Questions and Answers
Name the two drugs that fall under the SSRI class.
Fluoxetine (Prozac), Citalopram (stronger than Fluoxetine)
Name the two drugs that fall under the NARI class (Noradrenaline Reuptake Inhibitor).
Reboxetine, Maprotiline (TCA-like NARI)
Name the three drugs that fall under the SNRI class (Serotonin-Noradrenaline Reuptake Inhibitor).
Venlafaxine, Desvenlafaxine (Synthetic Metabolite), Duloxetine
List the 2 MAOI drugs (Non-selective irreversible and selective reversible).
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State the TCA that is non-selective for SERT/NET and which TCA is considered a 2nd generation TCA.
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State the TCA that is selective for NET (Norepinephrine Transporter).
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State the anti-depressant that is a NaSSA (Noradrenaline and Specific Serotonin Antidepressant).
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State the anti-depressant that is a NDRI (Noradrenaline Dopamine Reuptake Inhibitor).
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State the anti-depressant that is an agonist of Melatonin (MT1 and MT2) and antagonist at 5-HT2c receptors.
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State the anti-depressant that works as an antagonist of the Glutamine NMDA receptors.
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What is the MOA of Reserpine?
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What is the drug class of Phenelzine?
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What is the MOA of Phenelzine?
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What is the drug class of Moclobemide?
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What is the MOA of Moclobemide?
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What is the drug class of Imipramine?
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What is the MOA of Imipramine?
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What is the drug class of Amitriptyline?
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What is the MOA of Amitriptyline?
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What is the drug class of Nortriptyline?
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What is the MOA of Nortriptyline?
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What is the drug class of Desipramine?
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What is the MOA of Desipramine?
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What is the drug class of Fluoxetine?
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What is the drug class of Citalopram?
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What is the MOA of Fluoxetine?
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What is the MOA of Citalopram?
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What is the drug class of Maprotiline?
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What is the drug class of Reboxetine?
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What is the MOA of Maprotiline?
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What is the MOA of Reboxetine?
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What is the drug class of Venlafaxine?
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What is the drug class of Desvenlafaxine?
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Study Notes
Antidepressant Drug Classes
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SSRIs (Selective Serotonin Reuptake Inhibitors)
- Fluoxetine (Prozac): A widely used SSRI, effective for depression.
- Citalopram: Considered stronger than Fluoxetine.
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NARIs (Noradrenaline Reuptake Inhibitors)
- Reboxetine: One of the two main NARIs.
- Maprotiline: TCA-like NARI, less commonly used today.
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SNRIs (Serotonin-Noradrenaline Reuptake Inhibitors)
- Venlafaxine: Inhibits the reuptake of both serotonin and norepinephrine.
- Desvenlafaxine: A synthetic metabolite of Venlafaxine.
- Duloxetine: Another drug in the SNRI class.
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MAOIs (Monoamine Oxidase Inhibitors)
- Phenelzine: Non-selective and irreversible MAOI.
- Moclobemide: Selective for MAO-A, reversible in action.
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Tricyclic Antidepressants (TCAs)
- Amitriptyline: Non-selective for serotonin transporter (SERT) and norepinephrine transporter (NET).
- Nortriptyline: Considered a 2nd generation TCA with milder side effects.
- Imipramine: First generation TCA, blocks SERT and NET.
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Selective NET Inhibitors
- Desipramine: Selective for norepinephrine transporter (NET).
Other Antidepressant Mechanisms and Classes
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NaSSAs (Noradrenaline and Specific Serotonin Antidepressant)
- Mirtazapine: A unique class of antidepressants that increases norepinephrine and serotonin levels.
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NDRIs (Noradrenaline Dopamine Reuptake Inhibitors)
- Bupropion: Works by inhibiting the reuptake of both norepinephrine and dopamine.
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Other Mechanisms
- Agomelatine: Acts as a melatonin receptor agonist (MT1 and MT2) and antagonist at 5-HT2c receptors.
- Ketamine: Functions as an antagonist of NMDA receptors, showing rapid antidepressant effects.
Mechanisms of Action (MOA)
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Reserpine: Inhibits storage of norepinephrine and serotonin, leading to mood depression; supports the monoamine theory.
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Phenelzine MOA: Blocks monoamine oxidase (MAO), preventing the breakdown of monoamines like serotonin.
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Moclobemide MOA: Similar to Phenelzine, it blocks MAO-A to reduce breakdown of serotonin.
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Imipramine and Amitriptyline MOA: First-generation TCAs that prevent the reuptake of serotonin and norepinephrine, increasing availability at synapses.
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Nortriptyline MOA: Second-generation TCA with similar action to first-generation, but generally milder side effects.
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Desipramine MOA: Selectively inhibits the reuptake of norepinephrine, increasing its sustained levels.
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Fluoxetine and Citalopram MOA: Inhibition of serotonin reuptake transporters (SERT), enhancing serotonin signaling over norepinephrine.
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Maprotiline and Reboxetine MOA: Focus on blocking norepinephrine reuptake transporter (NET) more than serotonin.
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Description
Test your knowledge on the various classes of antidepressants and their mechanisms of action. This quiz covers key drugs from the SSRI, NARI, and SNRI categories, helping you to understand their uses and properties. Perfect for students and professionals in psychology or pharmacy.
