Effect of Propranolol on Arrhythmia Induced by Adrenaline PDF

Effect of propranolol on arrhythmia induced by adrenaline Department of Pharmacology  Background 1. Adrenaline: α, β - agonist, Activation of cardiac β - receptor → cardiac excitation High dose of adrenaline or injection too fast→increase cardiac autonomic → arrhythmia. 2....

Effect of propranolol on arrhythmia induced by adrenaline Department of Pharmacology  Background 1. Adrenaline: α, β - agonist, Activation of cardiac β - receptor → cardiac excitation High dose of adrenaline or injection too fast→increase cardiac autonomic → arrhythmia. 2. Propranolol: cardiac β - receptor antagonist 3. Atropine: An M receptor antagonist of the heart→ cardiac excitation (relieving the inhibitory effect of vagus nerve on the heart) Red——Right upper white—— Left lower Black——Right lower （ connects to the earth ） Normal ECG  Sinus arrhythmia sinus tachycardia with shortened R-R interval Sinus bradycardia with prolonged R-R interval  Drug administration(in order) 1. Administrate 0.3ml/kg of 0.02% adrenaline RAPIDLY. Record the ECG 5 min after drug administration. 2. After the ECG becomes normal, administrate 0.5ml/kg of 0.2% propranolol SLOWLY. Record the ECG 5 min after drug administration. 3. Repeat step 1 and record the ECG 5 min after drug administration. 4. Administrate 1.6ml/kg of 0.1% atropine, and record the ECG 1-2 min after drug administration. 5. Repeat step 2 and record the ECG 3 min after drug administration. 6. Repeat step 1 and record the ECG 5 min after drug administration.  Cautions AND Thought 1. The administration of adrenaline should be rapidly ； 2. The administration of propranolol should be slowly. Thought ： 3. What is the difference of the effects induced by adrenaline, propranolol and atropine on blood pressure and heart? 4. Whether the effect of adrenaline administrated 3 times is different?  Results 1st Ad propranolol 2ndAd atropine 2nd 3rdAd propranolol Heart Slow-fast Slow Slow Faster No changes No rate changes Obvious Rare No Rhythm arrhythmia Normal abnormalities Normal Normal changes