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Dyslipidemia Therapeutics II

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Questions and Answers

What is the primary effect of Ezetimibe?

Significant reduction in HDL-C

Modest reduction in LDL-C (correct)

Marked increase in triglycerides

Elevation of ALT levels

What is the mechanism by which Bile Acid Sequestrants reduce LDL-C levels?

By inhibiting the NPC1L1 protein

By binding bile acids in the intestinal lumen (correct)

By stimulating hepatic synthesis of cholesterol

By reducing the absorption of dietary cholesterol

What is the range of LDL-C reduction achievable with Ezetimibe monotherapy?

5%–10%

25%–30%

15%–24% (correct)

35%–40%

What is the benefit of combining Ezetimibe with statin therapy?

Achieves higher reductions in LDL-C levels Signup and view all the answers

Why are Bile Acid Sequestrants considered first-line therapy during pregnancy?

They are not systemically absorbed and pose no risk to the fetus Signup and view all the answers

What is the mechanism by which Ezetimibe reduces LDL-C levels?

By inhibiting the NPC1L1 protein Signup and view all the answers

What is a common side effect of Ezetimibe?

All of the above Signup and view all the answers

What is the range of LDL-C reduction achievable with Bile Acid Sequestrants?

13%–20% Signup and view all the answers

What is the effect of Bile Acid Sequestrants on hepatic synthesis of bile acids?

It increases the synthesis of bile acids from cholesterol Signup and view all the answers

What is the effect of Bile Acid Sequestrants on the number of LDL receptors on hepatocyte membranes?

It increases the number of LDL receptors Signup and view all the answers