Podcast
Questions and Answers
Which of the following is NOT a mechanism by which food can interact with drugs to affect their absorption?
Which of the following is NOT a mechanism by which food can interact with drugs to affect their absorption?
- Directly binding to the drug and preventing its absorption (correct)
- Forming complexes with the drugs that are less easily absorbed
- Inhibiting cytochrome P-450 metabolism of the drugs
- Inhibiting enteric esterase activity to increase stability of ester prodrugs
Which of the following is an example of a pharmacodynamic interaction between food and drugs?
Which of the following is an example of a pharmacodynamic interaction between food and drugs?
- Organic anion transporting polypeptides facilitating the uptake of drugs in the body
- Grapefruit juice inhibiting cytochrome P-450 metabolism of antihypertensive drugs
- Some foods decreasing or increasing drug effects and toxicity by interfering with drug actions and mechanisms (correct)
- Esterases in the intestine metabolizing inactive prodrugs to their active form
How do flavonoids in grapefruit juice and orange juice affect the bioavailability of anticancer drugs?
How do flavonoids in grapefruit juice and orange juice affect the bioavailability of anticancer drugs?
- They inhibit P-glycoprotein, decreasing drug efflux from cells and increasing bioavailability (correct)
- They inhibit cytochrome P-450, increasing drug metabolism and reducing bioavailability
- They inhibit organic anion transporting polypeptides, decreasing drug uptake and reducing bioavailability
- They form complexes with the anticancer drugs, reducing their absorption
How does a high-salt diet affect the excretion of lithium?
How does a high-salt diet affect the excretion of lithium?
How does the pH of urine affect the half-life (t1/2) of acidic drugs?
How does the pH of urine affect the half-life (t1/2) of acidic drugs?
Which of the following is an example of a food-drug interaction involving transporters in the gastrointestinal tract?
Which of the following is an example of a food-drug interaction involving transporters in the gastrointestinal tract?
Which of the following is NOT a mechanism by which food can affect the absorption of drugs through pharmacokinetic interactions?
Which of the following is NOT a mechanism by which food can affect the absorption of drugs through pharmacokinetic interactions?
Which of the following statements is TRUE regarding the effect of food on drug absorption?
Which of the following statements is TRUE regarding the effect of food on drug absorption?
Which of the following examples illustrates a pharmacokinetic interaction involving drug absorption due to food?
Which of the following examples illustrates a pharmacokinetic interaction involving drug absorption due to food?
Which of the following drugs requires an acidic environment for optimal absorption, and thus can be affected by food that alters the gastrointestinal pH?
Which of the following drugs requires an acidic environment for optimal absorption, and thus can be affected by food that alters the gastrointestinal pH?
Which of the following statements is TRUE regarding the effect of food on the absorption of griseofulvin?
Which of the following statements is TRUE regarding the effect of food on the absorption of griseofulvin?
Which of the following drugs is an example of a pharmacokinetic interaction where food decreases its absorption?
Which of the following drugs is an example of a pharmacokinetic interaction where food decreases its absorption?
