Podcast
Questions and Answers
What is the equilibrium constant K defined by?
What is the equilibrium constant K defined by?
- [H+] / S
- S = [HA(aq)] + [A-(aq)]
- [HA(s)] / [HA(aq)]
- [HA(aq)] / [HA(s)] (correct)
What does the equilibrium constant Ka represent in the context of drug solubility?
What does the equilibrium constant Ka represent in the context of drug solubility?
- Total concentration of solute
- Rate of dissociation into ions (correct)
- Equilibrium between HA(s) and HA(aq)
- Dissolution rate of the drug
What does the equation S=K + KKa /[H+] represent in the context of drug solubility?
What does the equation S=K + KKa /[H+] represent in the context of drug solubility?
- Concentration of ionic forms
- Equilibrium between HA(s) and HA(aq)
- Equilibrium constants K and Ka (correct)
- Rate of drug solubility
What does a plot of S vs 1/[H+] yield in the context of drug solubility?
What does a plot of S vs 1/[H+] yield in the context of drug solubility?
What is used to obtain the concentration of A- in the solution?
What is used to obtain the concentration of A- in the solution?
What is the value of Ɛ in the Beer-Lambert law at a wavelength of 240nm?
What is the value of Ɛ in the Beer-Lambert law at a wavelength of 240nm?
What is the purpose of scratching the side of the flask with a glass rod?
What is the purpose of scratching the side of the flask with a glass rod?
What is added to the diluted filtrates for measurement of absorbance?
What is added to the diluted filtrates for measurement of absorbance?
How much of each filtrate is accurately pipetted into clean 100mL volumetric flasks?
How much of each filtrate is accurately pipetted into clean 100mL volumetric flasks?
What must be done if there are any spillages of phenobarbitone?
What must be done if there are any spillages of phenobarbitone?
What is used to transfer the solid phenobarbitone to a 100 mL conical flask?
What is used to transfer the solid phenobarbitone to a 100 mL conical flask?
What is used to make up the volumetric flasks to the line after adding 10mL of each filtrate?
What is used to make up the volumetric flasks to the line after adding 10mL of each filtrate?
What is the equilibrium constant K defined by in the context of drug solubility?
What is the equilibrium constant K defined by in the context of drug solubility?
What does the equilibrium constant Ka represent in the context of drug solubility?
What does the equilibrium constant Ka represent in the context of drug solubility?
What is the equation S=K + KKa /[H+] used to represent in the context of drug solubility?
What is the equation S=K + KKa /[H+] used to represent in the context of drug solubility?
What does a plot of S vs 1/[H+] yield in the context of drug solubility?
What does a plot of S vs 1/[H+] yield in the context of drug solubility?
What is the purpose of adding excess base in the form of a pH 10 buffer solution?
What is the purpose of adding excess base in the form of a pH 10 buffer solution?
What is the purpose of heating the phenobarbitone and buffer mixture on a hotplate?
What is the purpose of heating the phenobarbitone and buffer mixture on a hotplate?
What is the purpose of cooling the mixture in a water bath and thermostat at 25°C?
What is the purpose of cooling the mixture in a water bath and thermostat at 25°C?
What is the purpose of filtering off the crystals under gravity?
What is the purpose of filtering off the crystals under gravity?
Why are 10mL of each filtrate accurately pipetted into clean 100mL volumetric flasks?
Why are 10mL of each filtrate accurately pipetted into clean 100mL volumetric flasks?
What is the purpose of adding 20mL of pH 10.0 buffer to the diluted filtrates?
What is the purpose of adding 20mL of pH 10.0 buffer to the diluted filtrates?
What is measured in the experimental method at a wavelength of 240nm?
What is measured in the experimental method at a wavelength of 240nm?
What does the equilibrium constant K represent in the context of drug solubility?
What does the equilibrium constant K represent in the context of drug solubility?
What is the equation S=K + KKa /[H+] used to represent in the context of drug solubility?
What is the equation S=K + KKa /[H+] used to represent in the context of drug solubility?
What does a plot of S vs 1/[H+] yield in the context of drug solubility?
What does a plot of S vs 1/[H+] yield in the context of drug solubility?
What must be done if there are any spillages of phenobarbitone?
What must be done if there are any spillages of phenobarbitone?
What is the purpose of using a pH 10 buffer solution in the experiment?
What is the purpose of using a pH 10 buffer solution in the experiment?
What does the wavelength of 240nm represent in the experimental method?
What does the wavelength of 240nm represent in the experimental method?
Why is it important to accurately pipette 10mL of each filtrate into clean 100mL volumetric flasks?
Why is it important to accurately pipette 10mL of each filtrate into clean 100mL volumetric flasks?
What is the purpose of scratching the side of the flask with a glass rod?
What is the purpose of scratching the side of the flask with a glass rod?
What is used to transfer the solid phenobarbitone to a 100 mL conical flask?
What is used to transfer the solid phenobarbitone to a 100 mL conical flask?
What is the purpose of adding about 50 mL of the appropriate buffer to the solid phenobarbitone?
What is the purpose of adding about 50 mL of the appropriate buffer to the solid phenobarbitone?
What does the Beer-Lambert law help obtain in the experiment?
What does the Beer-Lambert law help obtain in the experiment?
Why must staff be notified of any spillages of phenobarbitone during the experiment?
Why must staff be notified of any spillages of phenobarbitone during the experiment?
Flashcards are hidden until you start studying
