Dynamics of Ultrafiltratio physiology 1404 lect 1
29 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the formula to estimate the Glomerular Filtration Rate (GFR)?

  • GFR = PCr / (UCr × V)
  • GFR = PCr × V / UCr
  • GFR = UCr × V / PCr (correct)
  • GFR = UCr / (Pcr × V)

    • What is the characteristic of a substance that can be used to measure GFR?

  • It must be secreted by the nephron.
  • It must be reabsorbed by the nephron.
  • It must be produced by the kidney.
  • It must meet specific criteria, including being freely filtered across the glomerulus. (correct)

    • What is the unit of measurement for urine flow (V)?

  • milliliters per minute (mL/min) (correct)
  • millimoles per second (mmol/s)
  • liters per hour (L/h)
  • microliters per minute (μL/min)

    • What is the purpose of measuring the clearance of creatinine?

    <p>To measure the Glomerular Filtration Rate (GFR).</p> Signup and view all the answers

    What is the advantage of using inulin as a marker for GFR measurement?

    <p>It meets the criteria for a GFR marker.</p> Signup and view all the answers

    What is the relationship between the equation for estimating GFR and the equation for clearance?

    <p>The equations are identical in form.</p> Signup and view all the answers

    What is the primary reason for complete emptying of the bladder at the beginning and end of the clearance period?

    <p>To reduce possible errors introduced by urine remaining in the bladder</p> Signup and view all the answers

    What is a limitation of using creatinine clearance as a marker for GFR?

    <p>It is affected by certain drugs that inhibit tubular secretion of creatinine</p> Signup and view all the answers

    What is an advantage of using creatinine clearance over inulin clearance?

    <p>It can be measured over a longer period of time</p> Signup and view all the answers

    Why is creatinine a suitable marker for GFR?

    <p>It is always present in the blood and its concentration remains fairly constant over a 24 hour period</p> Signup and view all the answers

    What is the benefit of using creatinine clearance in patients with compromised renal function?

    <p>It overcomes some of the practical problems of inulin clearance</p> Signup and view all the answers

    How many blood samples are needed for creatinine clearance?

    <p>Only one blood sample is needed</p> Signup and view all the answers

    What is the formula for GFR in terms of Net Filtration Pressure (NFP) and ultrafiltration coefficient (Kf)?

    <p>GFR = Kf x NFP</p> Signup and view all the answers

    What is the primary reason why the rate of glomerular filtration is higher in glomerular capillaries than in systemic capillaries?

    <p>Higher ultrafiltration coefficient (Kf) in glomerular capillaries</p> Signup and view all the answers

    What is the effect of chronic uncontrolled hypertension and diabetes mellitus on the glomerular capillary membrane?

    <p>Decreases the intrinsic permeability of the membrane</p> Signup and view all the answers

    What is the unit of measurement for the ultrafiltration coefficient (Kf)?

    <p>mL/mmHg</p> Signup and view all the answers

    What is the effect of reducing the number of functional glomerular capillaries on the ultrafiltration coefficient (Kf)?

    <p>Decreases Kf</p> Signup and view all the answers

    What is the net effect of πBS on GFR?

    <p>Has no effect on GFR</p> Signup and view all the answers

    What is the unit of clearance?

    <p>ml/min</p> Signup and view all the answers

    What is the concentration of Na+ in the plasma?

    <p>145 mmol/L</p> Signup and view all the answers

    What is the volume of urine collected in 1 hour?

    <p>450 ml</p> Signup and view all the answers

    What is the unit of inulin concentration?

    <p>mg/ml</p> Signup and view all the answers

    What is the clearance of glucose in a normal individual?

    <p>0 ml/min</p> Signup and view all the answers

    What happens to a substance that is filtered but partially reabsorbed?

    <p>Its clearance is between zero and ~600 ml/min</p> Signup and view all the answers

    What is the formula for GFR?

    <p>GFR = Kf x Net Filtration Pressure (NFP)</p> Signup and view all the answers

    Which of the following changes would increase GFR?

    <p>Dilation of afferent arteriole</p> Signup and view all the answers

    What is the effect of sympathetic stimulation on GFR?

    <p>Decreases GFR</p> Signup and view all the answers

    How does AgII affect efferent and afferent arterioles?

    <p>Constricts efferent arteriole more than afferent arteriole</p> Signup and view all the answers

    What is the effect of haemorrhage on GFR?

    <p>Decreases GFR</p> Signup and view all the answers

    More Like This

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser