Endo Test 3: Pharmacology - Diabetes

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Questions and Answers

What is the first-line treatment usually recommended for newly diagnosed Type 2 Diabetes Mellitus (T2DM)?

  • Oral drugs
  • Lifestyle modifications (correct)
  • Insulin therapy
  • Weight management

Which of the following is a potential adverse effect of insulin therapy in Type 1 diabetes?

  • Hyperglycemia
  • Weight loss
  • Improved lipid profile
  • Hypoglycemia (correct)

What is the primary role of metformin in decreasing blood glucose levels?

  • Enhancing glycogen breakdown
  • Limiting gluconeogenesis (correct)
  • Stimulating glucagon release
  • Increasing insulin production

Which of the following is NOT a common adverse effect of Metformin?

<p>Migraine headache (A)</p> Signup and view all the answers

What is the primary mechanism of action of Sulfonylureas in the treatment of diabetes?

<p>Binding to sulfonylurea receptor on pancreatic beta-cells (D)</p> Signup and view all the answers

How does Metformin improve insulin sensitivity?

<p>By activating AMPK and increasing peripheral glucose uptake (D)</p> Signup and view all the answers

Which class of drugs inhibits the activity of KATP channels?

<p>Sulfonylureas (A)</p> Signup and view all the answers

What is a common adverse effect associated with sulfonylureas?

<p>Hypoglycemia (C)</p> Signup and view all the answers

Which of the following is NOT a characteristic of meglitinides?

<p>They are largely protein-bound (D)</p> Signup and view all the answers

What is a significant adverse effect that a significant number of patients using sulfonylureas may experience?

<p>Secondary failure (B)</p> Signup and view all the answers

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