Drug Delivery Exam

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Questions and Answers

What is the primary consideration for designing a fast acting anti-inflammatory system?

Optimizing the Log P values of the dexamethasone prodrugs

Accumulating the nanoparticles in inflamed tissues (correct)

Minimizing the molecular weight of the polymer constituent

Maximizing the circulation time of the nanoparticles in the bloodstream

How would increasing the molecular weight of the polymer affect the polymer chain packing dynamics?

It would increase the polymer chain packing density, leading to slower drug release (correct)

It would have no effect on the polymer chain packing dynamics

It would decrease the polymer chain packing density

It would increase the polymer degradation rate

What is the primary advantage of using dexamethasone prodrugs in the design of the drug delivery systems?

They can be chemically functionalized to improve performance (correct)

They have improved bioavailability compared to dexamethasone

They have a longer circulation time in the bloodstream

They have a faster release rate compared to dexamethasone

What is the main challenge associated with designing a slow acting anti-inflammatory system?

Optimizing the polymer degradation rate to achieve slow release Signup and view all the answers

What is the role of Log P values in the design of the drug delivery systems?

They determine the lipophilicity of the dexamethasone prodrugs Signup and view all the answers

What is the size range of the polymeric nanoparticles that can be used in the design of the drug delivery systems?

50-500 nm Signup and view all the answers

What is the primary function of doxorubicin in cancer treatment?

Intercalating with DNA to prevent cell replication Signup and view all the answers

What is the purpose of designing a slow acting and long circulating system for intravenous injection of doxorubicin?

To prolong the therapeutic effect of the drug Signup and view all the answers

What is the range of liposome sizes that can be used for doxorubicin delivery?

50-300 nm Signup and view all the answers

What is the mechanism of action of dexamethasone in treating inflammation?

Binding to glucocorticoid receptors to suppress the inflammatory response Signup and view all the answers

What is the primary advantage of using liposomes as a nanocarrier system for doxorubicin delivery?

Targeted delivery of the drug to the tumor site Signup and view all the answers

What is the purpose of chemically functionalizing the liposome system?

To enhance the targeting of the liposome system to specific cells Signup and view all the answers

What is the primary challenge associated with the design of a fast acting system for intratumoral injection of doxorubicin?

Achieving rapid release of the drug from the liposome system Signup and view all the answers

What is the role of glucocorticoid receptors in the mechanism of action of dexamethasone?

They are involved in the suppression of the inflammatory response Signup and view all the answers

Study Notes

Drug Delivery Systems

Doxorubicin is an intercalating agent used as a chemotherapeutic, available in non-salt or hydrochloride salt form.
Log D profile of doxorubicin is important for designing drug delivery systems.

Liposome-Based Drug Delivery Systems for Doxorubicin

Fast-acting system for intratumoral injection:
- Liposomes with 50-300 nm size range
- Fundamental science: liposome stability mechanisms, physicochemical properties, and biological interactions
- System design: rapid release, intratumoral injection
Slow-acting system for intravenous injection:
- Liposomes with 50-300 nm size range
- Fundamental science: liposome stability mechanisms, physicochemical properties, and biological interactions
- System design: slow release, long circulation, intravenous injection

Dexamethasone and Prodrugs

Dexamethasone is a corticosteroid that binds to glucocorticoid receptors, suppressing inflammatory responses.
Log P values at physiological pH for dexamethasone and prodrugs (dexamethasone 21-hemisuccinate and dexamethasone 21-palmitate) are important for designing drug delivery systems.

Polymeric Nanoparticle-Based Drug Delivery Systems for Dexamethasone

Fast-acting system for inflamed tissues:
- Polymeric nanoparticles with 50-500 nm size range
- Fundamental science: molecular weight of polymer, chain packing dynamics, and degradation
- System design: rapid release, accumulation in inflamed tissues
Slow-acting system for prolonged circulation:
- Polymeric nanoparticles with 50-500 nm size range
- Fundamental science: molecular weight of polymer, chain packing dynamics, and degradation
- System design: slow release, long duration, circulating in the bloodstream

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Description

This is a 2-hour written exam for the Drug Delivery course at the Technical University of Denmark. It consists of 2 questions, each worth 50 points. Students can use all aids allowed.