Polymeric Prodrugs and Drug Delivery Systems

Polymers serve as carriers for the delivery of drugs, proteins, targeting moieties, and imaging agents.

Polymeric prodrugs increase water solubility and enhance drug bioavailability.

Polymeric prodrugs enhance pharmacokinetics by prolonging circulation time and protecting drugs from deactivation.

<p>Polymer conjugates can have either 'tuned' degradable bonds or non-degradable bonds.</p> Signup and view all the answers

<p>Reduced antigenic activity leads to a less pronounced immunological response, improving the drug's safety profile.</p> Signup and view all the answers

<p>Lower aqueous solubility is a property that makes drug molecules suitable for polymeric conjugate formation.</p> Signup and view all the answers

<p>An example is PEG-Adenosine deaminase.</p> Signup and view all the answers

<p>Polymeric prodrugs can provide passive or active targeting mechanisms to deliver drugs specifically to their sites of action.</p> Signup and view all the answers

<p>Biopolymers are polymers produced by living organisms, and examples include cellulose and proteins.</p> Signup and view all the answers

<p>Polymers aid in forming advanced drug delivery systems that may include multiple active components enhancing the main drug's activity.</p> Signup and view all the answers

<p>Increased plasma stability and reduced protein immunogenicity.</p> Signup and view all the answers

<p>Chemical structure and steric hindrance.</p> Signup and view all the answers

<p>It complicates the selective conjugation process.</p> Signup and view all the answers

<p>Dicyclohexyl carbodiimide (DCC).</p> Signup and view all the answers

<p>Covalent bonds such as ester or amide bonds.</p> Signup and view all the answers

<p>They target cancerous tissues while reducing peripheral side effects.</p> Signup and view all the answers

<p>It facilitates the release of the parent drug in situ.</p> Signup and view all the answers

<p>Prodrugs that are broken down inside cells to release active substances.</p> Signup and view all the answers

<p>A DDS targets specific organs or cells and releases specified drug amounts at designated times.</p> Signup and view all the answers

<p>They form an active drug.</p> Signup and view all the answers

<p>A targeting moiety, a carrier, and one or more active components.</p> Signup and view all the answers

<p>Reactive functional groups in the polymer and functional groups on the biological component.</p> Signup and view all the answers

<p>The spacer arm controls the site and rate of active drug release through hydrolysis or enzymatic degradation.</p> Signup and view all the answers

<p>Chemical nature, biodegradability, origin, and molecular weight.</p> Signup and view all the answers

<p>To facilitate visualization and tracking of the prodrug within biological systems.</p> Signup and view all the answers

<p>They ensure compatibility with biological tissues, reducing immune reactions and enhancing drug delivery efficiency.</p> Signup and view all the answers

<p>It serves as a highly reactive agent for amine coupling reactions at physiological pH.</p> Signup and view all the answers

<p>By using cell-specific or non-specific uptake enhancers.</p> Signup and view all the answers

<p>Ligands, peptides, proteins, carbohydrates, lipids, polymers, nucleic acids, and oligonucleotides.</p> Signup and view all the answers

A molecule composed of repeating units called monomers.

Polymers produced by living organisms.

A drug molecule chemically linked to a polymer carrier.

A type of polymer used as a carrier for drug delivery, known for its non-toxic nature.

A key advantage of polymeric prodrugs, improving how much of the drug reaches its target.

A benefit of polymeric prodrugs where the drug is shielded from breakdown in the body.

Polymeric prodrugs can be designed to target specific organs or tissues.

Polymeric prodrugs can improve how quickly a drug enters and leaves the body.

Polymeric prodrugs can make drugs less likely to trigger an immune response.

Polymeric prodrugs can incorporate additional components to further enhance the drug's effectiveness.

A part of a polymeric prodrug that helps control the release of the drug from the polymer.

The portion of a polymeric prodrug that allows the carrier to specifically target a particular site in the body.

A component of a polymeric prodrug that can be used for imaging, allowing doctors to track the drug's movement in the body.

The backbone of a polymeric prodrug, providing a carrier for the drug and potentially other components.

A chemical reaction involving the formation of a conjugate between a polymer and a bioactive molecule.

A type of chemical coupling method often used for bioconjugation, especially suitable for attaching molecules with amine groups.

A method of designing polymeric prodrugs that ensure the drug is released at a specific location in the body.

A type of polymer commonly used to modify protein drugs, increasing their stability in the bloodstream and reducing their likelihood of triggering an immune response.

Adding a polymer, like PEG, to a drug molecule can improve how well the drug enters and leaves the body, influencing its effectiveness.

The chemical structure, molecular weight, steric hindrance (how much space it takes up), and the reactivity of both the drug and the polymer all play crucial roles in determining how well they combine.

Connecting a drug to a polymer can shield it from breakdown processes in the body, allowing it to remain active for a longer period.

Polymer conjugation can be used to improve the balance between the drug's effectiveness and its potential harmful side effects.

Polymeric prodrugs are often designed to break down inside specific cells, releasing the active drug only at the target site.

By carefully controlling the structure of the polymer, scientists can design prodrugs that target particular tissues or organs in the body.

Covalent bonds, like ester or amide, are very strong and can keep the drug attached to the polymer, ensuring targeted delivery.

Some polymeric prodrugs are designed to release the drug in response to specific environmental conditions, like changes in pH or enzyme activity, found in particular areas of the body.

The process of creating a conjugate involves specific steps to ensure that the drug and the polymer connect properly.