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Questions and Answers
What is the main reason why the full therapeutic effect of Prozac may be delayed according to the text?
What is the main reason why the full therapeutic effect of Prozac may be delayed according to the text?
- Synthesis of serotonin receptors
- Interaction with dopamine receptors
- Astrocytes induction of trophic factors (correct)
- Direct modulation of GABAergic neurotransmission
What effect did treating cultured astrocytes with serotonin have on trophic factors synthesis?
What effect did treating cultured astrocytes with serotonin have on trophic factors synthesis?
- Decreased synthesis
- No effect on synthesis (correct)
- Induced apoptosis
- Increased synthesis
Based on the information provided, what is the potential role of astrocytes in the therapeutic effects of Prozac?
Based on the information provided, what is the potential role of astrocytes in the therapeutic effects of Prozac?
- Induction of GABAergic receptors
- Synthesis of neurotrophic growth factors (correct)
- Direct modulation of neurotransmitter reuptake
- Increased release of serotonin
What does the evidence suggest in relation to the presence of depressive symptoms in humans and animal models?
What does the evidence suggest in relation to the presence of depressive symptoms in humans and animal models?
How does the text explain the delayed therapeutic effect of Prozac when considering its action on astrocytes?
How does the text explain the delayed therapeutic effect of Prozac when considering its action on astrocytes?
What is the effect of serotonin treatment on the synthesis of neurotrophic growth factors in cultured astrocytes?
What is the effect of serotonin treatment on the synthesis of neurotrophic growth factors in cultured astrocytes?
What is the supposed mechanism of action of Prozac in the brain?
What is the supposed mechanism of action of Prozac in the brain?
Which of the following trophic factors is NOT mentioned as being increased in astrocytes treated with Fluoxetine?
Which of the following trophic factors is NOT mentioned as being increased in astrocytes treated with Fluoxetine?
In the study presented, what effect did Prozac have on astrocytes?
In the study presented, what effect did Prozac have on astrocytes?
Which brain regions showed down-regulation of GFAP levels in suicide cases, indicating astrocytic pathology?
Which brain regions showed down-regulation of GFAP levels in suicide cases, indicating astrocytic pathology?
What is the primary role of astrocytes in the brain?
What is the primary role of astrocytes in the brain?
Which of the following is a common therapeutic effect associated with Prozac use?
Which of the following is a common therapeutic effect associated with Prozac use?
What is the consequence of the decreased level of connexin 43 protein in stressed rats?
What is the consequence of the decreased level of connexin 43 protein in stressed rats?
Which neurotransmitter system is likely impacted by Fluoxetine and Duloxetine treatments?
Which neurotransmitter system is likely impacted by Fluoxetine and Duloxetine treatments?
In the context of astrocytes, what impact does the chronic stress have on coupled cells?
In the context of astrocytes, what impact does the chronic stress have on coupled cells?
How does chronic unpredictable stress affect trophic factors synthesis in astrocytes?
How does chronic unpredictable stress affect trophic factors synthesis in astrocytes?
What is the primary therapeutic effect of Fluoxetine (Prozac) observed in the context of connexin 43 levels restoration?
What is the primary therapeutic effect of Fluoxetine (Prozac) observed in the context of connexin 43 levels restoration?
What is the observed impact of antidepressant treatment on the diffusion distance of the dye in the rat brain?
What is the observed impact of antidepressant treatment on the diffusion distance of the dye in the rat brain?
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