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Questions and Answers
What type of drug is duloxetine (Cymbalta)?
What type of drug is duloxetine (Cymbalta)?
Which of the following are therapeutic uses for duloxetine (Cymbalta)? (Select all that apply)
Which of the following are therapeutic uses for duloxetine (Cymbalta)? (Select all that apply)
What is a serious adverse effect associated with duloxetine (Cymbalta)?
What is a serious adverse effect associated with duloxetine (Cymbalta)?
Which of the following are contraindications for duloxetine (Cymbalta)? (Select all that apply)
Which of the following are contraindications for duloxetine (Cymbalta)? (Select all that apply)
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What precautions should be observed in patients taking duloxetine (Cymbalta)?
What precautions should be observed in patients taking duloxetine (Cymbalta)?
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What nursing interventions should be assessed in patients taking duloxetine (Cymbalta)?
What nursing interventions should be assessed in patients taking duloxetine (Cymbalta)?
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Improvement with duloxetine (Cymbalta) may occur in ______ to ______ weeks.
Improvement with duloxetine (Cymbalta) may occur in ______ to ______ weeks.
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What advice should be given regarding medication administration of duloxetine (Cymbalta)?
What advice should be given regarding medication administration of duloxetine (Cymbalta)?
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What is the therapeutic response expected from duloxetine (Cymbalta)?
What is the therapeutic response expected from duloxetine (Cymbalta)?
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Describe the pharmacokinetics of duloxetine (Cymbalta).
Describe the pharmacokinetics of duloxetine (Cymbalta).
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Duloxetine (Cymbalta) can be taken with St. John's Wort.
Duloxetine (Cymbalta) can be taken with St. John's Wort.
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Study Notes
Action of Duloxetine (Cymbalta)
- Classified as a serotonin-norepinephrine reuptake inhibitor (SNRI).
Therapeutic Uses for Duloxetine (Cymbalta)
- Effective for major depressive disorder.
- Used in treating neuropathic pain related to diabetic neuropathy.
- Prescribed for generalized anxiety disorder.
- Treats fibromyalgia symptoms.
- Alleviates osteoarthritis pain.
Adverse Effects of Duloxetine (Cymbalta)
- CNS effects may include neuroleptic malignant-like syndrome and seizures.
- Cardiovascular risks include thrombophlebitis and supraventricular dysrhythmia.
- Vision changes noted under EENT.
- Potential for hepatic failure within the gastrointestinal effects.
- Risk of Stevens-Johnson syndrome in integumentary system.
- Systems reactions may include anaphylaxis, angioedema, and serotonin syndrome, characterized by nausea, dizziness, facial flushing, shivering, and sweating.
Contraindications for Duloxetine (Cymbalta)
- Contraindicated in individuals with active alcohol intoxication, alcoholism, or closed-angle glaucoma.
- Not recommended for those with hepatic disease or hypersensitivity to the drug.
Precautions for Duloxetine (Cymbalta)
- Caution advised for use in children.
- Monitor for signs of suicidal ideation.
Nursing Interventions for Duloxetine (Cymbalta)
- Assess mood, sensorium, affect, and risk of suicidal tendencies in patients with depression.
- Monitor blood pressure due to potential for orthostatic hypotension.
- Conduct hepatic studies (e.g., AST, ALT, bilirubin).
- Track weight weekly.
- Recognize signs of dry mouth and withdrawal symptoms including headache and nausea.
- Discuss potential sexual dysfunction with patients.
Client Education for Duloxetine (Cymbalta)
- Inform patients that improvement may be observed in 4-8 weeks or up to 12 weeks in older adults.
- Advise to report any urinary retention.
- Caution against driving or activities requiring alertness until they know how the medication affects them.
- Strongly recommend avoidance of alcohol.
- Stress the importance of not abruptly discontinuing medication after long-term use.
- Highlight the risk of clinical deterioration and suicide risk.
- Advise the use of sunscreen due to photosensitivity.
- Encourage pregnant patients to notify their prescriber.
Therapeutic Response Expected from Duloxetine (Cymbalta)
- Aim for a decrease in symptoms of depression.
Pharmacokinetics of Duloxetine (Cymbalta)
- Well absorbed with 90% protein binding.
- Metabolized by the liver, with approximately 70% of the product recovered in urine.
- Half-life ranges from 9.2 to 19.1 hours.
- Narrow therapeutic index potentially leading to toxic side effects.
Medication Administration for Duloxetine (Cymbalta)
- Must not be broken, crushed, chewed, or sprinkled on food or mixed with liquids.
- Avoid co-administration with St. John's Wort.
Perform/Provide Aspects for Duloxetine (Cymbalta)
- Assist patients with ambulation at the beginning of therapy due to possible drowsiness and dizziness.
- Confirm oral medications are swallowed properly.
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Description
Test your knowledge about duloxetine, commonly known as Cymbalta, with this set of flashcards. The quiz covers its mechanism of action, therapeutic uses, and potential adverse effects. Ideal for students in pharmacology or healthcare fields.
