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Questions and Answers
What is the definition of absolute bioavailability (Fabs)?
What is the definition of absolute bioavailability (Fabs)?
- Fabs = Fraction of administered dose that is delivered to the systemic circulation
- Fabs = The bioavailability of a drug when administered via an intravascular dosage form compared to the bioavailability of the same drug administered IV
- Fabs = (AUC dosage A/AUC dosage B) × (Dose B/Dose A)
- Fabs = (AUC non-IV/AUC IV) × (Dose IV/Dose non-IV) (correct)
What is the formula used to calculate the adjusted daily dose of a drug that is eliminated exclusively by the kidneys?
What is the formula used to calculate the adjusted daily dose of a drug that is eliminated exclusively by the kidneys?
- Adjusted daily dose = (X0)NR * (Dose IV/Dose non-IV)
- Adjusted daily dose = (X0)NR * Bioavailability (F)
- Adjusted daily dose = (X0)NR * Normal creatinine clearance / Patient's creatinine clearance
- Adjusted daily dose = (X0)NR * Patient's creatinine clearance / Normal creatinine clearance (correct)
What is the definition of relative (comparative) bioavailability (Frel)?
What is the definition of relative (comparative) bioavailability (Frel)?
- Frel = (AUC non-IV/AUC IV) × (Dose IV/Dose non-IV)
- Frel = The bioavailability of a drug when administered via an extravascular dosage form compared to the bioavailability of the same drug administered IV
- Frel = (AUC dosage A/AUC dosage B) × (Dose B/Dose A) (correct)
- Frel = Fraction of administered dose that is delivered to the systemic circulation
Which of the following is NOT a factor affecting bioavailability?
Which of the following is NOT a factor affecting bioavailability?
Which of the following best describes glomerular filtration?
Which of the following best describes glomerular filtration?
What is the primary mechanism by which drugs are eliminated from the body when they are being eliminated exclusively by the kidneys?
What is the primary mechanism by which drugs are eliminated from the body when they are being eliminated exclusively by the kidneys?
Which process involves the removal of drug molecules from the blood by the kidney?
Which process involves the removal of drug molecules from the blood by the kidney?
What is the term for the volume of serum or blood completely cleared of drug per unit time?
What is the term for the volume of serum or blood completely cleared of drug per unit time?
Which parameter is defined as the fraction of drug that is removed from the blood as it crosses an eliminating organ?
Which parameter is defined as the fraction of drug that is removed from the blood as it crosses an eliminating organ?
What does renal clearance measure specifically?
What does renal clearance measure specifically?
Which equation defines the rate of renal excretion based on renal clearance and drug plasma concentration?
Which equation defines the rate of renal excretion based on renal clearance and drug plasma concentration?
Which mechanism involves the physical movement of a drug from the kidney tubules back to the blood?
Which mechanism involves the physical movement of a drug from the kidney tubules back to the blood?
What is the normal range of creatinine clearance for adult males?
What is the normal range of creatinine clearance for adult males?
What is the normal range of serum creatinine concentration for adult women?
What is the normal range of serum creatinine concentration for adult women?
Which statement regarding creatinine clearance is true?
Which statement regarding creatinine clearance is true?
If a drug's normal dose is 250 mg four times a day, how can the dose be adjusted for a patient with reduced creatinine clearance?
If a drug's normal dose is 250 mg four times a day, how can the dose be adjusted for a patient with reduced creatinine clearance?
Which of the following processes is involved in creatinine clearance?
Which of the following processes is involved in creatinine clearance?
What is the significance of creatinine clearance in the context of drug dosing?
What is the significance of creatinine clearance in the context of drug dosing?
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