Effect of pH on Drug Solubility Experiment
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Questions and Answers

What is the equilibrium constant defined as for the process of simple dissolution of a weakly acidic drug?

  • K = [HA(aq)] * [HA(s)]
  • K = [HA(s)] + [HA(aq)]
  • K = [HA(s)] / [HA(aq)]
  • K = [HA(aq)] / [HA(s)] (correct)

    • What is the equilibrium constant defined as for the dissociation of a weakly acidic drug into ions?

  • Ka = [A-(aq)] + [HA(aq)]
  • Ka = [A-(aq)] / [HA(aq)] (correct)
  • Ka = [HA(aq)] / [A-(aq)]
  • Ka = [A-(aq)] * [HA(aq)]

    • How is the solubility (S) of a weakly acidic drug defined in terms of total concentration of solute?

  • S = [HA(aq)] - [A-(aq)]
  • S = [HA(s)] + [HA(aq)]
  • S = [HA(aq)] * [A-(aq)]
  • S = K + KKa /[H+] (correct)

    • What type of plot gives a straight line with gradient KKa and intercept K?

    <p>Plot of S vs 1/[H+]</p> Signup and view all the answers

    What is used to convert all the dissolved phenobarbitone to A-?

    <p>Excess base in the form of a pH 10 buffer solution</p> Signup and view all the answers

    What equation is used to obtain the concentration of A- in solution?

    <p>A = Ɛcl</p> Signup and view all the answers

    At what wavelength is the absorbance of the pH 10.0 solutions measured?

    <p>240 nm</p> Signup and view all the answers

    What is encouraged to promote recrystallization of the phenobarbitone?

    <p>Scratching the side of the flask with a glass rod</p> Signup and view all the answers

    What is used to dissolve most of the crystals in the process?

    <p>Heating on a hotplate with a buffer solution</p> Signup and view all the answers

    What is used to transfer the solid phenobarbitone to a 100 mL conical flask?

    <p>Labelled sample vials</p> Signup and view all the answers

    What should students do if there are spillages of phenobarbitone?

    <p>Notify staff</p> Signup and view all the answers

    What should students do with the saturated solutions of phenobarbitone?

    <p>Filter off the crystals under gravity</p> Signup and view all the answers

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