18 Questions
Which symptom is NOT commonly associated with Medullary thyroid carcinoma in patients with MEN Type 2A?
Memory problems
What is a common clinical manifestation of hypercalcemia due to Hyperparathyroidism in MEN Type 2A patients?
Constipation
Which of the following is a characteristic presentation of cutaneous lichen amyloidosis in multiple endocrine neoplasia type 2A?
Multiple pruritic, hyperpigmented, lichenoid papules in the scapular area of the back
What is a characteristic feature of neuromas in patients with MEN Type 2B?
Bumps around the lips, tongue, and mouth
How is screening for pheochromocytoma typically conducted in patients suspected of having multiple endocrine neoplasia type 2?
24-hour urine test for elevated catecholamines and catecholamine metabolites
In multiple endocrine neoplasia type 2, what does an abdominal MRI scan help to confirm?
Medullary thyroid carcinoma confirmation
What gene mutation is responsible for type 1 Multiple Endocrine Neoplasia?
MENIN
Which protein, produced by the MENIN gene, acts as a tumor suppressor?
Menin
What is the most common initial clinical manifestation of type 1 Multiple Endocrine Neoplasia?
Hyperparathyroidism
Which gene mutation is responsible for type 2 Multiple Endocrine Neoplasia?
RET
What is the location of the RET gene, responsible for type 2 Multiple Endocrine Neoplasia?
Chromosome 10q11.2
What kind of cells does RET lead to hyperplasia in, in type 2 Multiple Endocrine Neoplasia?
Target cells
What is the peak incidence age range for non-endocrine malignant tumors of the pancreas?
50-60 years old
Which of the following symptoms is NOT typically associated with malignant pancreatic tumors?
Chest pain
Where do 2/3 of ductal adenocarcinomas of the pancreas tend to be located?
Head of the pancreas
Which of the following is a hormone-secreting non-endocrine neoplasm of the pancreas?
Insulinoma
What is a common diagnostic tool used to confirm obstructive jaundice in patients with pancreatic tumors?
Liver function tests
What is a potential consequence of late-stage diagnosis in over 90% of pancreatic cancer patients?
No chance of cure
Explore the characteristics of less common endocrine tumors which are generally benign and sometimes multiple, including Insulinoma and Glucogonomas. Learn about other types such as Gastrinomas, Somatostatinomas, and Vipomas. Also, discover information about non-endocrine malignant tumors like Adenocarcinoma Of Pancreas.
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