Drugs for Epilepsy II

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Which of the following adverse effects is especially common in the elderly?

Skin rash

Hyponatremia (correct)

Diplopia

Aplastic anemia

What is the active metabolite of carbamazepine?

Felbamate

Carbamazepine-10,11-epoxide (correct)

Oxcarbazepine

Eslicarbazepine

Which of the following is a prodrug?

Eslicarbazepine

Carbamazepine

Ethosuximide

Oxcarbazepine (correct)

What is the mechanism of action of Eslicarbazepine?

Voltage-gated sodium channel blocker Signup and view all the answers

Which of the following is indicated for absence seizures?

Ethosuximide Signup and view all the answers

What is the mechanism of action of Felbamate?

Calcium channel inhibition, competitive NMDA glutamate receptor binding, GABA Signup and view all the answers

Which of the following can worsen other seizure types?

Ethosuximide Signup and view all the answers

What is the serious, rare adverse effect of Eslicarbazepine?

Pschiatric changes Signup and view all the answers

What is the FDA classification of Carbamazepine?

Strong inducer Signup and view all the answers

Which medication is known to induce drugs metabolized by CYP3A4?

Phenytoin Signup and view all the answers

What is the MOA of Lacosamide?

Stabilization of voltage-gated sodium channels Signup and view all the answers

Which medication is effective for a wide variety of seizure types?

Lamotrigine Signup and view all the answers

What is the unique PK feature of Gabapentin?

No plasma protein binding and no liver metabolism Signup and view all the answers

Which medication is a dihydrofolate reductase inhibitor?

Lamotrigine Signup and view all the answers

What is the unique feature of Brivaracetam?

Inhibition of synaptic vesicle protein SV2A Signup and view all the answers

Which medication has a caution for causing mood changes?

Levetiracetam Signup and view all the answers

What is the MOA of Phenytoin?

Blockage of high voltage-dependent calcium channels Signup and view all the answers

Which medication is available in injectable formulations?

Lacosamide Signup and view all the answers

What is the interaction between Divalproex and Lamotrigine?

Divalproex decreases Lamotrigine clearance Signup and view all the answers

Which medication has few drug-drug interactions?

Levetiracetam Signup and view all the answers

What is the primary goal of antiepileptic drug therapy?

Eliminate or reduce seizure frequency Signup and view all the answers

Which of the following drugs is an inducer of other drugs?

Carbamazepine Signup and view all the answers

What is the mechanism of action of carbamazepine?

Inhibits the generation of repetitive action potentials by blocking sodium channels Signup and view all the answers

What is a potential result of carbamazepine's autoinduction?

Lower total drug blood concentrations at high doses Signup and view all the answers

What is a common adverse effect of carbamazepine?

Dose and non-dose dependent reactions Signup and view all the answers

When is it typically recommended to initiate medication therapy for epilepsy?

After the second seizure Signup and view all the answers

Which of the following drugs is contraindicated for absence seizures?