Effects of Antidepressants on Connexin 43 in Stressed Rats
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Questions and Answers

What is the main reason why the full therapeutic effect of Prozac may be delayed according to the text?

  • Synthesis of serotonin receptors
  • Interaction with dopamine receptors
  • Astrocytes induction of trophic factors (correct)
  • Direct modulation of GABAergic neurotransmission
  • What effect did treating cultured astrocytes with serotonin have on trophic factors synthesis?

  • Decreased synthesis
  • No effect on synthesis (correct)
  • Induced apoptosis
  • Increased synthesis
  • Based on the information provided, what is the potential role of astrocytes in the therapeutic effects of Prozac?

  • Induction of GABAergic receptors
  • Synthesis of neurotrophic growth factors (correct)
  • Direct modulation of neurotransmitter reuptake
  • Increased release of serotonin
  • What does the evidence suggest in relation to the presence of depressive symptoms in humans and animal models?

    <p>Correlation with astrocytic atrophy</p> Signup and view all the answers

    How does the text explain the delayed therapeutic effect of Prozac when considering its action on astrocytes?

    <p>Gradual trophic factor production in astrocytes</p> Signup and view all the answers

    What is the effect of serotonin treatment on the synthesis of neurotrophic growth factors in cultured astrocytes?

    <p>No effect on synthesis</p> Signup and view all the answers

    What is the supposed mechanism of action of Prozac in the brain?

    <p>Inhibiting serotonin reuptake</p> Signup and view all the answers

    Which of the following trophic factors is NOT mentioned as being increased in astrocytes treated with Fluoxetine?

    <p>GDNF</p> Signup and view all the answers

    In the study presented, what effect did Prozac have on astrocytes?

    <p>Increased trophic factor production</p> Signup and view all the answers

    Which brain regions showed down-regulation of GFAP levels in suicide cases, indicating astrocytic pathology?

    <p>Mediodorsal thalamus and coded nucleus</p> Signup and view all the answers

    What is the primary role of astrocytes in the brain?

    <p>Support and maintenance of neurons</p> Signup and view all the answers

    Which of the following is a common therapeutic effect associated with Prozac use?

    <p>Enhanced synaptic plasticity</p> Signup and view all the answers

    What is the consequence of the decreased level of connexin 43 protein in stressed rats?

    <p>Decreased number of coupled cells</p> Signup and view all the answers

    Which neurotransmitter system is likely impacted by Fluoxetine and Duloxetine treatments?

    <p>Serotonergic neurotransmission</p> Signup and view all the answers

    In the context of astrocytes, what impact does the chronic stress have on coupled cells?

    <p>Reduces the number of coupled cells</p> Signup and view all the answers

    How does chronic unpredictable stress affect trophic factors synthesis in astrocytes?

    <p>Reduces the synthesis of trophic factors</p> Signup and view all the answers

    What is the primary therapeutic effect of Fluoxetine (Prozac) observed in the context of connexin 43 levels restoration?

    <p>Restores normal connexin 43 protein levels</p> Signup and view all the answers

    What is the observed impact of antidepressant treatment on the diffusion distance of the dye in the rat brain?

    <p>No change in diffusion distance</p> Signup and view all the answers

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