Dysmenorrhea: Painful Menstruation

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Questions and Answers

Which of the following physiological changes is LEAST likely to be associated with primary dysmenorrhea?

  • Decreased prostaglandin levels (correct)
  • Increased myometrial contractions
  • Increased cyclooxygenase (COX) enzyme activity
  • Heightened pain sensitivity

A 15-year-old patient has not experienced menarche. Which condition is LEAST likely to be a cause of her primary amenorrhea?

  • Turner syndrome
  • Polycystic ovary syndrome (PCOS)
  • Endometriosis (correct)
  • Hypothalamic amenorrhea

A woman experiences cessation of menses for 7 months. She is not pregnant or lactating. Which hormonal imbalance is LEAST likely to be the sole cause of her secondary amenorrhea?

  • Hyperprolactinemia
  • Decreased LH (correct)
  • Elevated FSH
  • Hypothyroidism

Which endometrial characteristic is LEAST likely to be associated with anovulatory AUB?

<p>Thin, atrophic endometrium (A)</p> Signup and view all the answers

Which hormone level is LEAST likely to be elevated in women with PCOS?

<p>Sex Hormone-Binding Globulin (SHBG) (B)</p> Signup and view all the answers

Which statement regarding hydrocele pathophysiology is most accurate?

<p>The fluid collection occurs within the tunica vaginalis. (A)</p> Signup and view all the answers

A patient presents with a painless, small, movable lump in the scrotum, superior and posterior to the testicle. Which of the following findings would LEAST support a diagnosis of spermatocele?

<p>Association with pain and tenderness (A)</p> Signup and view all the answers

Which of the following is least likely to be associated with acute bacterial prostatitis (ABP)?

<p>Asymptomatic presentation (B)</p> Signup and view all the answers

Which of the following factors is LEAST likely to be directly involved in the pathophysiology of benign prostatic hyperplasia (BPH)?

<p>Bacterial infection (D)</p> Signup and view all the answers

What cellular process is LEAST directly associated with the development of leiomyomas?

<p>Necrosis (B)</p> Signup and view all the answers

Which statement regarding the pathophysiology of endometriosis is least accurate?

<p>Retrograde menstruation is the sole cause. (D)</p> Signup and view all the answers

Which factor is LEAST likely to be associated with an increased risk of endometrial polyps?

<p>Multiparity (C)</p> Signup and view all the answers

Which of the following is LEAST likely to be a risk factor for cervical cancer?

<p>Infection with low-risk HPV types (A)</p> Signup and view all the answers

Which condition is LEAST associated with prolonged exposure to unopposed estrogen, a primary risk factor for endometrial cancer?

<p>Early menopause (B)</p> Signup and view all the answers

Which factor is LEAST likely to be associated with an increased risk of ovarian cancer?

<p>Parity (D)</p> Signup and view all the answers

Which of the following is the LEAST likely symptom of acute HIV infection?

<p>Low CD4+ cell count (C)</p> Signup and view all the answers

Which statement about Chlamydia trachomatis is LEAST accurate?

<p>It typically invades deep tissues. (D)</p> Signup and view all the answers

Which manifestation is LEAST likely to be associated with tertiary syphilis?

<p>Widespread papulosquamous rash (B)</p> Signup and view all the answers

Which of the following characteristics of breast lesions is LEAST associated with an increased risk of breast cancer?

<p>Nonproliferative lesions (B)</p> Signup and view all the answers

What is the LEAST likely presenting sign of breast cancer?

<p>Intense pain (B)</p> Signup and view all the answers

Which of the following factors is most directly responsible for the myometrial contractions observed in primary dysmenorrhea?

<p>Release of excessive prostaglandins, specifically PGF2α, during ovulatory cycles. (A)</p> Signup and view all the answers

A 13-year-old girl has not experienced menarche and shows no secondary sexual characteristics. Further investigation reveals elevated FSH levels. Which of the following is the most likely underlying cause?

<p>Gonadal dysfunction (A)</p> Signup and view all the answers

A 28-year-old woman experiences secondary amenorrhea. Her prolactin levels are significantly elevated, but she is not pregnant or lactating. Which mechanism is most likely contributing to her amenorrhea?

<p>Reduced GnRH secretion due to prolactin's inhibitory effect. (B)</p> Signup and view all the answers

During an anovulatory cycle, the endometrium becomes unstable, thicker, and more vascularized. What hormonal imbalance is most directly responsible for these endometrial changes?

<p>Lack of progesterone resulting in unopposed estrogen stimulation. (B)</p> Signup and view all the answers

A woman with PCOS presents with elevated LH levels and normal FSH levels. Which of the following is the most direct consequence of persistent LH elevation in PCOS?

<p>Stimulation of the ovaries to produce more androgens. (D)</p> Signup and view all the answers

A 45-year-old man is diagnosed with a varicocele. Which pathophysiological mechanism is most likely the primary cause of varicocele development?

<p>Incompetent or absent valves in the veins of the pampiniform plexus (A)</p> Signup and view all the answers

A patient presents with sudden, severe testicular pain, nausea, vomiting, and abdominal pain. Examination reveals an elevated and tender testicle. Which of the following pathophysiological processes is most likely responsible for these symptoms?

<p>Rotation of the testicle on its spermatic cord. (C)</p> Signup and view all the answers

Which of the following pathophysiological processes is most directly responsible for the symptoms observed in acute bacterial prostatitis (ABP)?

<p>Infection of the prostate gland by gram-negative bacteria from the gastrointestinal flora. (B)</p> Signup and view all the answers

Which of the following hormonal factors is most likely implicated in the pathophysiology of benign prostatic hyperplasia (BPH)?

<p>Increased levels of estrogen relative to androgens. (B)</p> Signup and view all the answers

Which cellular component is the primary origin of leiomyomas?

<p>Smooth muscle cells in the myometrium (D)</p> Signup and view all the answers

Which pathophysiologic process is most directly responsible for the pain associated with endometriosis?

<p>Ectopic endometrium responding to hormonal fluctuations and causing inflammation. (C)</p> Signup and view all the answers

Which of the following factors is most directly linked to the development of endometrial polyps?

<p>Advancing age and obesity. (A)</p> Signup and view all the answers

Which of the following biological processes is most directly disrupted by HPV E6 and E7 oncoproteins in the development of cervical cancer?

<p>Normal cell cycle control and apoptosis (A)</p> Signup and view all the answers

A woman with a history of prolonged estrogen-only hormone replacement therapy is at increased risk for endometrial cancer. What is the most direct pathophysiological effect of prolonged unopposed estrogen exposure on the endometrium?

<p>Endometrial hyperplasia (A)</p> Signup and view all the answers

Which of the following genetic factors is most strongly associated with an increased risk of ovarian cancer?

<p>Mutations in BRCA1 and BRCA2 genes (C)</p> Signup and view all the answers

What is the primary mechanism by which HIV establishes chronic infection after initial exposure?

<p>Latent infection of Th memory cells and macrophages (B)</p> Signup and view all the answers

Which cellular process most accurately describes how Chlamydia trachomatis establishes infection?

<p>Inflammatory reaction resulting in permanent scarring of tissues (A)</p> Signup and view all the answers

Which immunopathological mechanism is primarily responsible for the destructive lesions observed in tertiary syphilis?

<p>A severe hypersensitivity reaction to the microorganism (B)</p> Signup and view all the answers

A woman is diagnosed with atypical ductal hyperplasia (ADH). Which of the following statements best describes the significance of this diagnosis regarding breast cancer risk?

<p>ADH is a precursor to ductal carcinoma in situ (DCIS) and significantly increases breast cancer risk. (B)</p> Signup and view all the answers

Which genetic alteration is most directly involved in the pathophysiology of breast cancer development?

<p>DNA damage and genetic mutations (C)</p> Signup and view all the answers

Flashcards

Primary Dysmenorrhea

Painful menstruation typically involving recurrent pain 48-72 hours before/during menstruation, with possible symptoms like backache, anorexia, nausea, vomiting, diarrhea and headache.

Primary Amenorrhea

The absence of a first menstrual period by age 14 with no development of secondary sex characteristics or by age 16 regardless of secondary sex characteristics.

Secondary Amenorrhea

Defined as the cessation of menses for more than 6 months.

Polycystic Ovary Syndrome (PCOS)

A disorder characterized by hyperandrogenism, polycystic ovaries, and ovulatory dysfunction, often linked to insulin resistance.

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Hydrocele

Collection of fluid within the tunica vaginalis, often presenting as a painless swelling in the scrotum.

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Varicocele

Consists of dilated, tortuous veins of the pampiniform plexus, often causing a dull ache in the scrotum.

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Spermatocele

A fluid-filled cyst that develops in the epididymis.

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Testicular Torsion

Testicular torsion occurs when the testicle rotates on its spermatic cord. This twisting cuts off blood flow to the testicle, leading to ischemia.

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Cryptorchidism

The failure of one or both testicles to descend into the scrotum during fetal development.

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Prostatitis

Include acute bacterial prostatitis (ABP), chronic bacterial prostatitis (CBP), chronic pelvic pain syndrome (CPPS).

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Benign Prostatic Hyperplasia (BPH)

BPH is a common cause of lower urinary tract symptoms includes slow urinary stream, hesitancy, incomplete emptying, increased frequency, nocturia, and urgency.

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Leiomyomas

Leiomyomas develop from smooth muscle cells in the myometrium. Causes abnormal vaginal bleeding (heavy or prolonged), pelvic pain or pressure.

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Endometriosis

Endometrial tissue implants outside the uterus, most commonly on the ovaries, uterine ligaments, pouch of Douglas, and fallopian tubes

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Endometrial Polyps

Benign masses of endometrial tissue containing glands, stroma, and blood vessels. A common cause of intermenstrual bleeding or excessive menstrual bleeding.

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Cervical Cancer

Human papillomavirus (HPV) infection is the most important risk factor. Cervical cancer can be asymptomatic in early stages.

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Endometrial Cancer

The primary risk factor is prolonged exposure to unopposed estrogen. Begins in the cells lining the uterus (endometrium).

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Ovarian Cancer

The strongest risk factor is a positive family history of breast or ovarian cancer. Ovarian cancer is often asymptomatic until late in its progression.

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HIV/AIDS

Acute HIV infects dendritic cells to transfer to lymph nodes to infect T helper cells. Without treatment, the CD4+ cell count decreases, leading to AIDS.

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Herpes Simplex Virus Infection (HSV)

Transmission occurs through direct contact with lesions or infected secretions. After the initial infection, the virus becomes latent in nerve roots and can reactivate later in life, causing recurrent outbreaks.

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Chlamydia

Chlamydia trachomatis is an obligate intracellular bacterium. Infection produces an inflammatory reaction that can result in scarring of tissues.

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Dysmenorrhea Pathophysiology

Painful menstruation caused by release of excessive prostaglandins, leading to myometrial contractions, constricted blood vessels, and nerve sensitivity.

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Abnormal Uterine Bleeding (AUB)

Disruptions in hypothalamic-pituitary-ovary system causes irregular or heavy shedding, due to unstable, thicker, vascularized endometrium.

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Hydrocele Pathophysiology

Collection of fluid within the tunica vaginalis, the sac surrounding the testicle. May be congenital or acquired.

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Acute Bacterial Prostatitis (ABP) Symptoms

Presents with sudden onset of fever, chills, dysuria, frequency, urgency, and pelvic pain.

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Leiomyomas Pathophysiology

Originate from smooth muscle cells in myometrium and appear sensitive to estrogen and progesterone.

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Syphilis Pathophysiology

Infection produces a chancre lesion at the bacterial entry site, transitioning to systemic symptoms later if untreated.

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Breast Cancer Progression

Begins w/normal epithelium transforming into nonproliferative & proliferative lesions with atypia ultimately forms Carcinoma in situ (CIS).

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Study Notes

Common Risk Factors for Breast Cancer

  • Age risk increases with age, with higher risk for 65+ than <65

Pathophysiology of Sexually Transmitted Infections

  • In congenital syphilis, T. pallidum is transmitted to the fetus during pregnancy

Gonorrhea

  • Gonococci can infect the endocervical canal in women and the urethra in men.
  • Several factors facilitates bacteria into into the fallopian tubes and causes(PID) pelvic inflammatory disease.
  • The fallopian tubes causes mucosal and submucosal invasion, of ciliated epithelium, and inflammation with Bacteria adhere to sperm and are transported to the fallopian tubes.
  • Epididymitis, prostatitis, bartholinitis and endometritis are complicated infections for men and women potentially to PID

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