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Questions and Answers
What is the first functional organ to develop in the embryo?
What is the first functional organ to develop in the embryo?
At what day is the heart primordium first evident?
At what day is the heart primordium first evident?
Which of the following structures is part of the primitive heart tube?
Which of the following structures is part of the primitive heart tube?
What happens during lateral folding in the development of the heart?
What happens during lateral folding in the development of the heart?
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What is the fate of the truncus arteriosus in heart development?
What is the fate of the truncus arteriosus in heart development?
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Which end of the endocardial heart tube is the venous end?
Which end of the endocardial heart tube is the venous end?
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What type of mesoderm is involved in the development of the heart?
What type of mesoderm is involved in the development of the heart?
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During cardiac looping, which structure moves dorsally and to the left?
During cardiac looping, which structure moves dorsally and to the left?
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What structure does the sinus venosus open into?
What structure does the sinus venosus open into?
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What happens to the left horn of the sinus venosus during development?
What happens to the left horn of the sinus venosus during development?
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Which vessel is directly connected to the right horn of the sinus venosus?
Which vessel is directly connected to the right horn of the sinus venosus?
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Which part forms the valve of the inferior vena cava?
Which part forms the valve of the inferior vena cava?
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What occurs to the body of the sinus venosus during heart development?
What occurs to the body of the sinus venosus during heart development?
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What structure is associated with the left common cardinal vein?
What structure is associated with the left common cardinal vein?
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Which event is part of the development stages of the atria?
Which event is part of the development stages of the atria?
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Which structures contribute to the septum spurium during development?
Which structures contribute to the septum spurium during development?
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What does the right atrium primarily develop from?
What does the right atrium primarily develop from?
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What structure does the left sinus horn become during development?
What structure does the left sinus horn become during development?
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What is the function of the septum primum during the development of the heart?
What is the function of the septum primum during the development of the heart?
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What is formed when the upper part of septum primum shows gradual resorption?
What is formed when the upper part of septum primum shows gradual resorption?
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Which structure is responsible for dividing the primitive atrium into right and left chambers?
Which structure is responsible for dividing the primitive atrium into right and left chambers?
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What happens to the bulbus cordis during the development of the ventricles?
What happens to the bulbus cordis during the development of the ventricles?
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During the formation of the cardiac septa, what results from the fusion of the endocardial cushions?
During the formation of the cardiac septa, what results from the fusion of the endocardial cushions?
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How many pulmonary veins does the left atrium receive blood from upon completion of its growth?
How many pulmonary veins does the left atrium receive blood from upon completion of its growth?
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What is one of the four heart malformations included in Tetralogy of Fallot?
What is one of the four heart malformations included in Tetralogy of Fallot?
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What happens to the aorta in pulmonary stenosis?
What happens to the aorta in pulmonary stenosis?
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Which structure is formed by the division of the truncus arteriosus?
Which structure is formed by the division of the truncus arteriosus?
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What characterizes Transposition of the Great Arteries (TGA)?
What characterizes Transposition of the Great Arteries (TGA)?
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Which fetal structure carries oxygenated blood from the placenta to the fetal circulation?
Which fetal structure carries oxygenated blood from the placenta to the fetal circulation?
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Which aortic arch forms the common carotids and the first part of the internal carotids?
Which aortic arch forms the common carotids and the first part of the internal carotids?
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In fetal circulation, where does the oxygenated blood mix with deoxygenated blood?
In fetal circulation, where does the oxygenated blood mix with deoxygenated blood?
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Which arch does not form in humans?
Which arch does not form in humans?
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What primarily contributes to the formation of the left ventricle?
What primarily contributes to the formation of the left ventricle?
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What is the primary interventricular foramen formed by?
What is the primary interventricular foramen formed by?
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Which structure aids in the partition of the truncus arteriosus?
Which structure aids in the partition of the truncus arteriosus?
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Which type of atrial septal defect results in a common atrium?
Which type of atrial septal defect results in a common atrium?
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What primarily constitutes the right ventricle?
What primarily constitutes the right ventricle?
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What remains open in Roger’s disease?
What remains open in Roger’s disease?
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What is the role of the conus arteriosus?
What is the role of the conus arteriosus?
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What occurs during the first step of ventricular septum formation?
What occurs during the first step of ventricular septum formation?
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What is the purpose of the ductus venosus in fetal circulation?
What is the purpose of the ductus venosus in fetal circulation?
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How does blood flow from the right atrium to the left atrium in fetal circulation?
How does blood flow from the right atrium to the left atrium in fetal circulation?
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What physiological change triggers the closure of the ductus arteriosus after birth?
What physiological change triggers the closure of the ductus arteriosus after birth?
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What structure does the ductus arteriosus become after closure?
What structure does the ductus arteriosus become after closure?
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What happens to blood flow to the left atrium after the ductus arteriosus closes?
What happens to blood flow to the left atrium after the ductus arteriosus closes?
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What occurs to the foramen ovale after birth?
What occurs to the foramen ovale after birth?
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What structural change occurs to the ductus venosus after the umbilical cord is cut?
What structural change occurs to the ductus venosus after the umbilical cord is cut?
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Why is it important for the fetal heart to bypass pulmonary circulation?
Why is it important for the fetal heart to bypass pulmonary circulation?
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Flashcards
Cardiogenic fields
Cardiogenic fields
The initial stage of heart development, where two tubes form from the mesoderm layer of the embryo.
Endocardial heart tubes
Endocardial heart tubes
The two tubes formed from the cardiogenic fields that fuse together to create the single heart tube.
Lateral folding
Lateral folding
The process of the embryo folding in on itself, bringing the cardiogenic fields to the midline to form the heart tube.
Cephalocaudal Folding
Cephalocaudal Folding
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Heart
Heart
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Cardiac Looping
Cardiac Looping
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Pericardial sac
Pericardial sac
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Septum formation
Septum formation
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Right Atrium Development
Right Atrium Development
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Left Atrium Development
Left Atrium Development
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Atrioventricular Canal Formation
Atrioventricular Canal Formation
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Septum Primum Formation
Septum Primum Formation
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Ostium Secundum Formation
Ostium Secundum Formation
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Septum Secundum and Foramen Ovale Formation
Septum Secundum and Foramen Ovale Formation
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Bulbus Cordis Movement
Bulbus Cordis Movement
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Heart Development Timeline
Heart Development Timeline
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What is the sinus venosus?
What is the sinus venosus?
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What happens to the horns of the sinus venosus during development?
What happens to the horns of the sinus venosus during development?
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What is the septum spurium and how does it form?
What is the septum spurium and how does it form?
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What happens to the body and right horn of the sinus venosus?
What happens to the body and right horn of the sinus venosus?
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What does the left horn of the sinus venosus become?
What does the left horn of the sinus venosus become?
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What are the derivatives of the right valve of the sinus venosus?
What are the derivatives of the right valve of the sinus venosus?
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What is the role of the endocardial cushions in atrial development?
What is the role of the endocardial cushions in atrial development?
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What is the interatrial septum and what role does it play?
What is the interatrial septum and what role does it play?
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Ventricular Septation
Ventricular Septation
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Primary Interventricular Foramen
Primary Interventricular Foramen
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Membranous Interventricular Septum
Membranous Interventricular Septum
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What does the bulbus cordis form?
What does the bulbus cordis form?
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Conus Arteriosus
Conus Arteriosus
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Aortic Vestibule
Aortic Vestibule
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Partition of Truncus Arteriosus
Partition of Truncus Arteriosus
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Aorticopulmonary Septum
Aorticopulmonary Septum
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Ductus venosus
Ductus venosus
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Foramen ovale
Foramen ovale
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Ductus arteriosus
Ductus arteriosus
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Closure of the ductus arteriosus
Closure of the ductus arteriosus
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Closure of the foramen ovale
Closure of the foramen ovale
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Closure of the ductus venosus
Closure of the ductus venosus
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Fetal to neonatal circulation transition
Fetal to neonatal circulation transition
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Changes to the circulation after birth
Changes to the circulation after birth
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Tetralogy of Fallot
Tetralogy of Fallot
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Transposition of Great Arteries (TGA)
Transposition of Great Arteries (TGA)
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Truncus Arteriosus Division
Truncus Arteriosus Division
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Sixth Aortic Arch Development
Sixth Aortic Arch Development
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Fourth Aortic Arch Development
Fourth Aortic Arch Development
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Third Aortic Arch Development
Third Aortic Arch Development
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Fetal Blood Flow - Oxygenated Blood
Fetal Blood Flow - Oxygenated Blood
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Fetal Circulation Differences
Fetal Circulation Differences
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Study Notes
Embryology of the Cardiovascular System
- The cardiovascular system (CVS) develops as two regions near the cranial end of the embryo, derived from mesoderm.
- The heart primordium is evident at 18 days, forming angioplastic cords which develop into heart tubes.
- The heart is the first functional organ to develop.
- It develops from splanchnic mesoderm in the wall of the yolk sac.
- Angiogenic cells form right and left endocardial heart tubes.
- Embryonic folding, involving lateral and cephalocaudal folding, brings the cardiogenic fields to the midline, allowing the primitive heart tube to form.
Primitive Heart Tube
- Composed of five distinct segments:
- Sinus venosus
- Truncus arteriosus
- Bulbus cordis
- Common ventricle
- Common atrium
- The endocardial heart tube has a venous end (sinus venosus) and an arterial end (truncus arteriosus).
Cardiac Looping
- The heart tube grows and elongates, requiring looping to fit within the pericardial sac.
- The primitive ventricle moves ventrally.
- The primitive atrium moves dorsally and to the left.
- This places the inflow portion (veins and atria) behind the outflow portion (ventricles and arteries).
- Fetal hearts exhibit this same configuration.
Fate of the Sinus Venosus
- The body of the sinus venosus is absorbed into the primitive atrium, forming part of the right atrium.
- The septum spurium (a partition) and left venous valves combine with the inter-atrial septum.
- The right horn of the sinus venosus contributes to the superior vena cava and valve of the coronary sinus.
- The left horn contributes to the coronary sinus.
- The common cardinal veins may develop into the oblique vein of the left atrium (vein of Marshall) or the inferior portion of the superior vena cava on the right side.
- The umbilical and vitelline veins in the left horn typically lose connection in later development.
Development of the Atria
- The atrioventricular canal divides into two halves due to the development of a ventral and dorsal endocardial cushion.
- Subsequent division of the primitive common atrium results in right and left atria.
- The right horn of the sinus venosus is absorbed by the right atrium.
- Pulmonary veins are absorbed into the left atrium.
Development of the Ventricles
- The bulbus cordis is on the right initially but shifts ventral to the ventricle.
- The separate bulboventricular sulcus disappears, forming a common chamber.
- The interventricular septum develops, dividing the common chamber into the right and left ventricles.
- The right ventricle develops mainly from the bulbus cordis while the left ventricle develops partly from the bulbus cordis and partly from the primitive ventricle.
Partition of the Truncus Arteriosus
- The bulbus cordis and truncus arteriosus initially form a single tube, but an aorticopulmonary septum divides it into the aorta and pulmonary trunk in the 5th week.
- This septum develops from endocardial cushions.
- The septum divides the truncus arteriosus into right and left portions (for pulmonary trunk and aorta).
- Septum divides the truncus arteriosus into distinct regions: lower, middle, and upper.
Major Cardiac Anomalies
- Atrial Septal Defects (ASD): Absence of the septum primum and/or septum secundum leading to a common atrium.
- Ventricular Septal Defect (VSD): Absence of the membranous part of the interventricular septum.
- Tetralogy of Fallot: A combination of four congenital heart defects: VSD, pulmonary stenosis, overriding aorta, and right ventricular hypertrophy.
- Transposition of the Great Arteries (TGA): Abnormal rotation of aorticopulmonary septum causing the right ventricle to connect to the aorta and the left ventricle to the pulmonary artery.
Fetal Circulation
- Oxygenated blood from the placenta enters the fetus via the umbilical vein.
- This blood bypasses the liver via the ductus venosus.
- Most blood enters the left atrium via the foramen ovale, bypassing the pulmonary circuit.
- Blood flows to the systemic circulation from the left ventricle via the aorta.
- Blood in the pulmonary trunk from the right ventricle is shunted into the systemic circulation via the ductus arteriosus.
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Test your knowledge on the development of the heart during embryology. This quiz covers key stages, structures, and processes involved in heart formation from the embryo's earliest stages. Whether you're a student or an enthusiast, challenge yourself with these insightful questions!