues?

<p>Hyperglycemia (D)</p> Signup and view all the answers

What is a potential complication of long-standing diabetes involving retinal scarring?

<p>Diabetic retinopathy (D)</p> Signup and view all the answers

Which of the following is a microvascular complication of diabetes?

<p>Diabetic nephropathy (A)</p> Signup and view all the answers

What contributes to the macrovascular abnormalities in diabetes?

<p>Accelerated atherosclerosis (D)</p> Signup and view all the answers

What type of abnormalities does diabetic neuropathy involve?

<p>Autonomic nervous system and peripheral nerve abnormalities (D)</p> Signup and view all the answers

Which substance inhibits the secretion of insulin in the pancreas?

<p>Somatostatin (C)</p> Signup and view all the answers

What can cause selective destruction of the B cells of the pancreatic islets?

<p>Pancreatectomy (A)</p> Signup and view all the answers

What effect does SS 28 have on insulin secretion?

<p>Inhibits insulin secretion (A)</p> Signup and view all the answers

Which of the following is a stimulator of insulin secretion?

<p>β-Keto acids (B)</p> Signup and view all the answers

What is a symptom that can result from hyperglycemia?

<p>Polyuria (A)</p> Signup and view all the answers

What hormone is found in the D cells of pancreatic islets and inhibits the secretion of insulin?

<p>Somatostatin (C)</p> Signup and view all the answers

What is measured clinically as an integrated index of diabetic control?

<p>Hemoglobin A1c concentration (D)</p> Signup and view all the answers

Which of the following substances increases the secretion of somatostatin in the pancreas?

<p>Glucose (C)</p> Signup and view all the answers

In diabetes, what happens to the rate at which amino acids are catabolized?

<p>Increases (D)</p> Signup and view all the answers

What leads to polydipsia in cases of hyperglycemia?

<p>Dehydration (C)</p> Signup and view all the answers

What role does SS 14 play in the pancreas?

<p>Inhibits insulin, glucagon, and pancreatic polypeptide secretion (D)</p> Signup and view all the answers

Why is there glycosuria in cases of hyperglycemia?

<p>Excess glucose for renal reabsorption (A)</p> Signup and view all the answers

What is the primary cause of clinical diabetes according to the text?

<p>Autoimmune destruction of B cells in the pancreas (C)</p> Signup and view all the answers

What distinguishes type 1 diabetes mellitus from type 2 diabetes mellitus?

<p>Autoimmune destruction of B cells (B)</p> Signup and view all the answers

Which ancient term was used to describe conditions with a large urine volume, one type being sweet-tasting urine?

<p>Diabetes mellitus (C)</p> Signup and view all the answers

What type of diabetes is characterized by dysregulation of insulin release and insulin resistance in peripheral tissues?

<p>Type 2 diabetes (C)</p> Signup and view all the answers

Which type of diabetes usually presents in children?

<p>Type 1 diabetes (D)</p> Signup and view all the answers

What is the defining characteristic of 'diabetes mellitus' according to the text?

<p>Sweet-tasting urine (D)</p> Signup and view all the answers

What is the primary function of insulin in regulating metabolism?

<p>Promoting glucose uptake into cells (A)</p> Signup and view all the answers

Which of the following is a hormone secreted by the pancreas that regulates ion transport in the intestine?

<p>Pancreatic polypeptide (D)</p> Signup and view all the answers

Which type of cells in the islets of Langerhans are also known as δ cells?

<p>D cells (B)</p> Signup and view all the answers

What is the role of somatostatin in islet cell secretion regulation?

<p>Inhibiting glucagon secretion (B)</p> Signup and view all the answers

Which hormone plays a crucial role in regulating the intermediary metabolism of carbohydrates, proteins, and fats?

<p>Insulin (C)</p> Signup and view all the answers

What is the function of glucagon in the regulation of metabolism?

<p>Accelerating glycogen breakdown (D)</p> Signup and view all the answers

What is the effect of insulin on ketogenesis in the liver?

<p>Decreased (B)</p> Signup and view all the answers

Which of the following is NOT an effect of insulin on muscle tissue?

<p>Increased ketone uptake (C)</p> Signup and view all the answers

What is the primary effect of insulin on glucose transporters in cells?

<p>Increased K+ uptake (B)</p> Signup and view all the answers

What does insulin do to the release of gluconeogenic amino acids in muscle tissue?

<p>Decreases the release (B)</p> Signup and view all the answers

In which tissue does insulin play a role in the activation of lipoprotein lipase?

<p>Adipose tissue (B)</p> Signup and view all the answers

What effect does insulin have on fatty acid synthesis in the liver?

<p>Increases fatty acid synthesis (C)</p> Signup and view all the answers

What is the term used to describe the situation in diabetes where there is extracellular glucose excess and intracellular glucose deficiency?

<p>Starvation in the midst of plenty (C)</p> Signup and view all the answers

Microvascular abnormalities in diabetes include proliferative scarring of the retina leading to blindness. What is this condition called?

<p>Diabetic retinopathy (D)</p> Signup and view all the answers

What is the primary cause of macrovascular abnormalities in diabetes?

<p>Accelerated atherosclerosis (D)</p> Signup and view all the answers

In diabetic nephropathy, what complication can result from the renal disease associated with diabetes?

<p>Chronic kidney disease (B)</p> Signup and view all the answers

What type of nerves are involved in diabetic neuropathy?

<p>Autonomic nerves and peripheral nerves (C)</p> Signup and view all the answers

What is the term for the situation in diabetes where weight loss occurs despite increased appetite?

<p>Polyphagia (B)</p> Signup and view all the answers

Which of the following factors is known to inhibit the secretion of insulin in the pancreas?

<p>Somatostatin 14 (C)</p> Signup and view all the answers

What is the effect of α-Adrenergic stimulators on insulin secretion?

<p>Stimulation (A)</p> Signup and view all the answers

Which substance increases somatostatin secretion in the pancreas?

<p>CCK (D)</p> Signup and view all the answers

How does SS 28 differ from SS 14 in terms of inhibiting insulin secretion?

<p>SS 28 is more active (B)</p> Signup and view all the answers

Which factor stimulates insulin secretion and inhibits glucagon secretion?

<p>Intestinal hormones (C)</p> Signup and view all the answers

What is the primary role of somatostatin in pancreatic islets?

<p>Inhibiting insulin and glucagon secretion (D)</p> Signup and view all the answers

What is the fundamental defect in type 2 diabetes that most abnormalities can be traced back to?

<p>Reduced entry of glucose into peripheral tissues (D)</p> Signup and view all the answers

Which characteristic is not typically observed in a patient with diabetes?

<p>Weight gain (D)</p> Signup and view all the answers

What is the primary therapeutic approach in managing type 1 diabetes?

<p>Provision of exogenous insulin (D)</p> Signup and view all the answers

What is the main focus of lifestyle changes in early type 2 diabetes according to the text?

<p>Dietary alterations or increased exercise (A)</p> Signup and view all the answers

Which action characterizes insulin-sensitizing drugs in type 2 diabetes management?

<p>Enhancing glucose entry into peripheral tissues (A)</p> Signup and view all the answers

What paradoxical situation is described as 'starvation in the midst of plenty' in the context of type 2 diabetes?

<p>'Peripheral' tissues in a state of starvation despite high blood glucose levels (B)</p> Signup and view all the answers

What is the term used to describe the situation in diabetes where there is extracellular glucose excess and intracellular glucose deficiency?

<p>Starvation in the midst of plenty (D)</p> Signup and view all the answers

Which complication of diabetes involves proliferative scarring of the retina leading to blindness?

<p>Diabetic retinopathy (A)</p> Signup and view all the answers

What leads to weight loss in diabetes despite an increased appetite?

<p>Starvation in the midst of plenty (A)</p> Signup and view all the answers

Which type of disease is diabetic nephropathy?

<p>Microvascular disease (C)</p> Signup and view all the answers

What is the main cause of macrovascular abnormalities in diabetes according to the text?

<p>Increased plasma LDL (B)</p> Signup and view all the answers

Which condition results from renal disease associated with diabetes?

<p>Chronic kidney disease (A)</p> Signup and view all the answers

'Starvation in the midst of plenty' is primarily caused by what underlying defect in diabetes?

<p>Reduced entry of glucose into tissues (A)</p> Signup and view all the answers

What is the result of accelerated atherosclerosis in diabetes?

<p>Increased incidence of stroke (C)</p> Signup and view all the answers

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