Podcast
Questions and Answers
What is the primary concern about St. John's Wort with regard to medications?
What is the primary concern about St. John's Wort with regard to medications?
- It only interacts with herbal supplements
- It enhances the effects of medications
- It has no impact on medications
- It reduces the effects of medications (correct)
Which of the following medications is likely to be affected by St. John's Wort?
Which of the following medications is likely to be affected by St. John's Wort?
- Antidepressants (correct)
- Vitamin supplements
- Blood pressure medications
- Antibiotics
What is the mechanism by which St. John's Wort interacts with medications?
What is the mechanism by which St. John's Wort interacts with medications?
- It only affects the absorption of medications
- It has no effect on medication metabolism
- It inhibits the metabolism of medications
- It induces the metabolism of medications (correct)
What is the potential consequence of taking St. John's Wort with certain medications?
What is the potential consequence of taking St. John's Wort with certain medications?
Why is it important to consult a healthcare professional before taking St. John's Wort?
Why is it important to consult a healthcare professional before taking St. John's Wort?
How should St. John's Wort be approached in terms of medication?
How should St. John's Wort be approached in terms of medication?
What is the implication of St. John's Wort being an active medication?
What is the implication of St. John's Wort being an active medication?
Why is it important to approach St. John's Wort with caution?
Why is it important to approach St. John's Wort with caution?
What does the classification of St. John's Wort as an active medication imply?
What does the classification of St. John's Wort as an active medication imply?
What is the significance of St. John's Wort being treated like prescribed pharmaceuticals?
What is the significance of St. John's Wort being treated like prescribed pharmaceuticals?
What is the effect of St. John's Wort on the efficacy of co-medications?
What is the effect of St. John's Wort on the efficacy of co-medications?
Which CYP450 isozymes are induced by St. John's Wort in a clinically relevant manner?
Which CYP450 isozymes are induced by St. John's Wort in a clinically relevant manner?
What type of interaction does St. John's Wort have with medications?
What type of interaction does St. John's Wort have with medications?
What is the effect of St. John's Wort on the metabolism of medications?
What is the effect of St. John's Wort on the metabolism of medications?
Which of the following is a consequence of St. John's Wort's effect on CYP450 isozymes?
Which of the following is a consequence of St. John's Wort's effect on CYP450 isozymes?
Study Notes
Drug-Herb Interactions
- St. John's wort is a potent inducer of CYP3A4 and CYP2B6, as well as many other CYP450 isozymes.
- This results in a clinically relevant reduction in the efficacy of co-medications due to pharmacokinetic interactions.
- St. John's wort is an active medication and should be treated with the same caution as prescribed pharmaceuticals.
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Description
This quiz covers the pharmacokinetic interactions of St John's Wort, a potent inducer of CYP3A4 and CYP2B6, and its effects on co-medications. Test your knowledge of drug-herb interactions and their clinical relevance.
