12 Questions
Which of the following is NOT a mechanism by which food can interact with drugs to affect their absorption?
Directly binding to the drug and preventing its absorption
Which of the following is an example of a pharmacodynamic interaction between food and drugs?
Some foods decreasing or increasing drug effects and toxicity by interfering with drug actions and mechanisms
How do flavonoids in grapefruit juice and orange juice affect the bioavailability of anticancer drugs?
They inhibit P-glycoprotein, decreasing drug efflux from cells and increasing bioavailability
How does a high-salt diet affect the excretion of lithium?
A high-salt diet decreases the reabsorption of lithium in the kidney tubules, leading to increased lithium excretion
How does the pH of urine affect the half-life (t1/2) of acidic drugs?
Acidic urine increases the t1/2 of acidic drugs because the drug remains in its unionized form
Which of the following is an example of a food-drug interaction involving transporters in the gastrointestinal tract?
Green tea inhibiting organic anion transporting polypeptides, resulting in reduced nadolol plasma concentration
Which of the following is NOT a mechanism by which food can affect the absorption of drugs through pharmacokinetic interactions?
Inhibiting the activity of drug-metabolizing enzymes
Which of the following statements is TRUE regarding the effect of food on drug absorption?
Food can increase or decrease drug absorption depending on the specific drug and food components.
Which of the following examples illustrates a pharmacokinetic interaction involving drug absorption due to food?
Milk decreasing the absorption of tetracycline antibiotics by binding to them and forming insoluble complexes.
Which of the following drugs requires an acidic environment for optimal absorption, and thus can be affected by food that alters the gastrointestinal pH?
Ketoconazole
Which of the following statements is TRUE regarding the effect of food on the absorption of griseofulvin?
The absorption of griseofulvin is increased by the presence of fat in the food.
Which of the following drugs is an example of a pharmacokinetic interaction where food decreases its absorption?
Azithromycin
Learn about drug-food interactions and how they can alter the kinetics and dynamics of drugs. Explore the mechanisms such as pharmacokinetic and pharmacodynamic interactions. Understand how these interactions can impact the absorption, blood levels, effects, and toxicities of drugs.
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