29 Questions
Which of the following adverse effects is especially common in the elderly?
Hyponatremia
What is the active metabolite of carbamazepine?
Carbamazepine-10,11-epoxide
Which of the following is a prodrug?
Oxcarbazepine
What is the mechanism of action of Eslicarbazepine?
Voltage-gated sodium channel blocker
Which of the following is indicated for absence seizures?
Ethosuximide
What is the mechanism of action of Felbamate?
Calcium channel inhibition, competitive NMDA glutamate receptor binding, GABA
Which of the following can worsen other seizure types?
Ethosuximide
What is the serious, rare adverse effect of Eslicarbazepine?
Pschiatric changes
What is the FDA classification of Carbamazepine?
Strong inducer
Which medication is known to induce drugs metabolized by CYP3A4?
Phenytoin
What is the MOA of Lacosamide?
Stabilization of voltage-gated sodium channels
Which medication is effective for a wide variety of seizure types?
Lamotrigine
What is the unique PK feature of Gabapentin?
No plasma protein binding and no liver metabolism
Which medication is a dihydrofolate reductase inhibitor?
Lamotrigine
What is the unique feature of Brivaracetam?
Inhibition of synaptic vesicle protein SV2A
Which medication has a caution for causing mood changes?
Levetiracetam
What is the MOA of Phenytoin?
Blockage of high voltage-dependent calcium channels
Which medication is available in injectable formulations?
Lacosamide
What is the interaction between Divalproex and Lamotrigine?
Divalproex decreases Lamotrigine clearance
Which medication has few drug-drug interactions?
Levetiracetam
What is the primary goal of antiepileptic drug therapy?
Eliminate or reduce seizure frequency
Which of the following drugs is an inducer of other drugs?
Carbamazepine
What is the mechanism of action of carbamazepine?
Inhibits the generation of repetitive action potentials by blocking sodium channels
What is a potential result of carbamazepine's autoinduction?
Lower total drug blood concentrations at high doses
What is a common adverse effect of carbamazepine?
Dose and non-dose dependent reactions
When is it typically recommended to initiate medication therapy for epilepsy?
After the second seizure
Which of the following drugs is contraindicated for absence seizures?
Carbamazepine
What is a potential risk associated with antiepileptic drugs?
Suicidal behavior or ideation
What is the benefit of monotherapy in epilepsy treatment?
Reduced risk of DDIs
Learn about first-line drugs for epilepsy treatment, including their interactions and things to consider. This quiz covers Carbamazepine, Oxcarbazepine, Eslicarbazepine, and more. Test your knowledge on the goals of epilepsy treatment and how to avoid adverse effects.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
