Endocrine Physiology Lecture 11: Glucose Homeostasis II

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Questions and Answers

What stimulates the secretion of glucagon?

  • Insulin
  • Somatostatin
  • Hyperglycemia
  • Hypoglycemia (correct)

What is the effect of high concentrations of glucagon on the heart?

  • Chronotropic effect
  • Negative inotropic effect
  • Positive inotropic effect (correct)
  • No effect

What is the effect of glucagon on glycogen in the liver?

  • No effect
  • Increases glycogen storage
  • Stimulates glycogen synthesis
  • Breaks down glycogen to increase glucose levels (correct)

Why does a protein meal stimulate the secretion of both insulin and glucagon?

<p>To prevent hypoglycemia and allow amino acids to enter cells (D)</p> Signup and view all the answers

What is the effect of glucagon on lipolysis and ketone formation?

<p>Increases lipolysis and ketone formation (B)</p> Signup and view all the answers

What hormones may be involved in the glucagon response to oral administration of amino acids?

<p>CCK and gastrin (A)</p> Signup and view all the answers

What is the main characteristic of Type 1 diabetes?

<p>Destruction of the β-cells of the islets of Langerhans (D)</p> Signup and view all the answers

What is the typical age of onset for Type 1 diabetes?

<p>Teenage years (D)</p> Signup and view all the answers

What is the reason for normal plasma potassium levels in diabetic patients despite total body potassium deficiency?

<p>Potassium moves from cells to extracellular fluid when H+ concentration is high (A)</p> Signup and view all the answers

What is the primary cause of insulin resistance?

<p>Unclear, with multiple factors contributing (A)</p> Signup and view all the answers

What is a long-term consequence of uncontrolled diabetes?

<p>End-stage kidney disease (D)</p> Signup and view all the answers

What is the primary cause of β-cell destruction in Type 1 diabetes?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following is a characteristic of type 1 diabetes mellitus?

<p>Requires insulin injection for treatment (A)</p> Signup and view all the answers

What is a common complication of uncontrolled diabetes?

<p>Heart attack and stroke (B)</p> Signup and view all the answers

What is the most important risk factor for type 2 diabetes mellitus?

<p>Obesity (A)</p> Signup and view all the answers

What is released by intra-abdominal 'central' adipose tissue that competes with glucose as a fuel supply?

<p>Free fatty acids (A)</p> Signup and view all the answers

What is the primary function of somatostatin?

<p>To inhibit the secretion of both insulin and glucagon (D)</p> Signup and view all the answers

What type of amino acids are particularly stimulatory to glucagon secretion?

<p>Glucogenic amino acids (C)</p> Signup and view all the answers

What is a characteristic of metabolic syndrome?

<p>Fasting hyperglycemia (D)</p> Signup and view all the answers

Which of the following is a complication of type 1 diabetes mellitus?

<p>Impaired cardiovascular reflexes (B)</p> Signup and view all the answers

What is the effect of hyperglycemia on glucagon secretion?

<p>It inhibits glucagon secretion (B)</p> Signup and view all the answers

What is the primary effect of insulin deficiency in diabetes mellitus?

<p>Increased blood glucose concentration and decreased cell utilization of glucose (B)</p> Signup and view all the answers

What is the effect of glucagon on glucose metabolism?

<p>It decreases glucose uptake in cells (B)</p> Signup and view all the answers

What is the primary characteristic of type 1 diabetes mellitus?

<p>Insulin deficiency (A)</p> Signup and view all the answers

What is a consequence of inactivity on glucose metabolism?

<p>Down-regulation of insulin-sensitive kinases (C)</p> Signup and view all the answers

What is a cause of insulin resistance?

<p>Excess glucocorticoids (D)</p> Signup and view all the answers

What is associated with lipid accumulation in the liver?

<p>Lipodystrophy (A)</p> Signup and view all the answers

What is a consequence of insulin resistance in sedentary people?

<p>Increased insulin resistance (C)</p> Signup and view all the answers

What is associated with autoantibodies to the insulin receptor?

<p>Insulin resistance (C)</p> Signup and view all the answers

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