Endocrine Neoplasms 1 Overview

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Questions and Answers

Which symptom is NOT commonly associated with Medullary thyroid carcinoma in patients with MEN Type 2A?

  • Diarrhea
  • Episodic sweating
  • Hypertension
  • Memory problems (correct)

What is a common clinical manifestation of hypercalcemia due to Hyperparathyroidism in MEN Type 2A patients?

  • Nephrolithiasis
  • Constipation (correct)
  • Depression
  • Polyuria

Which of the following is a characteristic presentation of cutaneous lichen amyloidosis in multiple endocrine neoplasia type 2A?

  • Multiple pruritic, hyperpigmented, lichenoid papules in the neck
  • Multiple pruritic, hyperpigmented, lichenoid papules in the scapular area of the back (correct)
  • Multiple pruritic, hyperpigmented, lichenoid papules in the limbs
  • Multiple pruritic, hyperpigmented, lichenoid papules in the abdomen

What is a characteristic feature of neuromas in patients with MEN Type 2B?

<p>Bumps around the lips, tongue, and mouth (C)</p> Signup and view all the answers

How is screening for pheochromocytoma typically conducted in patients suspected of having multiple endocrine neoplasia type 2?

<p>24-hour urine test for elevated catecholamines and catecholamine metabolites (A)</p> Signup and view all the answers

In multiple endocrine neoplasia type 2, what does an abdominal MRI scan help to confirm?

<p>Medullary thyroid carcinoma confirmation (B)</p> Signup and view all the answers

What gene mutation is responsible for type 1 Multiple Endocrine Neoplasia?

<p>MENIN (C)</p> Signup and view all the answers

Which protein, produced by the MENIN gene, acts as a tumor suppressor?

<p>Menin (B)</p> Signup and view all the answers

What is the most common initial clinical manifestation of type 1 Multiple Endocrine Neoplasia?

<p>Hyperparathyroidism (C)</p> Signup and view all the answers

Which gene mutation is responsible for type 2 Multiple Endocrine Neoplasia?

<p>RET (A)</p> Signup and view all the answers

What is the location of the RET gene, responsible for type 2 Multiple Endocrine Neoplasia?

<p>Chromosome 10q11.2 (C)</p> Signup and view all the answers

What kind of cells does RET lead to hyperplasia in, in type 2 Multiple Endocrine Neoplasia?

<p>Target cells (B)</p> Signup and view all the answers

What is the peak incidence age range for non-endocrine malignant tumors of the pancreas?

<p>50-60 years old (D)</p> Signup and view all the answers

Which of the following symptoms is NOT typically associated with malignant pancreatic tumors?

<p>Chest pain (B)</p> Signup and view all the answers

Where do 2/3 of ductal adenocarcinomas of the pancreas tend to be located?

<p>Head of the pancreas (C)</p> Signup and view all the answers

Which of the following is a hormone-secreting non-endocrine neoplasm of the pancreas?

<p>Insulinoma (C)</p> Signup and view all the answers

What is a common diagnostic tool used to confirm obstructive jaundice in patients with pancreatic tumors?

<p>Liver function tests (C)</p> Signup and view all the answers

What is a potential consequence of late-stage diagnosis in over 90% of pancreatic cancer patients?

<p>No chance of cure (B)</p> Signup and view all the answers

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