20 Questions
Which class of drugs in the Biopharmaceutics Classification System has significant problems for oral drug delivery?
Class IV
Which BCS class is defined as not being soluble in ≤ 250 mL of aqueous media over the range pH1 – pH7.5?
Class II
Which drug is an example of a Class III drug in the Biopharmaceutics Classification System?
Atenolol
Which drug is an example of a Class IV drug in the Biopharmaceutics Classification System?
Hydrochlorothiazide
Which of the following drugs is classified as poorly soluble according to the Biopharmaceutics Classification System?
Carbamazepine
Which drug had its oral bioavailability (BA) studied in rats using a solution and suspension in sesame oil?
Steroid
Which drug had its lipophilic prodrugs studied in rats, with a solution in short chain fatty acid resulting in 4-fold greater BA than a solution of phenytoin sodium?
Phenytoin
Which drug had its oral BA studied in beagle dogs using an oleic acid solution, resulting in 1-fold greater BA than a standard capsule?
Antimalarial amine
Which drug had its oral BA studied in beagle dogs using an oleic acid solution, resulting in 4-fold greater BA than a standard tablet?
Cinnarizine
What are lipid nanoparticles, and how are they prepared?
Particles prepared by high pressure homogenization techniques, solvent emulsification-evaporation, and sonoprocessing.
What is the BCS classification for drugs with high solubility but low permeability?
Class I
Which drug would most likely be classified as a Class II drug based on its characteristics?
Diclofenac
In the BCS, drugs that are poorly soluble are defined as not being soluble in how much aqueous media?
≤ 250 mL
Which therapeutic area would most likely have a higher percentage of new drugs classified as poorly soluble?
Oncology
Which drug from the list is an example of a Class IV drug according to the Biopharmaceutics Classification System?
Furosemide
Which drug's bioavailability was found to be 3-fold greater from a lipid solution in sesame oil compared to an aqueous suspension?
Steroid
In which study was the bioavailability found to be 4-fold greater from a solution in short chain fatty acid compared to a solution of phenytoin sodium?
Phenytoin lipophilic prodrugs study in rats
Which drug had its bioavailability studied in rats using both a solution and suspension in sesame oil?
Steroid
Which drug had its bioavailability found to be 1-fold greater from an oleic acid solution compared to a standard capsule in a study with beagle dogs?
Antimalarial amine
Which drug had its bioavailability found to be 4-fold greater from an oleic acid solution compared to a standard tablet in a study with beagle dogs?
Cinnarizine
Explore advanced topics in drug delivery including BCS classification, dissolution models, and formulation methods for enhancing solubility and dissolution rates. Learn about the relationships between drug solubility, permeability, and absorption for different drug classes.
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