Podcast
Questions and Answers
Which form of a drug crosses membranes?
Which form of a drug crosses membranes?
- Polymerized form
- Non-ionized form (correct)
- Hydrogenated form
- Ionized form
What is the effect of pH on drug absorption?
What is the effect of pH on drug absorption?
- It determines whether the drug is ionized or non-ionized (correct)
- It only affects water solubility
- It influences the vascularity of the drug
- It changes the surface area available for absorption
In what equilibrium do weak acids or weak bases exist?
In what equilibrium do weak acids or weak bases exist?
- Non-ionized or unionized forms (correct)
- Non-polar forms
- Only ionized forms
- Fully charged forms
Which form of a drug is better renally excreted?
Which form of a drug is better renally excreted?
What happens to ionized forms of drugs in the filtrate?
What happens to ionized forms of drugs in the filtrate?
Why is lactulose useful in hepatic encephalopathy?
Why is lactulose useful in hepatic encephalopathy?
What term is used to describe the action of the body on drugs?
What term is used to describe the action of the body on drugs?
Which factor primarily determines the route(s) of drug administration?
Which factor primarily determines the route(s) of drug administration?
What is the main characteristic of a drug according to the text?
What is the main characteristic of a drug according to the text?
What does Vol. of distribution refer to in pharmacokinetics?
What does Vol. of distribution refer to in pharmacokinetics?
Which process involves the breakdown of drugs into metabolites?
Which process involves the breakdown of drugs into metabolites?
What is the purpose of understanding pharmacokinetics in medication administration?
What is the purpose of understanding pharmacokinetics in medication administration?
What is the main factor affecting the calculation of apparent volume of distribution (Vd)?
What is the main factor affecting the calculation of apparent volume of distribution (Vd)?
How does a high Vd value compare to a low Vd value?
How does a high Vd value compare to a low Vd value?
What is the significance of knowing the apparent volume of distribution (Vd) in the clinical setting?
What is the significance of knowing the apparent volume of distribution (Vd) in the clinical setting?
Which barrier limits the passage of only lipid-soluble drugs or those transported by facilitated diffusion to reach the brain?
Which barrier limits the passage of only lipid-soluble drugs or those transported by facilitated diffusion to reach the brain?
What factor influences the duration of action of CNS drugs more than the half-life after an initial dose?
What factor influences the duration of action of CNS drugs more than the half-life after an initial dose?
How does the blood/fat ratio influence the rate of redistribution and duration of action for a second dose of a drug?
How does the blood/fat ratio influence the rate of redistribution and duration of action for a second dose of a drug?
What is the process of distribution of a drug from the systemic circulation to organs and tissue?
What is the process of distribution of a drug from the systemic circulation to organs and tissue?
Which factor may increase the 'free fraction' of a drug in the body, potentially enhancing its effects?
Which factor may increase the 'free fraction' of a drug in the body, potentially enhancing its effects?
What is the term for the equilibrium between bound and free drug molecules in plasma?
What is the term for the equilibrium between bound and free drug molecules in plasma?
Which type of drugs are prone to drug interactions due to their high plasma protein binding and narrow therapeutic range?
Which type of drugs are prone to drug interactions due to their high plasma protein binding and narrow therapeutic range?
What is the area under the curve (AUC) that represents the horizontally striped area known as?
What is the area under the curve (AUC) that represents the horizontally striped area known as?
With oral drug administration, where do drugs get absorbed initially?
With oral drug administration, where do drugs get absorbed initially?
What type of reaction involves the addition of a water molecule with subsequent bond breakage?
What type of reaction involves the addition of a water molecule with subsequent bond breakage?
Which genetic polymorphism is associated with local anesthetics and succinylcholine?
Which genetic polymorphism is associated with local anesthetics and succinylcholine?
Monoamine oxidases are involved in the metabolism of which neurotransmitters?
Monoamine oxidases are involved in the metabolism of which neurotransmitters?
Alcohols are metabolized to aldehydes and then to acids by which enzymes?
Alcohols are metabolized to aldehydes and then to acids by which enzymes?
Which phase of biotransformation involves conjugation with endogenous compounds?
Which phase of biotransformation involves conjugation with endogenous compounds?
Depletion of which compound in the liver is associated with acetaminophen hepatotoxicity?
Depletion of which compound in the liver is associated with acetaminophen hepatotoxicity?
