Embryology Heart Development Quiz
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Questions and Answers

What is the first functional organ to develop in the embryo?

  • Heart (correct)
  • Kidneys
  • Lungs
  • Liver
  • At what day is the heart primordium first evident?

  • 14 days
  • 18 days (correct)
  • 25 days
  • 21 days
  • Which of the following structures is part of the primitive heart tube?

  • Right Atrium
  • Aortic Arch
  • Pulmonary Vein
  • Bulbus Cordis (correct)
  • What happens during lateral folding in the development of the heart?

    <p>Cardiogenic fields merge into the midline (B)</p> Signup and view all the answers

    What is the fate of the truncus arteriosus in heart development?

    <p>Forms the pulmonary trunk and aorta (A)</p> Signup and view all the answers

    Which end of the endocardial heart tube is the venous end?

    <p>Sinus Venosus (C)</p> Signup and view all the answers

    What type of mesoderm is involved in the development of the heart?

    <p>Splanchnic mesoderm (B)</p> Signup and view all the answers

    During cardiac looping, which structure moves dorsally and to the left?

    <p>Primitive Atrium (A)</p> Signup and view all the answers

    What structure does the sinus venosus open into?

    <p>Primitive atrium (D)</p> Signup and view all the answers

    What happens to the left horn of the sinus venosus during development?

    <p>It forms the coronary sinus (C)</p> Signup and view all the answers

    Which vessel is directly connected to the right horn of the sinus venosus?

    <p>Common cardinal vein (C)</p> Signup and view all the answers

    Which part forms the valve of the inferior vena cava?

    <p>Caudal part of the right valve (A)</p> Signup and view all the answers

    What occurs to the body of the sinus venosus during heart development?

    <p>It becomes absorbed into the primitive atrium (A)</p> Signup and view all the answers

    What structure is associated with the left common cardinal vein?

    <p>Vein of Marshall (B)</p> Signup and view all the answers

    Which event is part of the development stages of the atria?

    <p>Absorption of the pulmonary veins into the left atrium (D)</p> Signup and view all the answers

    Which structures contribute to the septum spurium during development?

    <p>Right venous valve and left venous valve (B)</p> Signup and view all the answers

    What does the right atrium primarily develop from?

    <p>Most of the primitive atrium and a part of the sinus venosus (D)</p> Signup and view all the answers

    What structure does the left sinus horn become during development?

    <p>The coronary sinus (D)</p> Signup and view all the answers

    What is the function of the septum primum during the development of the heart?

    <p>To grow toward the septum intermedium and eventually create the foramen secundum (D)</p> Signup and view all the answers

    What is formed when the upper part of septum primum shows gradual resorption?

    <p>The ostium secondum (D)</p> Signup and view all the answers

    Which structure is responsible for dividing the primitive atrium into right and left chambers?

    <p>Inter-atrial septum (C)</p> Signup and view all the answers

    What happens to the bulbus cordis during the development of the ventricles?

    <p>It moves slightly ventral to the ventricle (D)</p> Signup and view all the answers

    During the formation of the cardiac septa, what results from the fusion of the endocardial cushions?

    <p>The septum intermedium (D)</p> Signup and view all the answers

    How many pulmonary veins does the left atrium receive blood from upon completion of its growth?

    <p>Four (C)</p> Signup and view all the answers

    What is one of the four heart malformations included in Tetralogy of Fallot?

    <p>Ventricular septal defect (B)</p> Signup and view all the answers

    What happens to the aorta in pulmonary stenosis?

    <p>It becomes larger than the pulmonary artery (D)</p> Signup and view all the answers

    Which structure is formed by the division of the truncus arteriosus?

    <p>Pulmonary trunk and aorta (B)</p> Signup and view all the answers

    What characterizes Transposition of the Great Arteries (TGA)?

    <p>Both ventricles connect to the aorta (C)</p> Signup and view all the answers

    Which fetal structure carries oxygenated blood from the placenta to the fetal circulation?

    <p>Umbilical vein (B)</p> Signup and view all the answers

    Which aortic arch forms the common carotids and the first part of the internal carotids?

    <p>Third arch (C)</p> Signup and view all the answers

    In fetal circulation, where does the oxygenated blood mix with deoxygenated blood?

    <p>In the inferior vena cava (A)</p> Signup and view all the answers

    Which arch does not form in humans?

    <p>Fifth arch (C)</p> Signup and view all the answers

    What primarily contributes to the formation of the left ventricle?

    <p>Mainly from the primitive ventricle with some contribution from bulbus cordis (C)</p> Signup and view all the answers

    What is the primary interventricular foramen formed by?

    <p>The muscular portion grows from the floor of the ventricle (C)</p> Signup and view all the answers

    Which structure aids in the partition of the truncus arteriosus?

    <p>Spiral Septum (aorticopulmonary septum) (C)</p> Signup and view all the answers

    Which type of atrial septal defect results in a common atrium?

    <p>Absence of both septum primum and septum secundum (A)</p> Signup and view all the answers

    What primarily constitutes the right ventricle?

    <p>Mainly from the bulbus cordis with some from the primitive ventricle (A)</p> Signup and view all the answers

    What remains open in Roger’s disease?

    <p>The membranous part of the interventricular septum (D)</p> Signup and view all the answers

    What is the role of the conus arteriosus?

    <p>Connects the right ventricle to the pulmonary trunk (D)</p> Signup and view all the answers

    What occurs during the first step of ventricular septum formation?

    <p>Muscular tissue grows upwards from the ventricle floor (C)</p> Signup and view all the answers

    What is the purpose of the ductus venosus in fetal circulation?

    <p>To bypass the developing liver (C)</p> Signup and view all the answers

    How does blood flow from the right atrium to the left atrium in fetal circulation?

    <p>Through the foramen ovale (D)</p> Signup and view all the answers

    What physiological change triggers the closure of the ductus arteriosus after birth?

    <p>Increase in pO2 levels (D)</p> Signup and view all the answers

    What structure does the ductus arteriosus become after closure?

    <p>Ligamentum arteriosum (C)</p> Signup and view all the answers

    What happens to blood flow to the left atrium after the ductus arteriosus closes?

    <p>It increases due to increased venous return (D)</p> Signup and view all the answers

    What occurs to the foramen ovale after birth?

    <p>It becomes the walled-off fossa ovalis (B)</p> Signup and view all the answers

    What structural change occurs to the ductus venosus after the umbilical cord is cut?

    <p>It transforms into the ligamentum teres (A)</p> Signup and view all the answers

    Why is it important for the fetal heart to bypass pulmonary circulation?

    <p>Fetal blood cannot receive oxygen from the lungs (D)</p> Signup and view all the answers

    Flashcards

    Cardiogenic fields

    The initial stage of heart development, where two tubes form from the mesoderm layer of the embryo.

    Endocardial heart tubes

    The two tubes formed from the cardiogenic fields that fuse together to create the single heart tube.

    Lateral folding

    The process of the embryo folding in on itself, bringing the cardiogenic fields to the midline to form the heart tube.

    Cephalocaudal Folding

    The bending of the embryo's head towards its tail, which brings the cardiogenic fields from the cranial end to the center of the embryo.

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    Heart

    The first functional organ to develop in the embryo. It begins beating between 22 to 23 days after fertilization.

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    Cardiac Looping

    The process by which the heart tube bends and shapes itself, forming the distinct chambers of the heart.

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    Pericardial sac

    The sac surrounding the developing heart tube.

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    Septum formation

    The process of creating the septum (wall) that divides the heart into its four chambers.

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    Right Atrium Development

    The right atrium develops from most of the primitive atrium and a part of the sinus venosus. The sinus venosus receives blood from the right and left sinus horns, bringing blood into the primitive heart tube.

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    Left Atrium Development

    The left atrium develops from a small part of the primitive atrium and the proximal portions of the pulmonary veins. The pulmonary veins begin as one vein entering the left atrium, forming from four branches that converge to form one vein draining into the developing left atrium.

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    Atrioventricular Canal Formation

    The atrioventricular canal, the elongated constriction between the primitive atrium and ventricle, is divided into right and left parts by the septum intermedium formed by the fusion of two endocardial cushions.

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    Septum Primum Formation

    The septum primum, a crescent-shaped membrane growing from the roof, forms a gap between itself and the septum intermedium, the foramen primum. Later, the septum primum ruptures to form the foramen secundum.

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    Ostium Secundum Formation

    The upper part of the septum primum resorbs, leaving an opening called the ostium secundum.

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    Septum Secundum and Foramen Ovale Formation

    The septum secundum forms on the right side of the septum primum, creating a valvular oval foramen - the foramen ovale.

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    Bulbus Cordis Movement

    The bulbus cordis, initially located to the right of the primitive ventricle, moves slightly ventral to the ventricle.

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    Heart Development Timeline

    The first functional organ to develop in the embryo, the heart begins beating between 22 and 23 days after fertilization.

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    What is the sinus venosus?

    The sinus venosus is a structure in the developing heart that receives blood from the yolk sac, placenta, and fetal body.

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    What happens to the horns of the sinus venosus during development?

    During development, the right horn of the sinus venosus enlarges, while the left regresses due to a shifting of blood flow.

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    What is the septum spurium and how does it form?

    The septum spurium, a thin tissue partition, forms from the fusion of venous valves guarding the sinu-atrial orifice.

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    What happens to the body and right horn of the sinus venosus?

    The body and right horn of the sinus venosus are absorbed into the primitive atrium, contributing to the smooth part of the adult right atrium.

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    What does the left horn of the sinus venosus become?

    The left horn of the sinus venosus develops into the coronary sinus, a channel that collects blood from the heart muscle.

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    What are the derivatives of the right valve of the sinus venosus?

    The right valve of the sinus venosus forms part of the crista terminalis and the valves of the inferior vena cava and coronary sinus.

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    What is the role of the endocardial cushions in atrial development?

    The division of the atrioventricular canal into two halves by endocardial cushions is a key step in the development of the atria and ventricles.

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    What is the interatrial septum and what role does it play?

    The interatrial septum, a wall that separates the right and left atria, is formed during atrial development.

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    Ventricular Septation

    The process of forming the septum (wall) that divides the heart into its four chambers.

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    Primary Interventricular Foramen

    A muscular portion of heart tissue grows upwards from the floor of the primitive ventricle towards the endocardial cushions, forming the primary interventricular foramen, the opening between the ventricles.

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    Membranous Interventricular Septum

    A membranous portion grows downwards from the endocardial cushions to meet the membranous part of the muscular portion, closing the primary interventricular foramen. This completes ventricular separation.

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    What does the bulbus cordis form?

    The smooth upper part of the two ventricles. It forms the outflow tracts, the conus arteriosus for the right ventricle and the aortic vestibule for the left ventricle.

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    Conus Arteriosus

    The outflow tract of the right ventricle that leads to the pulmonary trunk.

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    Aortic Vestibule

    The outflow tract of the left ventricle that leads to the ascending aorta.

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    Partition of Truncus Arteriosus

    The truncus arteriosus and bulbus cordis form one tube allowing outflow from the heart. This tube needs to be split to form the aorta and pulmonary trunk.

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    Aorticopulmonary Septum

    Mesenchymal cells proliferate in the wall of the truncus arteriosus forming a spiral septum called the aorticopulmonary septum, dividing the truncus arteriosus and forming the aorta and pulmonary trunk.

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    Ductus venosus

    A shunt that connects the umbilical vein to the inferior vena cava, bypassing the liver in fetal circulation.

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    Foramen ovale

    An opening between the right and left atria that allows blood to bypass the pulmonary circulation in fetal circulation.

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    Ductus arteriosus

    A channel that connects the pulmonary trunk to the aorta, bypassing the pulmonary circulation in fetal circulation.

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    Closure of the ductus arteriosus

    The closure of the ductus arteriosus after birth, triggered by increased oxygen levels.

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    Closure of the foramen ovale

    The closure of the foramen ovale after birth, triggered by increased pressure in the left atrium.

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    Closure of the ductus venosus

    The closure of the ductus venosus after birth, triggered by the cessation of umbilical cord blood flow.

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    Fetal to neonatal circulation transition

    The process by which a fetus adapts to breathing air after birth, transitioning from the placenta to the lungs for oxygen.

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    Changes to the circulation after birth

    The changes in blood flow and heart structures that occur after birth, enabling the baby to breathe independently.

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    Tetralogy of Fallot

    A condition involving four heart defects: a ventricular septal defect (VSD), pulmonary stenosis, right ventricular hypertrophy, and overriding aorta. This leads to a mix of oxygenated and deoxygenated blood, causing cyanosis.

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    Transposition of Great Arteries (TGA)

    A serious heart defect where the aorta and pulmonary artery are connected to the wrong ventricles. The aorta receives blood from the right ventricle (deoxygenated), and the pulmonary artery receives blood from the left ventricle (oxygenated), leading to insufficient oxygenation.

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    Truncus Arteriosus Division

    The division of the truncus arteriosus by the aorticopulmonary septum, forming two major vessels: the aorta and the pulmonary trunk.

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    Sixth Aortic Arch Development

    The sixth aortic arch develops into the pulmonary arteries, connecting to the pulmonary trunk. The left side retains its connection via the ductus arteriosus, while the right side loses it. Closure of the ductus arteriosus separates pulmonary and systemic circulations.

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    Fourth Aortic Arch Development

    The fourth aortic arch becomes the arch of the aorta on the left and the right subclavian artery on the right.

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    Third Aortic Arch Development

    The third aortic arch develops into the common carotid arteries and the initial part of the internal carotid arteries.

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    Fetal Blood Flow - Oxygenated Blood

    Oxygenated blood from the placenta enters the fetal circulation through the umbilical vein, mixes with deoxygenated blood in the inferior vena cava, and is then directed towards the heart.

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    Fetal Circulation Differences

    The fetal circulation is unique, as the fetus receives oxygenated blood from the placenta and not from the lungs. The fetal heart has connections and bypasses that are essential for this unique circulatory system.

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    Study Notes

    Embryology of the Cardiovascular System

    • The cardiovascular system (CVS) develops as two regions near the cranial end of the embryo, derived from mesoderm.
    • The heart primordium is evident at 18 days, forming angioplastic cords which develop into heart tubes.
    • The heart is the first functional organ to develop.
    • It develops from splanchnic mesoderm in the wall of the yolk sac.
    • Angiogenic cells form right and left endocardial heart tubes.
    • Embryonic folding, involving lateral and cephalocaudal folding, brings the cardiogenic fields to the midline, allowing the primitive heart tube to form.

    Primitive Heart Tube

    • Composed of five distinct segments:
      • Sinus venosus
      • Truncus arteriosus
      • Bulbus cordis
      • Common ventricle
      • Common atrium
    • The endocardial heart tube has a venous end (sinus venosus) and an arterial end (truncus arteriosus).

    Cardiac Looping

    • The heart tube grows and elongates, requiring looping to fit within the pericardial sac.
    • The primitive ventricle moves ventrally.
    • The primitive atrium moves dorsally and to the left.
    • This places the inflow portion (veins and atria) behind the outflow portion (ventricles and arteries).
    • Fetal hearts exhibit this same configuration.

    Fate of the Sinus Venosus

    • The body of the sinus venosus is absorbed into the primitive atrium, forming part of the right atrium.
    • The septum spurium (a partition) and left venous valves combine with the inter-atrial septum.
    • The right horn of the sinus venosus contributes to the superior vena cava and valve of the coronary sinus.
    • The left horn contributes to the coronary sinus.
    • The common cardinal veins may develop into the oblique vein of the left atrium (vein of Marshall) or the inferior portion of the superior vena cava on the right side.
    • The umbilical and vitelline veins in the left horn typically lose connection in later development.

    Development of the Atria

    • The atrioventricular canal divides into two halves due to the development of a ventral and dorsal endocardial cushion.
    • Subsequent division of the primitive common atrium results in right and left atria.
    • The right horn of the sinus venosus is absorbed by the right atrium.
    • Pulmonary veins are absorbed into the left atrium.

    Development of the Ventricles

    • The bulbus cordis is on the right initially but shifts ventral to the ventricle.
    • The separate bulboventricular sulcus disappears, forming a common chamber.
    • The interventricular septum develops, dividing the common chamber into the right and left ventricles.
    • The right ventricle develops mainly from the bulbus cordis while the left ventricle develops partly from the bulbus cordis and partly from the primitive ventricle.

    Partition of the Truncus Arteriosus

    • The bulbus cordis and truncus arteriosus initially form a single tube, but an aorticopulmonary septum divides it into the aorta and pulmonary trunk in the 5th week.
    • This septum develops from endocardial cushions.
    • The septum divides the truncus arteriosus into right and left portions (for pulmonary trunk and aorta).
    • Septum divides the truncus arteriosus into distinct regions: lower, middle, and upper.

    Major Cardiac Anomalies

    • Atrial Septal Defects (ASD): Absence of the septum primum and/or septum secundum leading to a common atrium.
    • Ventricular Septal Defect (VSD): Absence of the membranous part of the interventricular septum.
    • Tetralogy of Fallot: A combination of four congenital heart defects: VSD, pulmonary stenosis, overriding aorta, and right ventricular hypertrophy.
    • Transposition of the Great Arteries (TGA): Abnormal rotation of aorticopulmonary septum causing the right ventricle to connect to the aorta and the left ventricle to the pulmonary artery.

    Fetal Circulation

    • Oxygenated blood from the placenta enters the fetus via the umbilical vein.
    • This blood bypasses the liver via the ductus venosus.
    • Most blood enters the left atrium via the foramen ovale, bypassing the pulmonary circuit.
    • Blood flows to the systemic circulation from the left ventricle via the aorta.
    • Blood in the pulmonary trunk from the right ventricle is shunted into the systemic circulation via the ductus arteriosus.

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    Test your knowledge on the development of the heart during embryology. This quiz covers key stages, structures, and processes involved in heart formation from the embryo's earliest stages. Whether you're a student or an enthusiast, challenge yourself with these insightful questions!

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