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16 Questions

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Drug Distribution Rate Quiz

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Questions and Answers

Which factor influences the rate at which tissues take up drugs during distribution?

Composition of the drug

Size of the tissues

Perfusion rates of the tissues (correct)

Color of the tissues

What happens to the tissue/plasma concentration ratio as distribution proceeds?

It decreases

It increases (correct)

It fluctuates

It remains constant

Which group of tissues typically have extremely rapid drug uptake?

Heart, liver, and kidneys (correct)

Skin and cartilage

Muscles and bones

Lungs and brain

Why are compartments used in drug distribution models?

To group tissues with similar drug uptake rates together Signup and view all the answers

What does it mean for a compartment to be homogeneous?

The drug concentration is uniform throughout the compartment Signup and view all the answers

How are the number of compartments selected for a particular drug determined?

Based on the behavior of plasma concentrations observed over time Signup and view all the answers

What is the significance of tissue/perfusion rates in drug distribution?

Tissues take up drugs at different rates based on their perfusion rates. Signup and view all the answers

Explain the concept of tissue/plasma concentration ratio in drug distribution.

The tissue/plasma concentration ratio increases in each tissue until reaching equilibrium. Signup and view all the answers

Describe the role of compartments in drug distribution models.

Compartments are imaginary units that consist of tissues with similar rates of drug uptake. Signup and view all the answers

Why are well-perfused tissues like the heart, liver, and kidneys important in drug distribution?

Well-perfused tissues have extremely rapid drug uptake rates. Signup and view all the answers

What distinguishes the central compartment in drug distribution models?

The central compartment represents tissues with rapid and uniform drug distribution. Signup and view all the answers

How does the rate of drug uptake differ between well-perfused tissues and other tissues?

Well-perfused tissues have faster drug uptake compared to other tissues. Signup and view all the answers

Explain why some tissues exhibit extremely slow drug uptake during distribution.

Certain tissues may have slow drug uptake due to slow partitioning of the drug. Signup and view all the answers

What determines the number of compartments selected for a particular drug in distribution models?

The number of compartments is based on the behavior of plasma concentrations observed over time. Signup and view all the answers

How are compartments defined in drug distribution models?

Compartments consist of tissues that exhibit similar rates of drug uptake. Signup and view all the answers

Why is it important for drug concentrations to be uniform throughout a compartment?

Uniform drug concentrations within a compartment ensure homogeneity. Signup and view all the answers