Drug-Induced Hematologic Disorders - PHAR 5367

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Questions and Answers

Which of the following is NOT listed as one of the most common drug-induced hematologic disorders?

  • Agranulocytosis
  • Aplastic anemia
  • Megaloblastic anemia
  • Leukopenia (correct)

What was the first drug reported to be associated with agranulocytosis?

  • Sulfanilamide (correct)
  • Morphine
  • Aspirin
  • Penicillin

Who is more susceptible to the hematologic effects of drugs according to the text?

  • Young people
  • Men
  • Elderly people (correct)
  • Children

Which drug-induced hematologic disorder is reported to be most common in the text?

<p>Thrombocytopenia (D)</p> Signup and view all the answers

According to the text, what is the risk of death associated with drug-induced hematologic disorders and increasing age?

<p>Increases (A)</p> Signup and view all the answers

Which of the following is NOT listed as a learning objective for the Integrated Hematology/Oncology Module - PHAR 5367?

<p>Identify all drugs that can lead to common hematologic disorders (B)</p> Signup and view all the answers

Which of the following is a recommended method for confirming a diagnosis of drug-induced hematologic disorders?

<p>Conducting in vitro studies with the offending agent and patient’s blood (C)</p> Signup and view all the answers

What is the leading cause of death associated with drug-induced hematologic disorders?

<p>Aplastic anemia (D)</p> Signup and view all the answers

What is the approximate percentage of patients who receive heparin and develop heparin-induced thrombocytopenia (HIT)?

<p>5% (D)</p> Signup and view all the answers

Which of the following is NOT a criterion for diagnosing drug-induced aplastic anemia?

<p>Platelet count of ≤ 100,000 cells/mm3 (A)</p> Signup and view all the answers

At what percentage of reticulocyte count is a hemoglobin level of ≤ 10 g/dL considered as one of the criteria for diagnosing drug-induced aplastic anemia?

<p>&lt;= 30,000 cells/mm3 (C)</p> Signup and view all the answers

What type of cells do progenitor cells differentiate into?

<p>All types of blood cells (D)</p> Signup and view all the answers

Which of the following is characteristic of drug-induced aplastic anemia?

<p>Hypocellular bone marrow (B)</p> Signup and view all the answers

What is the recommended approach regarding lab confirmation for interrupting/discontinuing therapy for drug-induced hematologic disorders?

<p>Lab confirmation is not necessary before interrupting therapy (C)</p> Signup and view all the answers

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