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Questions and Answers
Which complex is responsible for pumping 4 H+ from the matrix to the intermembrane space during electron transport?
Which complex is responsible for pumping 4 H+ from the matrix to the intermembrane space during electron transport?
- Complex II (Succinate dehydrogenase)
- Complex I (NADH dehydrogenase) (correct)
- Complex IV (cytochrome oxidase)
- Complex III (cytochrome oxidase)
Which complex is the only electron carrier that has a site available for reacting directly with O2 and contains the copper required to reduce O2 to water?
Which complex is the only electron carrier that has a site available for reacting directly with O2 and contains the copper required to reduce O2 to water?
- Complex III (cytochrome oxidase)
- Complex I (NADH dehydrogenase)
- Complex II (Succinate dehydrogenase)
- Complex IV (cytochrome oxidase) (correct)
Which compound has a large negative standard reduction potential (E0) and acts as an oxidizing agent?
Which compound has a large negative standard reduction potential (E0) and acts as an oxidizing agent?
- FMNH2
- NAD+ (correct)
- FMN
- NADH
Which complex catalyzes the oxidation of succinate to fumarate?
Which complex catalyzes the oxidation of succinate to fumarate?
Which complex is responsible for pumping 4 H+ during electron transport?
Which complex is responsible for pumping 4 H+ during electron transport?
Which compound binds to the reduced Fe2+ of cytochrome oxidase and inhibits electron transport in Complex IV?
Which compound binds to the reduced Fe2+ of cytochrome oxidase and inhibits electron transport in Complex IV?
Which complex is inhibited by rotenone, preventing electron transfer between FMN and CoQ?
Which complex is inhibited by rotenone, preventing electron transfer between FMN and CoQ?
Which compound binds to heme iron (Fe3+) in cyto a+a3 and prevents the reduction of electrons in Complex IV?
Which compound binds to heme iron (Fe3+) in cyto a+a3 and prevents the reduction of electrons in Complex IV?
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Study Notes
Electron Transport Complexes
- Complex I (NADH dehydrogenase) is responsible for pumping 4 H+ from the matrix to the intermembrane space during electron transport.
- Complex IV (cytochrome c oxidase) is the only electron carrier that has a site available for reacting directly with O2 and contains the copper required to reduce O2 to water.
Electron Carriers and Inhibitors
- Coenzyme Q (CoQ) has a large negative standard reduction potential (E0) and acts as an oxidizing agent.
- Succinate dehydrogenase (Complex II) catalyzes the oxidation of succinate to fumarate.
Inhibitors of Electron Transport
- Antimycin A binds to the reduced Fe2+ of cytochrome oxidase and inhibits electron transport in Complex IV.
- Rotenone inhibits Complex I, preventing electron transfer between FMN and CoQ.
- Cyanide binds to heme iron (Fe3+) in cytochrome a+a3 and prevents the reduction of electrons in Complex IV.
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