Drug Distribution in Lecture 3
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Questions and Answers

Which factor affects the distribution of drugs across the blood-brain barrier?

  • Lipid and water solubility (correct)
  • pH of maternal and fetal blood
  • Plasma protein duration of action
  • Plasma protein binding

    • Which drug can penetrate the blood-brain barrier rapidly to produce general anesthesia?

  • Tetracycline
  • Dopamine
  • Barbital
  • Thiopental (correct)

    • What is the main plasma protein involved in drug binding with acidic drugs?

  • Dicoumarol
  • Albumin (correct)
  • Thiopental
  • Globulin

    • Why can't dopamine be used as a replacement therapy for Parkinsonism?

    <p>It is water-soluble and cannot penetrate the blood-brain barrier</p> Signup and view all the answers

    Which factor affects placental distribution of drugs?

    <p>Lipid and water solubility</p> Signup and view all the answers

    Which of the following is NOT a physiological barrier to drug distribution?

    <p>Tumor cell membrane barrier</p> Signup and view all the answers

    What is the distribution equilibrium of mepacrine in the liver compared to plasma?

    <p>21,000/1</p> Signup and view all the answers

    What factor affects the cellular distribution of drugs according to the pH-partition theory?

    <p>Size of molecules</p> Signup and view all the answers

    Which type of tissue is classified as poorly perfused in drug distribution?

    <p>Skeleton</p> Signup and view all the answers

    In what condition is the cellular distribution of phenobarbital enhanced?

    <p>Acidosis</p> Signup and view all the answers

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