15 Questions
What is the primary concern about St. John's Wort with regard to medications?
It reduces the effects of medications
Which of the following medications is likely to be affected by St. John's Wort?
Antidepressants
What is the mechanism by which St. John's Wort interacts with medications?
It induces the metabolism of medications
What is the potential consequence of taking St. John's Wort with certain medications?
Increased risk of side effects
Why is it important to consult a healthcare professional before taking St. John's Wort?
To monitor for potential interactions with medications
How should St. John's Wort be approached in terms of medication?
The same way as prescribed pharmaceuticals
What is the implication of St. John's Wort being an active medication?
It can interact with other medications
Why is it important to approach St. John's Wort with caution?
Because it is a potent medication
What does the classification of St. John's Wort as an active medication imply?
It should be used with caution
What is the significance of St. John's Wort being treated like prescribed pharmaceuticals?
It should be used with caution and under guidance
What is the effect of St. John's Wort on the efficacy of co-medications?
It reduces the efficacy of co-medications
Which CYP450 isozymes are induced by St. John's Wort in a clinically relevant manner?
CYP3A4 and CYP2B6
What type of interaction does St. John's Wort have with medications?
Pharmacokinetic interaction
What is the effect of St. John's Wort on the metabolism of medications?
It increases the metabolism of medications
Which of the following is a consequence of St. John's Wort's effect on CYP450 isozymes?
Reduced efficacy of medications
Study Notes
Drug-Herb Interactions
- St. John's wort is a potent inducer of CYP3A4 and CYP2B6, as well as many other CYP450 isozymes.
- This results in a clinically relevant reduction in the efficacy of co-medications due to pharmacokinetic interactions.
- St. John's wort is an active medication and should be treated with the same caution as prescribed pharmaceuticals.
This quiz covers the pharmacokinetic interactions of St John's Wort, a potent inducer of CYP3A4 and CYP2B6, and its effects on co-medications. Test your knowledge of drug-herb interactions and their clinical relevance.
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