Endocrine Neoplasms 1 Overview
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Questions and Answers

Which symptom is NOT commonly associated with Medullary thyroid carcinoma in patients with MEN Type 2A?

  • Diarrhea
  • Episodic sweating
  • Hypertension
  • Memory problems (correct)
  • What is a common clinical manifestation of hypercalcemia due to Hyperparathyroidism in MEN Type 2A patients?

  • Nephrolithiasis
  • Constipation (correct)
  • Depression
  • Polyuria
  • Which of the following is a characteristic presentation of cutaneous lichen amyloidosis in multiple endocrine neoplasia type 2A?

  • Multiple pruritic, hyperpigmented, lichenoid papules in the neck
  • Multiple pruritic, hyperpigmented, lichenoid papules in the scapular area of the back (correct)
  • Multiple pruritic, hyperpigmented, lichenoid papules in the limbs
  • Multiple pruritic, hyperpigmented, lichenoid papules in the abdomen
  • What is a characteristic feature of neuromas in patients with MEN Type 2B?

    <p>Bumps around the lips, tongue, and mouth</p> Signup and view all the answers

    How is screening for pheochromocytoma typically conducted in patients suspected of having multiple endocrine neoplasia type 2?

    <p>24-hour urine test for elevated catecholamines and catecholamine metabolites</p> Signup and view all the answers

    In multiple endocrine neoplasia type 2, what does an abdominal MRI scan help to confirm?

    <p>Medullary thyroid carcinoma confirmation</p> Signup and view all the answers

    What gene mutation is responsible for type 1 Multiple Endocrine Neoplasia?

    <p>MENIN</p> Signup and view all the answers

    Which protein, produced by the MENIN gene, acts as a tumor suppressor?

    <p>Menin</p> Signup and view all the answers

    What is the most common initial clinical manifestation of type 1 Multiple Endocrine Neoplasia?

    <p>Hyperparathyroidism</p> Signup and view all the answers

    Which gene mutation is responsible for type 2 Multiple Endocrine Neoplasia?

    <p>RET</p> Signup and view all the answers

    What is the location of the RET gene, responsible for type 2 Multiple Endocrine Neoplasia?

    <p>Chromosome 10q11.2</p> Signup and view all the answers

    What kind of cells does RET lead to hyperplasia in, in type 2 Multiple Endocrine Neoplasia?

    <p>Target cells</p> Signup and view all the answers

    What is the peak incidence age range for non-endocrine malignant tumors of the pancreas?

    <p>50-60 years old</p> Signup and view all the answers

    Which of the following symptoms is NOT typically associated with malignant pancreatic tumors?

    <p>Chest pain</p> Signup and view all the answers

    Where do 2/3 of ductal adenocarcinomas of the pancreas tend to be located?

    <p>Head of the pancreas</p> Signup and view all the answers

    Which of the following is a hormone-secreting non-endocrine neoplasm of the pancreas?

    <p>Insulinoma</p> Signup and view all the answers

    What is a common diagnostic tool used to confirm obstructive jaundice in patients with pancreatic tumors?

    <p>Liver function tests</p> Signup and view all the answers

    What is a potential consequence of late-stage diagnosis in over 90% of pancreatic cancer patients?

    <p>No chance of cure</p> Signup and view all the answers

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