10 Questions
What is the primary effect of Ezetimibe?
Modest reduction in LDL-C
What is the mechanism by which Bile Acid Sequestrants reduce LDL-C levels?
By binding bile acids in the intestinal lumen
What is the range of LDL-C reduction achievable with Ezetimibe monotherapy?
15%–24%
What is the benefit of combining Ezetimibe with statin therapy?
Achieves higher reductions in LDL-C levels
Why are Bile Acid Sequestrants considered first-line therapy during pregnancy?
They are not systemically absorbed and pose no risk to the fetus
What is the mechanism by which Ezetimibe reduces LDL-C levels?
By inhibiting the NPC1L1 protein
What is a common side effect of Ezetimibe?
All of the above
What is the range of LDL-C reduction achievable with Bile Acid Sequestrants?
13%–20%
What is the effect of Bile Acid Sequestrants on hepatic synthesis of bile acids?
It increases the synthesis of bile acids from cholesterol
What is the effect of Bile Acid Sequestrants on the number of LDL receptors on hepatocyte membranes?
It increases the number of LDL receptors
This quiz covers the basics of dyslipidemia, a disorder characterized by abnormal levels of lipids and/or lipoproteins in the blood. Learn about the etiology of primary and secondary dyslipidemias, including genetic defects and acquired conditions. Test your knowledge of hypercholesterolemia, hypertriglyceridemia, and HDL-C metabolism.
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