16 Questions
Which factor influences the rate at which tissues take up drugs during distribution?
Perfusion rates of the tissues
What happens to the tissue/plasma concentration ratio as distribution proceeds?
It increases
Which group of tissues typically have extremely rapid drug uptake?
Heart, liver, and kidneys
Why are compartments used in drug distribution models?
To group tissues with similar drug uptake rates together
What does it mean for a compartment to be homogeneous?
The drug concentration is uniform throughout the compartment
How are the number of compartments selected for a particular drug determined?
Based on the behavior of plasma concentrations observed over time
What is the significance of tissue/perfusion rates in drug distribution?
Tissues take up drugs at different rates based on their perfusion rates.
Explain the concept of tissue/plasma concentration ratio in drug distribution.
The tissue/plasma concentration ratio increases in each tissue until reaching equilibrium.
Describe the role of compartments in drug distribution models.
Compartments are imaginary units that consist of tissues with similar rates of drug uptake.
Why are well-perfused tissues like the heart, liver, and kidneys important in drug distribution?
Well-perfused tissues have extremely rapid drug uptake rates.
What distinguishes the central compartment in drug distribution models?
The central compartment represents tissues with rapid and uniform drug distribution.
How does the rate of drug uptake differ between well-perfused tissues and other tissues?
Well-perfused tissues have faster drug uptake compared to other tissues.
Explain why some tissues exhibit extremely slow drug uptake during distribution.
Certain tissues may have slow drug uptake due to slow partitioning of the drug.
What determines the number of compartments selected for a particular drug in distribution models?
The number of compartments is based on the behavior of plasma concentrations observed over time.
How are compartments defined in drug distribution models?
Compartments consist of tissues that exhibit similar rates of drug uptake.
Why is it important for drug concentrations to be uniform throughout a compartment?
Uniform drug concentrations within a compartment ensure homogeneity.
Test your knowledge on the rate of drug distribution in the body, how different tissues take up drugs, and the concept of equilibrium in tissue/plasma concentration ratios. Understand the role of compartments in drug distribution processes.
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