18 Questions
What is the main reason why the full therapeutic effect of Prozac may be delayed according to the text?
Astrocytes induction of trophic factors
What effect did treating cultured astrocytes with serotonin have on trophic factors synthesis?
No effect on synthesis
Based on the information provided, what is the potential role of astrocytes in the therapeutic effects of Prozac?
Synthesis of neurotrophic growth factors
What does the evidence suggest in relation to the presence of depressive symptoms in humans and animal models?
Correlation with astrocytic atrophy
How does the text explain the delayed therapeutic effect of Prozac when considering its action on astrocytes?
Gradual trophic factor production in astrocytes
What is the effect of serotonin treatment on the synthesis of neurotrophic growth factors in cultured astrocytes?
No effect on synthesis
What is the supposed mechanism of action of Prozac in the brain?
Inhibiting serotonin reuptake
Which of the following trophic factors is NOT mentioned as being increased in astrocytes treated with Fluoxetine?
GDNF
In the study presented, what effect did Prozac have on astrocytes?
Increased trophic factor production
Which brain regions showed down-regulation of GFAP levels in suicide cases, indicating astrocytic pathology?
Mediodorsal thalamus and coded nucleus
What is the primary role of astrocytes in the brain?
Support and maintenance of neurons
Which of the following is a common therapeutic effect associated with Prozac use?
Enhanced synaptic plasticity
What is the consequence of the decreased level of connexin 43 protein in stressed rats?
Decreased number of coupled cells
Which neurotransmitter system is likely impacted by Fluoxetine and Duloxetine treatments?
Serotonergic neurotransmission
In the context of astrocytes, what impact does the chronic stress have on coupled cells?
Reduces the number of coupled cells
How does chronic unpredictable stress affect trophic factors synthesis in astrocytes?
Reduces the synthesis of trophic factors
What is the primary therapeutic effect of Fluoxetine (Prozac) observed in the context of connexin 43 levels restoration?
Restores normal connexin 43 protein levels
What is the observed impact of antidepressant treatment on the diffusion distance of the dye in the rat brain?
No change in diffusion distance
Explore the impact of antidepressants like Fluoxetine and Duloxetine on the levels of connexin 43 protein and messenger RNA in stressed rats. Understand how these medications can help in restoring the reduced levels of connexin 43.
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