10 Questions
Which factor affects the distribution of drugs across the blood-brain barrier?
Lipid and water solubility
Which drug can penetrate the blood-brain barrier rapidly to produce general anesthesia?
Thiopental
What is the main plasma protein involved in drug binding with acidic drugs?
Albumin
Why can't dopamine be used as a replacement therapy for Parkinsonism?
It is water-soluble and cannot penetrate the blood-brain barrier
Which factor affects placental distribution of drugs?
Lipid and water solubility
Which of the following is NOT a physiological barrier to drug distribution?
Tumor cell membrane barrier
What is the distribution equilibrium of mepacrine in the liver compared to plasma?
21,000/1
What factor affects the cellular distribution of drugs according to the pH-partition theory?
Size of molecules
Which type of tissue is classified as poorly perfused in drug distribution?
Skeleton
In what condition is the cellular distribution of phenobarbital enhanced?
Acidosis
Understand the concept of drug distribution and the reversible transfer of drugs between blood and extravascular fluids and tissues. Explore the distribution equilibrium of mepacrine in different organs and plasma.
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