Effect of Propranolol on Arrhythmia
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Questions and Answers

What is the primary action of propranolol?

  • Enhance vagal tone on the heart
  • Stimulate cardiac β-receptors
  • Release adrenaline from adrenal glands
  • Antagonize cardiac β-receptors (correct)
  • What occurs after the administration of a high dose of adrenaline?

  • Decreased heart rate
  • Increased cardiac excitability (correct)
  • Reduced arrhythmia risk
  • Enhanced vagal inhibition
  • Which of the following sequences for drug administration is correct?

  • Adrenaline, Propranolol, Atropine (correct)
  • Atropine, Propranolol, Adrenaline
  • Atropine, Adrenaline, Propranolol
  • Propranolol, Atropine, Adrenaline
  • What is the expected effect on heart rate after administering propranolol following adrenaline?

    <p>Heart rate drops to normal levels</p> Signup and view all the answers

    What is the effect of atropine when administered after propranolol?

    <p>Increased heart rate</p> Signup and view all the answers

    Which of the following descriptions best fits the action of adrenaline?

    <p>It is an α, β-agonist causing cardiac excitation.</p> Signup and view all the answers

    How does the heart rate respond during the first administration of adrenaline compared to the second administration?

    <p>Both administrations produce a fast heart rate.</p> Signup and view all the answers

    What is indicated by the presence of arrhythmia after administering adrenaline?

    <p>Cardiac autonomic stimulation</p> Signup and view all the answers

    Study Notes

    Effect of Propranolol on Adrenaline-Induced Arrhythmia

    • Adrenaline is an α and β agonist.
    • Activation of cardiac β receptors leads to cardiac excitation.
    • High doses or rapid injection of adrenaline can induce cardiac arrhythmia.
    • Propranolol is a cardiac β receptor antagonist.
    • Atropine is an M receptor antagonist in the heart. It relieves the inhibitory effect of the vagus nerve on the heart.

    Drug Administration Procedure

    • Administer 0.3 ml/kg of 0.02% adrenaline rapidly. Record ECG 5 minutes later.
    • Once ECG returns to normal, administer 0.5 ml/kg of 0.2% propranolol slowly. Record ECG 5 minutes after propranolol.
    • Repeat step one (adrenaline) and record ECG 5 minutes later.
    • Administer 1.6 ml/kg of 0.1% atropine. Record ECG 1-2 minutes later.
    • Repeat step two (propranolol) and record ECG 3 minutes after propranolol.
    • Repeat step one (adrenaline) and record ECG 5 minutes after.

    Cautions and Considerations

    • Administer adrenaline rapidly.
    • Administer propranolol slowly.
    • Analyze the difference in effects on blood pressure and heart induced by adrenaline, propranolol, and atropine.
    • Determine if administering adrenaline three times has a different effect.

    Results Summary

    Treatment Stage Heart Rate Rhythm
    1st Adrenaline Slow-fast Obvious arrhythmia
    Propranolol after 1st Adrenaline Slow Normal
    2nd Adrenaline Slow Rare abnormalities
    Atropine Faster Normal
    2nd Propranolol after 2nd Adrenaline Slow Normal
    3rd Adrenaline N/A No changes

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    Description

    This quiz covers the impact of propranolol on adrenaline-induced arrhythmia, focusing on cardiac receptor activity and drug administration procedures. Participants will learn the roles of adrenaline, propranolol, and atropine in managing arrhythmias effectively. Test your understanding of pharmacology and cardiac interventions.

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