30 Questions
Which of the following is NOT a potential issue with plastic packaging materials?
Increased stability of the drug product due to the barrier properties of the plastic
Which of the following statements about the effect of solvents on polyvinyl chloride (PVC) is correct?
Solvents cause the plasticizer in PVC to be extracted, leaving the plastic hard and stiff.
What is the primary mechanism by which permeation can affect a drug product in a plastic container?
Entry of water vapor and oxygen through the plastic wall, which can lead to hydrolysis and oxidation of the drug.
What is the primary effect of adding coloring agents in relatively small quantities to plastic formulations?
It can cause the coloring agents to migrate into a parenteral solution and have a toxic effect.
Which of the following is a potential consequence of the loss of content through the container walls of a polyethylene container?
Deformation of the container due to permeation of gases and vapors.
What is the primary effect of oils on the mechanical properties of polyethylene?
They have a softening effect on polyethylene.
What is the primary function of enteric-coated tablets in pharmaceutical dosage forms?
Prevent drug molecules from exposure to gastric juice
Which type of dosage form is designed to bypass the first-pass metabolism?
Topical dosage forms
What is the purpose of taste-masked suspensions in pharmaceutical formulations?
Mask undesirable taste of drug substances
Which dosage form is most suitable for administering poorly water-soluble drugs?
Suspensions
What is the key function of modified-release tablets in drug delivery?
Provide predetermined rate and prolonged therapeutic effect
Which pharmaceutical dosage form aims to target drug release at specific physiological sites?
Targeted-release tablets
What is a key consideration when selecting pharmaceutical packaging materials?
Biological contamination
Which factor is NOT mentioned as a manufacturing consideration?
Consumer preferences
Why is it important for pharmaceutical packaging materials to carry correct information?
To identify the product
What is a risk associated with substandard packaging materials according to the text?
Formation of hazardous materials
Which primary function is attributed to pharmaceutical packaging materials in the text?
Protecting against physical damage
What is one of the purposes of studying the stability of pharmaceutical products in packaging materials?
Determining the effectiveness of protection provided by the materials
What is a primary requirement for packaging materials in pharmaceutical products?
They must be approved by regulatory agencies like the FDA
Which of the following is a common packaging method for solid dosage forms?
Plastic bottles
What is the primary purpose of packaging in pharmaceutical products?
To preserve the physical properties and protect against damage
Which of the following dosage forms is typically packaged in collapsible tubes or wide-mouthed jars?
Semi-solid dosage forms
What is the purpose of tertiary packaging in pharmaceutical products?
To provide additional protection during transportation
Which of the following is NOT a requirement for ideal packaging in pharmaceutical products?
It must alter the identity of the product
What effect does an increase in temperature have on the permeability of gas through plastic?
Increase
Why are hydrophobic materials like polyethylene better barriers to water vapor than hydrophilic materials like nylon?
They repel water
Why might the aroma of cosmetic products become objectionable when stored in plastic containers?
Ingredients passing through container walls
What can happen to certain water-in-oil emulsions if stored in a hydrophobic plastic bottle?
Oil phase migrates into the plastic
Why might a tube with an epoxy lining cost more than the same uncoated tube?
Improved drug product compatibility
What is a potential solution if a drug product is not compatible with bare metal used in packaging?
Flushing the interior with wax-type formulations
Test your knowledge on pharmaceutical dosage forms and their ideal requirements, including protecting drug molecules from gastric juice, ensuring safe delivery to the sites of action, and masking taste or odor. Explore different forms like enteric-coated tablets, inhalational dosage forms, and more.
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