Drug Dosage Forms Quiz

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Which of the following is NOT a potential issue with plastic packaging materials?

Softening of the plastic due to oil exposure

Leaching of additives into the drug product

Deformation of the container due to gas permeation

Increased stability of the drug product due to the barrier properties of the plastic (correct)

Which of the following statements about the effect of solvents on polyvinyl chloride (PVC) is correct?

Solvents cause the plasticizer in PVC to be extracted, leaving the plastic hard and stiff. (correct)

Solvents have no effect on the plasticizer in PVC.

Solvents have no effect on the mechanical properties of PVC.

Solvents soften the PVC and increase its flexibility.

What is the primary mechanism by which permeation can affect a drug product in a plastic container?

Softening of the plastic due to the permeation of oils or solvents.

Deformation of the plastic container due to gas permeation.

Entry of water vapor and oxygen through the plastic wall, which can lead to hydrolysis and oxidation of the drug. (correct)

Leaching of additives from the plastic into the drug product.

What is the primary effect of adding coloring agents in relatively small quantities to plastic formulations?

It can cause the coloring agents to migrate into a parenteral solution and have a toxic effect. Signup and view all the answers

Which of the following is a potential consequence of the loss of content through the container walls of a polyethylene container?

Deformation of the container due to permeation of gases and vapors. Signup and view all the answers

What is the primary effect of oils on the mechanical properties of polyethylene?

They have a softening effect on polyethylene. Signup and view all the answers

What is the primary function of enteric-coated tablets in pharmaceutical dosage forms?

Prevent drug molecules from exposure to gastric juice Signup and view all the answers

Which type of dosage form is designed to bypass the first-pass metabolism?

Topical dosage forms Signup and view all the answers

What is the purpose of taste-masked suspensions in pharmaceutical formulations?

Mask undesirable taste of drug substances Signup and view all the answers

Which dosage form is most suitable for administering poorly water-soluble drugs?

Suspensions Signup and view all the answers

What is the key function of modified-release tablets in drug delivery?

Provide predetermined rate and prolonged therapeutic effect Signup and view all the answers

Which pharmaceutical dosage form aims to target drug release at specific physiological sites?

Targeted-release tablets Signup and view all the answers

What is a key consideration when selecting pharmaceutical packaging materials?

Biological contamination Signup and view all the answers

Which factor is NOT mentioned as a manufacturing consideration?

Consumer preferences Signup and view all the answers

Why is it important for pharmaceutical packaging materials to carry correct information?

To identify the product Signup and view all the answers

What is a risk associated with substandard packaging materials according to the text?

Formation of hazardous materials Signup and view all the answers

Which primary function is attributed to pharmaceutical packaging materials in the text?

Protecting against physical damage Signup and view all the answers

What is one of the purposes of studying the stability of pharmaceutical products in packaging materials?

Determining the effectiveness of protection provided by the materials Signup and view all the answers

What is a primary requirement for packaging materials in pharmaceutical products?

They must be approved by regulatory agencies like the FDA Signup and view all the answers

Which of the following is a common packaging method for solid dosage forms?

Plastic bottles Signup and view all the answers

What is the primary purpose of packaging in pharmaceutical products?

To preserve the physical properties and protect against damage Signup and view all the answers

Which of the following dosage forms is typically packaged in collapsible tubes or wide-mouthed jars?

Semi-solid dosage forms Signup and view all the answers

What is the purpose of tertiary packaging in pharmaceutical products?

To provide additional protection during transportation Signup and view all the answers

Which of the following is NOT a requirement for ideal packaging in pharmaceutical products?

It must alter the identity of the product Signup and view all the answers

What effect does an increase in temperature have on the permeability of gas through plastic?

Increase Signup and view all the answers

Why are hydrophobic materials like polyethylene better barriers to water vapor than hydrophilic materials like nylon?

They repel water Signup and view all the answers

Why might the aroma of cosmetic products become objectionable when stored in plastic containers?

Ingredients passing through container walls Signup and view all the answers

What can happen to certain water-in-oil emulsions if stored in a hydrophobic plastic bottle?

Oil phase migrates into the plastic Signup and view all the answers

Why might a tube with an epoxy lining cost more than the same uncoated tube?

Improved drug product compatibility Signup and view all the answers

What is a potential solution if a drug product is not compatible with bare metal used in packaging?

Flushing the interior with wax-type formulations Signup and view all the answers