30 Questions
What is the alternative pathway of converting DAG to arachidonic acid?
DAG is converted to MAG by DAG lipase and then broken down to arachidonic acid
What is the characteristic of eicosanoids that makes them susceptible to oxidation?
Presence of double bonds
Which enzyme converts arachidonic acid to prostaglandins?
COX
What is the result of TXA2 action in platelets?
Pro-coagulation
What is the effect of PGE2 on the body?
Promoting fever, pain
What is the target of NSAID?
COX
What is the effect of PGE compounds on the release of NE from sympathetic presynaptic nerve endings?
They inhibit the release
Which of the following neurohormones is NOT promoted by PG compounds?
Insulin
What is the enzyme responsible for converting Leukotriene A4 to Leukotriene B4?
LTA4 hydrolase
In the airway, what is the effect of LTC4, LTD4, and LTE4?
They are powerful bronchoconstrictors
What is the role of LTB4 in the GIT?
It is a chemoattractant for neutrophils
What is the effect of LTC4 or LTD4 on myocardial contractility and coronary blood flow?
They decrease myocardial contractility and coronary blood flow
What is the main function of COX-1?
To maintain a protective barrier in the stomach against gastric acid
Which of the following NSAIDs is selective for COX-2?
Celecoxib
What is the effect of inhibiting COX-1 on mucus secretion in the stomach?
It decreases mucus secretion
What is the role of Gs protein receptor in the prostaglandin pathway?
It activates adenylyl cyclase
What is the effect of increased cAMP levels on Protein Kinase A?
It activates Protein Kinase A
What is the difference between COX-1 and COX-2?
COX-1 is constitutive, while COX-2 is inducible
What is the primary mechanism of pain relief for paracetamol?
Affecting a different mechanism that does not involve inflammation
What is the primary effect of low doses of aspirin on the body?
Antithrombotic effect
What is the primary bronchodilator in the eicosanoid pathway?
PGE2
What is the main mediator of asthma in the eicosanoid pathway?
Leukotrienes C4, D4, and E4
What is the effect of PGE1, PGE2, and PGI2 on the glomerular filtration rate?
Increase the glomerular filtration rate
What is the secondary effect of PGE1, PGE2, and PGI2 on the renal system?
Increase water and Na+ excretion
What is the primary use of dinoprostone?
Inducing labor
Which prostaglandin is used to treat impotence?
Alprostadil
What is the mechanism of action of prostacyclin?
It is a vasodilator and inhibitor of platelet aggregation
What is the use of misoprostol in combination with mifepristone?
To terminate early pregnancies
Which prostaglandin is used to maintain ductus arteriosus patent in neonates?
Alprostadil
What is the function of 10, 16, dimethyl PGE4?
It is a cytoprotective agent against gastric ulcer
This quiz covers the conversion of diacylglycerol (DAG) to monoacylglycerol (MAG) and eventually to arachidonic acid, as well as the different types of eicosanoids such as arachidonic acid, eicosatrienoic acid, and eicosapentaenoic acid. It also touches on the role of fish oil in eicosanoid metabolism.
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