Duloxetine and its Uses

Study Notes

Drug Class

Classified as a Central Nervous System (CNS) agent and a psychotherapeutic agent.
Functions as an antidepressant and is categorized specifically as a Serotonin-Norepinephrine Reuptake Inhibitor (SNRI).

Mechanism of Action

Duloxetine operates as a selective serotonin and norepinephrine reuptake inhibitor (SSNRI).
Enhances serotonergic and noradrenergic activity in the CNS by inhibiting the reuptake of serotonin and norepinephrine.

Indications

Approved for the treatment of depression.
Also effective for managing chronic back pain.
Indicated for fibromyalgia.
Used to alleviate symptoms of diabetic neuropathy.

Drug Effect

Antidepressant effects are attributed to the dual inhibition of presynaptic neuronal uptake of serotonin and norepinephrine.
Increases serum levels of both neurotransmitters, facilitating improved mood and pain relief.

Contraindications

Not to be used in conjunction with Monoamine Oxidase Inhibitors (MAOIs).
Contraindicated in patients with uncontrolled narrow-angle glaucoma.
Assigned to Pregnancy Category C, indicating potential risk.
Caution required in lactating women and those with hypertension or heavy alcohol use.

Side Effects

Common adverse effects include fatigue and insomnia.
Gastrointestinal issues such as nausea and constipation may occur.
Other side effects include dry mouth, weight loss, decreased libido, and erectile dysfunction (ED).

Nursing Care

Important to monitor patients closely for any signs of suicidal ideation.
Regularly check blood pressure as part of ongoing patient assessment.
Be vigilant for symptoms such as anxiety, agitation, panic attacks, insomnia, irritability, hostility, mania, and hypomania.

Description

This quiz covers the pharmacological profile of Duloxetine, a Serotonin-Norepinephrine Reuptake Inhibitor (SNRI). Explore its mechanisms of action, indications for use, and potential contraindications. Test your knowledge on how this drug helps treat depression, chronic pain, and more.