Antidepressants Drug Class & MOA Flashcards
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Questions and Answers

Name the two drugs that fall under the SSRI class.

Fluoxetine (Prozac), Citalopram (stronger than Fluoxetine)

Name the two drugs that fall under the NARI class (Noradrenaline Reuptake Inhibitor).

Reboxetine, Maprotiline (TCA-like NARI)

Name the three drugs that fall under the SNRI class (Serotonin-Noradrenaline Reuptake Inhibitor).

Venlafaxine, Desvenlafaxine (Synthetic Metabolite), Duloxetine

List the 2 MAOI drugs (Non-selective irreversible and selective reversible).

<p>Phenelzine (Non-selective irreversible), Moclobemide (MAO-A selective reversible)</p> Signup and view all the answers

State the TCA that is non-selective for SERT/NET and which TCA is considered a 2nd generation TCA.

<p>Amitriptyline (non-selective), Nortriptyline (2nd generation), Imipramine</p> Signup and view all the answers

State the TCA that is selective for NET (Norepinephrine Transporter).

<p>Desipramine</p> Signup and view all the answers

State the anti-depressant that is a NaSSA (Noradrenaline and Specific Serotonin Antidepressant).

<p>Mirtazapine</p> Signup and view all the answers

State the anti-depressant that is a NDRI (Noradrenaline Dopamine Reuptake Inhibitor).

<p>Bupropion</p> Signup and view all the answers

State the anti-depressant that is an agonist of Melatonin (MT1 and MT2) and antagonist at 5-HT2c receptors.

<p>Agomelatine</p> Signup and view all the answers

State the anti-depressant that works as an antagonist of the Glutamine NMDA receptors.

<p>Ketamine</p> Signup and view all the answers

What is the MOA of Reserpine?

<p>Inhibitor of NA &amp; 5-HT storage, depresses mood. Evidence for the monoamine theory!</p> Signup and view all the answers

What is the drug class of Phenelzine?

<p>Monoamine Oxidase Inhibitors (MAOI) - Non-selective, Irreversible</p> Signup and view all the answers

What is the MOA of Phenelzine?

<p>Blocks Monoamine Oxidase (MAO) to prevent the breakdown of monoamines such as 5-HT.</p> Signup and view all the answers

What is the drug class of Moclobemide?

<p>Monoamine Oxidase Inhibitor (MAOI) - MAO-A selective, Reversible</p> Signup and view all the answers

What is the MOA of Moclobemide?

<p>Blocks Monoamine Oxidase (MAO) found intracellularly to prevent the breakdown of monoamines such as 5-HT.</p> Signup and view all the answers

What is the drug class of Imipramine?

<p>TCA - Tricyclic Antidepressant</p> Signup and view all the answers

What is the MOA of Imipramine?

<p>(1st generation) monoamine reuptake inhibitor. Blocks SERT and NET.</p> Signup and view all the answers

What is the drug class of Amitriptyline?

<p>TCA - Tricyclic Antidepressant</p> Signup and view all the answers

What is the MOA of Amitriptyline?

<p>(1st generation) monoamine reuptake inhibitor. Blocks SERT and NET.</p> Signup and view all the answers

What is the drug class of Nortriptyline?

<p>TCA - Tricyclic Antidepressant</p> Signup and view all the answers

What is the MOA of Nortriptyline?

<p>(2nd generation) monoamine reuptake inhibitor. Blocks SERT and NET.</p> Signup and view all the answers

What is the drug class of Desipramine?

<p>TCA - Tricyclic Antidepressant</p> Signup and view all the answers

What is the MOA of Desipramine?

<p>Monoamine reuptake inhibitor. Selective for NET.</p> Signup and view all the answers

What is the drug class of Fluoxetine?

<p>SSRI - Selective Serotonin Reuptake Inhibitor</p> Signup and view all the answers

What is the drug class of Citalopram?

<p>SSRI - Selective Serotonin Reuptake Inhibitor</p> Signup and view all the answers

What is the MOA of Fluoxetine?

<p>Blocks SERT &gt; NET - SERT = Serotonin transporter, NET = Norepinephrine transporter</p> Signup and view all the answers

What is the MOA of Citalopram?

<p>Blocks SERT &gt; NET - SERT = Serotonin transporter, NET = Norepinephrine transporter</p> Signup and view all the answers

What is the drug class of Maprotiline?

<p>NARI - Noradrenaline Reuptake Inhibitor</p> Signup and view all the answers

What is the drug class of Reboxetine?

<p>NARI - Noradrenaline Reuptake Inhibitor</p> Signup and view all the answers

What is the MOA of Maprotiline?

<p>Blocks NET &gt; SERT</p> Signup and view all the answers

What is the MOA of Reboxetine?

<p>Blocks NET &gt; SERT</p> Signup and view all the answers

What is the drug class of Venlafaxine?

<p>SNRI - Serotonin and Noradrenaline Reuptake Inhibitors</p> Signup and view all the answers

What is the drug class of Desvenlafaxine?

<p>SNRI - Serotonin and Noradrenaline Reuptake Inhibitors</p> Signup and view all the answers

Study Notes

Antidepressant Drug Classes

  • SSRIs (Selective Serotonin Reuptake Inhibitors)

    • Fluoxetine (Prozac): A widely used SSRI, effective for depression.
    • Citalopram: Considered stronger than Fluoxetine.

  • NARIs (Noradrenaline Reuptake Inhibitors)

    • Reboxetine: One of the two main NARIs.
    • Maprotiline: TCA-like NARI, less commonly used today.

  • SNRIs (Serotonin-Noradrenaline Reuptake Inhibitors)

    • Venlafaxine: Inhibits the reuptake of both serotonin and norepinephrine.
    • Desvenlafaxine: A synthetic metabolite of Venlafaxine.
    • Duloxetine: Another drug in the SNRI class.

  • MAOIs (Monoamine Oxidase Inhibitors)

    • Phenelzine: Non-selective and irreversible MAOI.
    • Moclobemide: Selective for MAO-A, reversible in action.

  • Tricyclic Antidepressants (TCAs)

    • Amitriptyline: Non-selective for serotonin transporter (SERT) and norepinephrine transporter (NET).
    • Nortriptyline: Considered a 2nd generation TCA with milder side effects.
    • Imipramine: First generation TCA, blocks SERT and NET.

  • Selective NET Inhibitors

    • Desipramine: Selective for norepinephrine transporter (NET).

Other Antidepressant Mechanisms and Classes

  • NaSSAs (Noradrenaline and Specific Serotonin Antidepressant)

    • Mirtazapine: A unique class of antidepressants that increases norepinephrine and serotonin levels.

  • NDRIs (Noradrenaline Dopamine Reuptake Inhibitors)

    • Bupropion: Works by inhibiting the reuptake of both norepinephrine and dopamine.

  • Other Mechanisms

    • Agomelatine: Acts as a melatonin receptor agonist (MT1 and MT2) and antagonist at 5-HT2c receptors.
    • Ketamine: Functions as an antagonist of NMDA receptors, showing rapid antidepressant effects.

Mechanisms of Action (MOA)

  • Reserpine: Inhibits storage of norepinephrine and serotonin, leading to mood depression; supports the monoamine theory.

  • Phenelzine MOA: Blocks monoamine oxidase (MAO), preventing the breakdown of monoamines like serotonin.

  • Moclobemide MOA: Similar to Phenelzine, it blocks MAO-A to reduce breakdown of serotonin.

  • Imipramine and Amitriptyline MOA: First-generation TCAs that prevent the reuptake of serotonin and norepinephrine, increasing availability at synapses.

  • Nortriptyline MOA: Second-generation TCA with similar action to first-generation, but generally milder side effects.

  • Desipramine MOA: Selectively inhibits the reuptake of norepinephrine, increasing its sustained levels.

  • Fluoxetine and Citalopram MOA: Inhibition of serotonin reuptake transporters (SERT), enhancing serotonin signaling over norepinephrine.

  • Maprotiline and Reboxetine MOA: Focus on blocking norepinephrine reuptake transporter (NET) more than serotonin.

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Description

Test your knowledge on the various classes of antidepressants and their mechanisms of action. This quiz covers key drugs from the SSRI, NARI, and SNRI categories, helping you to understand their uses and properties. Perfect for students and professionals in psychology or pharmacy.

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