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Questions and Answers
Which drug is a potent inhibitor of the cytochrome P450 isoenzyme CYP2D6?
Which drug is a potent inhibitor of the cytochrome P450 isoenzyme CYP2D6?
- Tramadol
- Paroxetine (correct)
- SSRIs
- O-desmethyltramadol
What is the main mechanism of action for tramadol?
What is the main mechanism of action for tramadol?
- Reduction in seizure threshold
- Inhibition of serotonin reuptake
- Opioid effect mediated by O-desmethyltramadol (correct)
- Inhibition of cytochrome P450 isoenzyme CYP2D6
What is the risk of taking tramadol and SSRIs together?
What is the risk of taking tramadol and SSRIs together?
- Unpredictable drug interactions
- Reduced analgesia
- Serotonin syndrome (correct)
- Increased risk of seizures
How do SSRIs affect the seizure threshold?
How do SSRIs affect the seizure threshold?
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