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Effect of pH on Drug Solubility Experiment

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Effect of pH on Drug Solubility Experiment

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Questions and Answers

What is the equilibrium constant defined as for the process of simple dissolution of a weakly acidic drug?

K = [HA(aq)] * [HA(s)]

K = [HA(s)] + [HA(aq)]

K = [HA(s)] / [HA(aq)]

K = [HA(aq)] / [HA(s)] (correct)

What is the equilibrium constant defined as for the dissociation of a weakly acidic drug into ions?

Ka = [A-(aq)] + [HA(aq)]

Ka = [A-(aq)] / [HA(aq)] (correct)

Ka = [HA(aq)] / [A-(aq)]

Ka = [A-(aq)] * [HA(aq)]

How is the solubility (S) of a weakly acidic drug defined in terms of total concentration of solute?

S = [HA(aq)] - [A-(aq)]

S = [HA(s)] + [HA(aq)]

S = [HA(aq)] * [A-(aq)]

S = K + KKa /[H+] (correct)

What type of plot gives a straight line with gradient KKa and intercept K?

Plot of S vs 1/[H+] Signup and view all the answers

What is used to convert all the dissolved phenobarbitone to A-?

Excess base in the form of a pH 10 buffer solution Signup and view all the answers

What equation is used to obtain the concentration of A- in solution?

A = Ɛcl Signup and view all the answers

At what wavelength is the absorbance of the pH 10.0 solutions measured?

240 nm Signup and view all the answers

What is encouraged to promote recrystallization of the phenobarbitone?

Scratching the side of the flask with a glass rod Signup and view all the answers

What is used to dissolve most of the crystals in the process?

Heating on a hotplate with a buffer solution Signup and view all the answers

What is used to transfer the solid phenobarbitone to a 100 mL conical flask?

Labelled sample vials Signup and view all the answers

What should students do if there are spillages of phenobarbitone?

Notify staff Signup and view all the answers

What should students do with the saturated solutions of phenobarbitone?

Filter off the crystals under gravity Signup and view all the answers