Drug Delivery and Targeting Quiz

Drug Delivery and Targeting Approaches

• Drug delivery and targeting aim to deliver drugs to their precise site of action at the right concentration and time.
• The drug needs to be pharmacologically active and arrive at the right place and time to exert its pharmaceutical effect.
• In cancer, there are minimal differences between cancer and non-cancer cells, while bacterial and mammalian cells have significant differences.
• Paul Ehrlich introduced the concept of finding a selective target, also known as the magic bullet.
• Drug targeting aims to localize and concentrate drugs to the desired therapeutic site while avoiding side effects.
• First-order targeting involves targeting an organ or tissue, second-order targeting targets a certain type of cells, and third-order targeting targets intracellular compartments.
• Conventional dosage forms rely on the physicochemical properties of the active ingredient, while non-conventional dosage forms rely on the technological characteristics of the formulation.
• Slow drug release leads to modified release formulations.
• Different drug delivery approaches include monoclonal antibodies, prodrugs, and macromolecular carriers.
• Monoclonal antibodies are potent and selective active pharmaceutical ingredients that bind to antigens.
• Prodrugs are chemically and pharmacologically inactive derivatives of the drug that are activated at the site of action.
• Macromolecular carriers transport the drug to the desired site of action and ensure selectivity, with carriers being either particulate or soluble.