Embryology L7: Gut Tube and Body Cavities

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Questions and Answers

What do the pleuroperitoneal membranes fuse with during diaphragm development?

  • Pectoral muscles
  • Esophageal muscles
  • Mesentery of the esophagus (correct)
  • Phrenic nerves

From which cervical segments do the muscle cells of the diaphragm originate?

  • C2—C4
  • C4—C6
  • C3—C5 (correct)
  • C1—C3

What is the primary function of the phrenic nerves in relation to the diaphragm?

  • Control digestion
  • Support spinal column stability
  • Provide blood supply
  • Innervate diaphragm for motor and sensory functions (correct)

What is the main consequence of differential growth during the sixth week of embryo development?

<p>The diaphragm moves ventrally and caudally (C)</p> Signup and view all the answers

Which structure is NOT directly involved in the formation of the diaphragm?

<p>Pulmonary arteries (C)</p> Signup and view all the answers

What is the primary origin of the septum transversum?

<p>Visceral mesoderm (D)</p> Signup and view all the answers

What do the pericardioperitoneal canals become as lung buds grow?

<p>Pleural cavities (A)</p> Signup and view all the answers

Which structures fuse to form the fibrous pericardium in adults?

<p>Pleuropericardial membranes (D)</p> Signup and view all the answers

How does the thoracic cavity divide into definitive compartments?

<p>Via the separation of pleural and pericardial cavities (D)</p> Signup and view all the answers

What is the role of the pleuroperitoneal folds during development?

<p>To close the pericardioperitoneal canals (A)</p> Signup and view all the answers

What tissue gives rise to the definitive wall of the thorax?

<p>Somatic mesoderm (A)</p> Signup and view all the answers

What embryological change causes the enlargement of the pleuropericardial folds?

<p>Lung expansion (A)</p> Signup and view all the answers

What do the pleuropericardial membranes contain?

<p>Phrenic nerves and common cardinal veins (D)</p> Signup and view all the answers

What does the ectoderm layer form during the third and fourth weeks of embryonic development?

<p>Neural tube (A)</p> Signup and view all the answers

Which layer of the embryonic disc is primarily responsible for forming the gut tube?

<p>Endoderm (C)</p> Signup and view all the answers

What is the term for the space between the visceral and parietal layers of lateral plate mesoderm?

<p>Primitive body cavity (C)</p> Signup and view all the answers

At the end of the third week of embryonic development, what does the lateral plate mesoderm differentiate into?

<p>Paraxial, intermediate, and lateral plate mesoderm (A)</p> Signup and view all the answers

Which structure forms the somatopleure?

<p>Parietal layer of mesoderm and overlying ectoderm (C)</p> Signup and view all the answers

What occurs to the lateral plate mesoderm during the formation of the body cavity?

<p>Clefts appear and coalesce, splitting it into two layers (C)</p> Signup and view all the answers

Which layer is intimately connected to the gut tube?

<p>Visceral mesoderm (A)</p> Signup and view all the answers

What is the role of the intermediate mesoderm during embryonic development?

<p>Contribution to the urogenital system (B)</p> Signup and view all the answers

What structures begin to form the lateral body wall folds in the embryo during the fourth week?

<p>Parietal layer of lateral plate mesoderm (B)</p> Signup and view all the answers

Which region does not undergo closure of the ventral body wall?

<p>Connecting stalk (C)</p> Signup and view all the answers

What structure is formed from the endoderm layer folding ventrally during the fourth week?

<p>Gut tube (D)</p> Signup and view all the answers

What happens to the Vitelline duct between the second and third months of gestation?

<p>It degenerates with the yolk sac (A)</p> Signup and view all the answers

What do the cells of the parietal layer of lateral plate mesoderm develop into?

<p>Mesothelial cells forming parietal serous membranes (A)</p> Signup and view all the answers

Where is the dorsal mesentery located in relation to the gut tube?

<p>Extends from the foregut to the hindgut (C)</p> Signup and view all the answers

What is the role of the ventral mesentery?

<p>To provide structural support for the diaphragm (D)</p> Signup and view all the answers

Which of the following statements about visceral and parietal layers of mesoderm is NOT true?

<p>Parietal layers are only found on the exterior of the body cavity. (D)</p> Signup and view all the answers

Flashcards

Pleuroperitoneal membranes

A pair of thin membranes that develop from the folds in the embryo's body wall; these membranes grow inward and fuse with the mesentery of the esophagus, forming the crucial structures of the diaphragm.

Central tendon of the diaphragm

The central, tendon-like part of the diaphragm; it's formed by the fusion of the pleuroperitoneal membranes.

Crura of the diaphragm

The two muscular pillars that extend from the diaphragm to the lumbar vertebrae; they contribute to the diaphragm's shape and function.

Where do diaphragm muscle cells originate?

The development of the diaphragm begins from cervical segments 3-5 (C3-C5), where the initial muscle cells originate.

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Phrenic nerves

These nerves, derived from the cervical spinal cord (C3-C5), control the diaphragm's movement and sensation.

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Neurulation

The process by which the neural plate folds into a tube to form the brain and spinal cord.

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Gut tube

A tube-like structure formed from the endoderm during embryonic development, giving rise to the digestive system.

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Mesoderm

The middle layer of the trilaminar embryonic disc, which forms the muscles, bones, and circulatory system.

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Ectoderm

The outer layer of the trilaminar embryonic disc, which forms the skin, nervous system, and sensory organs.

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Endoderm

The inner layer of the trilaminar embryonic disc, which forms the lining of the digestive and respiratory systems.

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Primitive body cavity

The space between the visceral and parietal layers of lateral plate mesoderm, which eventually becomes the body cavities.

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Parietal (somatic) layer

The layer of mesoderm adjacent to the surface ectoderm, contributes to the formation of the body wall.

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Visceral (splanchnic) layer

The layer of mesoderm adjacent to the endoderm, forms a covering around the gut tube.

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Septum transversum

A thick plate of mesodermal tissue that separates the thoracic cavity from the yolk sac.

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Pericardioperitoneal canals

Openings on each side of the foregut that connect the thoracic and abdominal cavities.

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Pleuropericardial membranes

Extensions of the pleuropericardial folds containing common cardinal veins and phrenic nerves.

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Pleuropericardial membrane fusion

The process of the pleuropericardial membranes fusing with the root of the lungs, separating the thoracic cavity into pericardial and pleural cavities.

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Fibrous pericardium

The fibrous sac that encloses the heart, formed from the pleuropericardial membranes.

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Pleuroperitoneal folds

Crescent-shaped folds that project into the pericardioperitoneal canals, partially closing the opening.

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Pleuroperitoneal fold closure

The process of the pleuroperitoneal folds closing the opening between the pleural and peritoneal cavities.

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Diaphragm

The dome-shaped muscle that separates the thoracic and abdominal cavities.

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Ventral Body Wall Closure

The process of the embryo's sides growing ventrally, forming folds that eventually fuse to create a closed ventral body wall.

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Components of Lateral Body Wall Folds

The folds in the embryo's sides consist of parietal mesoderm, overlying ectoderm, and migrating cells from somites.

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Gut Tube Formation

The endoderm layer folds ventrally and closes, creating the gut tube which will become the digestive system.

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Incomplete Ventral Body Wall Closure

The closure of the ventral body wall is complete except at the site of the future umbilical cord.

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Vitelline Duct

The gut tube also remains incompletely closed, with a connection to the yolk sac called the vitelline (yolk sac) duct.

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Parietal Layer of Serous Membranes

The parietal layer of lateral plate mesoderm lining the embryonic cavity gives rise to the parietal layer of the serous membranes.

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Visceral Layer of Serous Membranes

The visceral layer of lateral plate mesoderm forms the visceral layer of the serous membranes covering the organs.

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Dorsal Mesentery

The dorsal mesentery suspends the gut tube from the posterior body wall into the peritoneal cavity. It's a double layer of peritoneum providing pathways for blood vessels, nerves, and lymphatics.

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Study Notes

Embryology L7: The Gut Tube and Body Cavities

  • The gut tube forms during the third and fourth weeks of development.
  • The neural tube forms simultaneously, creating a tube-on-a-tube structure for the embryo.
  • The mesoderm layer holds the neural tube and gut tube together with its visceral (splanchnic) and parietal (somatic) components.
  • The visceral layer is connected to the gut tube.
  • The parietal layer forms the lateral body wall folds.
  • The space between the visceral and parietal layers is the primitive body cavity, which is initially continuous.
  • The primitive body cavity eventually develops into the pericardial, pleural, and abdomino-pelvic regions.

Formation of the Body Cavity

  • At the end of the third week, intraembryonic mesoderm differentiates into paraxial, intermediate, and lateral plate mesoderm.
  • Paraxial mesoderm forms somitomeres and somites crucial for the skull and vertebrae.
  • Intermediate mesoderm contributes to the urogenital system.
  • Lateral plate mesoderm forms the body cavity.
  • Initially, the lateral plate mesoderm is a solid sheet that splits into two layers; parietal and visceral.
  • The parietal layer, adjacent to the surface ectoderm, is continuous with the extraembryonic parietal layer.
  • The visceral layer is adjacent to the endoderm forming the gut tube.
  • Together, the parietal and visceral layers form the somatopleure and splanchnopleure, respectively.

Serous Membranes

  • Some parietal layer cells form the parietal layer of the serous membranes (peritoneal, pleural, pericardial).
  • Visceral layer cells form the visceral layer of the serous membranes.
  • Visceral and parietal layers connect as the dorsal mesentery, suspending the gut tube from the posterior body wall.
  • The dorsal mesentery extends continuously from the foregut to the hindgut.
  • The ventral mesentery connects the caudal foregut to the duodenum.
  • It results from the thinning of the mesoderm of the septum transversum, a structure important for liver and diaphragm formation.

Diaphragm and Thoracic Cavity

  • The septum transversum is a mesodermal plate between the thoracic and abdominal cavities.
  • It is initially continuous with the visceral mesoderm surrounding the heart.
  • As the lungs expand, the pericardioperitoneal canals become smaller.
  • Pleuropericardial folds grow, fusing with each other and forming the pleuroperitoneal membranes.
  • Mesodermal folds migrate to fuse, forming the pleuroperitoneal membranes and fully closing the thoracic cavity.
  • The pleuropericardial membranes create the fibrous pericardium in the adult.

Formation of the Diaphragm

  • The diaphragm forms from pleuroperitoneal membranes, the muscular components from cervical segments three to five, and the mesentery of the esophagus.
  • Phrenic nerves innervate the diaphragm, originating in the ventral primary rami of C3 to C5.
  • The cervical origin is due to early development of the diaphragm in the fourth week.
  • The diaphragm's descent and final location occur due to differential growth in the embryo.

Clinical Correlates: Ventral Body Wall Defects

  • Defects in the ventral body wall can lead to the protrusion of abdominal organs outside the body, such as hernias.

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