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Muscle Tissue is generated by interaction of

Actin and Myosin

contractile role in addition to being able to secrete collagen

Myofibroblasts

what are the 3 single cell contractile units

Myoepithelial cells Pericytes Myofibroblasts

cytoplasm of muscle cells

Sarcoplasm

3 Multicellular contractile units

Skeletal Muscle Cardiac Muscle Smooth Muscle

component of a certain secretory glands

Myoepithelial cells

smooth muscle like cells

Pericytes

surrounding cell membrane or plasmalemma

sarcolemma

fusiform, lack striation, slow and involuntary contractions

Smooth Muscle

long, multinucleated, with cross striations, quick, forceful, voluntary

Skeletal Muscle

smooth endoplasmic reticulum

sarcoplasmic reticulum

surrounds all 3 types of muscles; contractile forces from internal contractile proteins to external lamina via link protein.

External Lamina

intercalated discs, involuntary, vigorous, and rhythmic

Cardiac Muscle

elongated muscle cells

Muscle Fibers Myocytes

process of sliding interaction of myosin filaments along actin filaments

Sliding Filament Mechanism

Functions of Muscular Tissue

Producing Body Movements Stabilizing body positions Storing and Moving Substances Generating Heat

consists of elongated muscle cells called muscle fibers or myocytes

Muscle Tissue

Usually attached to bones by tendons

Skeletal Muscle Tissue

long cylindrical fiber

Skeletal Muscle Tissue

Structures of Skeletal Muscle Fiber

Sarcolemma Nuclei Sarcoplasm

long finger like invaginations of the sarcolemma that penetrate into thesarcoplasm

Transverse tubules

found just beneath the sarcolemma

Nuclei

how many nuclei are found in each skeletal muscle fiber

100 or more

red colored protein found only in muscle; binds oxygen molecules that diffuse into muscle fibers

Myoglobin

large molecule composed of many glucose molecules; can be used for ATP Synthesis

Glycogen

lie in rows throughout the muscle fiber

Mitochondria

contractile organelles of skeletal muscle; arranged in parallel bundles

Myofibrils

fluid filled system of membranous sacs that encircles each myofibril

Sarcoplasmic reticulum

basic functional contractile unit of myofibril

Sarcomere

narrow region in center of each A band

H Zone

narrow, plate shaped regions of dense materials

Z discs

region in center of H zone that contains proteins that hold filaments together at center of sarcomere

M line

consists of long series of sarcomeres

Structure of Myofibril

dark, middle part of sarcomere

A band

lighter, less dense area of sarcomere

I band

3 layers of Skeletal Muscle

Epimysium Perimysium Endomysium

surrounds and separates individual muscle fibers from one another; consists mostly of reticular fibers

Endomysium

outer layer, encircling the entire muscle; consists of dense irregular connective tissue

Epimysium

surrounds groups of 10 to 100 or more muscle fibers, separating the bundles called fasicles; consists of dense irregular collagenous connective tissue

Perimysium

3 kinds of muscle proteins

Contractile Regulatory Structural

help switch the contraction process on and off

Regulatory Proteins

generate force during contraction

Contractile Proteins

main component of thin filament; functions as a motor protein

Actin

component of thin filament

Tropomyosin

makes up thick filament; a molecule consists of a tail and two heads

Myosin

keep thick and thin filaments of myofibrils in proper alignment

Structural Proteins

connects Z disc to M line of sarcomere

Titin

regulatory protein that is a component of thin filament

Troponin

forms M line of sarcomere; binds to titin molecules and connects adjacent filaments to one another

Myomesin

links thin filaments of sarcomere to integral membrane proteins

Dystrophin

wraps around entire length of each thin filament; helps anchor thin filaments and regulates length of thin filaments during development

Nebulin

structural proteins of Z discs that attaches to actin molecules of thin filament

a-Actinin

3 types of skeletal muscle fibers

Slow Oxidative Fast Glycolytic Fast-Oxidative Glycolytic

largest and contain large amounts of myoglobin

Fast- Oxidative Glycolytic

fibers appear dark red because they contain large amounts of myglobin

Slow Oxidative

have low myoglobin content; contain large amounts of glycogen and generate ATP

Fast Glycolytic

located in the heart and large vessels attached to the heart

Cardiac Muscle Tissue

Branched cylindrical fiber with one centrally located nucleus

Cardiac Muscle Tissue

regulatory proteins

tropomyosin and troponin

length of cardiac muscle tissue (long)

50-100um

diameter of cardiac muscle tissue (large)

10-20um

found in walls of hollow viscera, airways, blood vessels etc…

Smooth Muscle Tissue

shape of fibers

fusiform

develop from mesodermal cells

Smooth Muscle Tissue

length of smooth muscle fiber (Intermediate)

30-200um

Diameter of smooth muscular fiber (small)

3-8um

it can occur in skeletal muscle because of a population of reserve muscle satellite cells

Repair and Regeneration

rapid in smooth muscle because the cells/fibers are small and relatively less differentiated

Regeneration

Cardiac muscle lacks?

satellite cells

filled with interstitial fluid

Transverse tubules

Test your knowledge of muscle tissue cell structures, including single cell contractile units and multicellular contractile units. Explore the cytoplasm of muscle cells and components of secretory glands.

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