Podcast
Questions and Answers
What is one of the reasons for a long half-life of a drug in the body?
What is one of the reasons for a long half-life of a drug in the body?
- Small volume of distribution
- High drug metabolism rate
- Favorable molecular properties for rapid elimination
- Low degree of protein binding (correct)
Why does diazepam have a long elimination half-life?
Why does diazepam have a long elimination half-life?
- Small volume of distribution
- Low lipophilicity
- Extensive drug metabolism
- Low extraction ratio (correct)
What is the main cause for the longer elimination half-life of diazepam in some subjects?
What is the main cause for the longer elimination half-life of diazepam in some subjects?
- Small volume of distribution
- Genetic polymorphism affecting drug clearance (correct)
- Large extraction ratio
- High drug metabolism rate
Which factor contributes to the variations in diazepam metabolism among individuals?
Which factor contributes to the variations in diazepam metabolism among individuals?
In subjects who are fast metabolizers, what still contributes to the long elimination half-lives of diazepam?
In subjects who are fast metabolizers, what still contributes to the long elimination half-lives of diazepam?
What is the impact of drug protein binding on the clearance and half-life of diazepam?
What is the impact of drug protein binding on the clearance and half-life of diazepam?
How does a decrease in protein binding affect drug distribution?
How does a decrease in protein binding affect drug distribution?
What impact does an increased free drug concentration have on drug distribution?
What impact does an increased free drug concentration have on drug distribution?
Which equation is used to relate VD, Cl, and half-life of drugs?
Which equation is used to relate VD, Cl, and half-life of drugs?
What does an increase in free drug concentration lead to in terms of pharmacologic effects?
What does an increase in free drug concentration lead to in terms of pharmacologic effects?
How does a decrease in protein binding affect the metabolism of a drug?
How does a decrease in protein binding affect the metabolism of a drug?
In pharmacokinetics, how would a lower total steady-state drug concentration but similar steady-state free drug concentration be explained?
In pharmacokinetics, how would a lower total steady-state drug concentration but similar steady-state free drug concentration be explained?
What is the primary factor contributing to the loss of drug from the receptor site?
What is the primary factor contributing to the loss of drug from the receptor site?
How can rapid IV injection affect the intensity of action of highly protein-bound drugs?
How can rapid IV injection affect the intensity of action of highly protein-bound drugs?
What was the observed effect on the hypotensive effect of diazoxide when injected rapidly IV compared to a slower injection?
What was the observed effect on the hypotensive effect of diazoxide when injected rapidly IV compared to a slower injection?
What was the free diazoxide serum level when the serum levels were 100 mg/mL?
What was the free diazoxide serum level when the serum levels were 100 mg/mL?
How did the slow injection of diazoxide affect its free serum level?
How did the slow injection of diazoxide affect its free serum level?
What factor contributed to the transient high free diazoxide concentration after a rapid IV injection?
What factor contributed to the transient high free diazoxide concentration after a rapid IV injection?
