Drug-Induced Hematologic Disorders - PHAR 5367
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Questions and Answers

Which of the following is NOT listed as one of the most common drug-induced hematologic disorders?

  • Agranulocytosis
  • Aplastic anemia
  • Megaloblastic anemia
  • Leukopenia (correct)
  • What was the first drug reported to be associated with agranulocytosis?

  • Sulfanilamide (correct)
  • Morphine
  • Aspirin
  • Penicillin
  • Who is more susceptible to the hematologic effects of drugs according to the text?

  • Young people
  • Men
  • Elderly people (correct)
  • Children
  • Which drug-induced hematologic disorder is reported to be most common in the text?

    <p>Thrombocytopenia</p> Signup and view all the answers

    According to the text, what is the risk of death associated with drug-induced hematologic disorders and increasing age?

    <p>Increases</p> Signup and view all the answers

    Which of the following is NOT listed as a learning objective for the Integrated Hematology/Oncology Module - PHAR 5367?

    <p>Identify all drugs that can lead to common hematologic disorders</p> Signup and view all the answers

    Which of the following is a recommended method for confirming a diagnosis of drug-induced hematologic disorders?

    <p>Conducting in vitro studies with the offending agent and patient’s blood</p> Signup and view all the answers

    What is the leading cause of death associated with drug-induced hematologic disorders?

    <p>Aplastic anemia</p> Signup and view all the answers

    What is the approximate percentage of patients who receive heparin and develop heparin-induced thrombocytopenia (HIT)?

    <p>5%</p> Signup and view all the answers

    Which of the following is NOT a criterion for diagnosing drug-induced aplastic anemia?

    <p>Platelet count of ≤ 100,000 cells/mm3</p> Signup and view all the answers

    At what percentage of reticulocyte count is a hemoglobin level of ≤ 10 g/dL considered as one of the criteria for diagnosing drug-induced aplastic anemia?

    <p>&lt;= 30,000 cells/mm3</p> Signup and view all the answers

    What type of cells do progenitor cells differentiate into?

    <p>All types of blood cells</p> Signup and view all the answers

    Which of the following is characteristic of drug-induced aplastic anemia?

    <p>Hypocellular bone marrow</p> Signup and view all the answers

    What is the recommended approach regarding lab confirmation for interrupting/discontinuing therapy for drug-induced hematologic disorders?

    <p>Lab confirmation is not necessary before interrupting therapy</p> Signup and view all the answers

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