11 Questions
How does the addition of alcohol to a buffered aqueous solution affect the solubility of a weak electrolyte?
It increases the solubility of the un-ionized species.
How does alcohol affect the dissociation of a weak electrolyte in a buffered solution?
Alcohol decreases the dissociation of the weak electrolyte.
How can weakly acidic and basic drugs be brought into solution with the help of surfactants?
By solubilizing action of surface-active agents
What is one way in which complexation can influence the solubility of a substance?
Produce insoluble complexes
How does particle size affect solubility?
Solubility increases with decreasing particle size
What influence does the configuration of a molecule and crystal arrangement have on solubility?
Unsymmetrical particles are less soluble
What does the true distribution coefficient, K, represent?
The ratio of molar concentration of species common to both oil and water phases
In which phase does benzoic acid only exist as a monomer?
Peanut oil
What factor in the aqueous phase influences whether benzoic acid is unionized or ionized?
pKa of the compound
What determines the concentration of dimer in the oil phase for compounds like benzoic acid?
Type of oil
How is the observed distribution coefficient affected by the total acid concentration used in analysis?
It depends on two equilibria
Explore how the addition of alcohol to a buffered aqueous solution affects the solubility of weak electrolytes by adjusting polarity and decreasing dissociation. Understand the impact on the solubility of the drug as the dissociation constant changes.
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