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Questions and Answers
What is the mechanism of action of H2 receptor antagonists?
What is the mechanism of action of H2 receptor antagonists?
- Competitive antagonists of histamine, reducing acid secretion by approximately 70%-90% (correct)
- Irreversible antagonists of histamine, reducing acid secretion by approximately 90%-100%
- Selective agonists of histamine, increasing acid secretion by approximately 70%-90%
- Non-competitive antagonists of histamine, reducing acid secretion by approximately 50%-60%
What are the therapeutic uses of H2 receptor antagonists?
What are the therapeutic uses of H2 receptor antagonists?
- Treatment of asthma
- Treatment of irritable bowel syndrome
- Treatment of peptic ulcers and gastroesophageal reflux disease (correct)
- Treatment of Crohn's disease
What adverse effect is associated with H2 receptor antagonists?
What adverse effect is associated with H2 receptor antagonists?
- Hypertension
- Hypoglycemia
- Gynecomastia and galactorrhea (correct)
- Osteoporosis
Which drugs are used in quadruple therapy for treating peptic ulcer disease and gastroesophageal reflux disease?
Which drugs are used in quadruple therapy for treating peptic ulcer disease and gastroesophageal reflux disease?
What is the main action of proton pump inhibitors (PPIs)?
What is the main action of proton pump inhibitors (PPIs)?
Which proton pump inhibitor irreversibly inhibits the H+ -K+ -ATPase enzyme system?
Which proton pump inhibitor irreversibly inhibits the H+ -K+ -ATPase enzyme system?
What is the clinical use of misoprostol?
What is the clinical use of misoprostol?
Which mucosal protective agent is a stable analogue of prostaglandin E1?
Which mucosal protective agent is a stable analogue of prostaglandin E1?
What are the adverse effects associated with PPIs?
What are the adverse effects associated with PPIs?
What is the mechanism of action of sucralfate?
What is the mechanism of action of sucralfate?
What are the unwanted effects of bismuth subsalicylate?
What are the unwanted effects of bismuth subsalicylate?
Which antacid can cause constipation?
Which antacid can cause constipation?
What is the main adverse effect associated with antacids?
What is the main adverse effect associated with antacids?
What is the clinical use of bismuth subsalicylate?
What is the clinical use of bismuth subsalicylate?
What is the effect of elevated gastric pH on calcium carbonate absorption?
What is the effect of elevated gastric pH on calcium carbonate absorption?
Study Notes
H2 Receptor Antagonists
- Mechanism of action: Competitive inhibition of histamine action on parietal cells, reducing gastric acid secretion.
- Therapeutic uses: Treatment of gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger-Ellison syndrome.
- Adverse effect: Gynecomastia, galactorrhea, and impotence.
Quadruple Therapy
- Combination of drugs used to treat peptic ulcer disease and gastroesophageal reflux disease: H2 receptor antagonist, proton pump inhibitor, antibacterial agent, and bismuth subsalicylate.
Proton Pump Inhibitors (PPIs)
- Main action: Block the secretion of gastric acid by irreversibly inhibiting the H+ -K+ -ATPase enzyme system.
- Example: Omeprazole, which irreversibly inhibits the H+ -K+ -ATPase enzyme system.
Mucosal Protective Agents
- Clinical use of misoprostol: Prevention of NSAID-induced gastric ulcers.
- Misoprostol: A stable analogue of prostaglandin E1, used to prevent gastric ulcers.
Adverse Effects
- Adverse effects associated with PPIs: Diarrhea, headache, and nausea.
Sucralfate
- Mechanism of action: Forms a protective barrier on the surface of the ulcer, promoting healing.
Bismuth Subsalicylate
- Unwanted effects: Darkening of the stool and tongue, constipation.
- Clinical use: Treatment of peptic ulcer disease, gastroesophageal reflux disease, and traveler's diarrhea.
Antacids
- Calcium carbonate: Can cause constipation.
- Main adverse effect: Diarrhea or constipation.
- Effect of elevated gastric pH on calcium carbonate absorption: Decreased absorption.
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Description
Test your knowledge about drugs used to treat peptic ulcer disease and gastroesophageal reflux disease. Learn about antimicrobial quadruple therapy, triple therapy, and H2 receptor antagonists.
