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Questions and Answers
What is the traditional definition of absorption in pharmacokinetics?
What is the traditional definition of absorption in pharmacokinetics?
What is the focus of this module primarily on?
What is the focus of this module primarily on?
How can variability in drug absorption be minimized?
How can variability in drug absorption be minimized?
What is the traditional site where absorption occurs according to the new definition presented?
What is the traditional site where absorption occurs according to the new definition presented?
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Where does drug absorption occur, according to the new definition presented?
Where does drug absorption occur, according to the new definition presented?
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What factors influence drug absorption from the gastrointestinal tract?
What factors influence drug absorption from the gastrointestinal tract?
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What factors influence drug absorption from the gastrointestinal tract?
What factors influence drug absorption from the gastrointestinal tract?
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What does extravascular drug delivery depend on?
What does extravascular drug delivery depend on?
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How can variability in drug absorption be minimized?
How can variability in drug absorption be minimized?
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What does this module primarily focus on?
What does this module primarily focus on?
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What is the traditional site where absorption occurs according to the new definition presented?
What is the traditional site where absorption occurs according to the new definition presented?
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What does extravascular drug delivery depend on?
What does extravascular drug delivery depend on?
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How can variability in drug absorption be minimized?
How can variability in drug absorption be minimized?
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What is the focus of this module primarily on?
What is the focus of this module primarily on?
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What factors influence drug absorption from the gastrointestinal tract?
What factors influence drug absorption from the gastrointestinal tract?
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Study Notes
Definition of Absorption
- Traditional definition of absorption in pharmacokinetics: the process by which a drug enters the bloodstream
- New definition of absorption: the process by which a drug becomes available for distribution and elimination
Focus of the Module
- The module primarily focuses on the absorption of drugs
Minimizing Variability in Drug Absorption
- Variability in drug absorption can be minimized by controlling the rate of drug release from the dosage form and the rate of gastric emptying
Sites of Absorption
- Traditional site of absorption: the gastrointestinal tract
- New definition of absorption: absorption can occur at any site, including the skin, lungs, and mucous membranes
Factors Influencing Drug Absorption
- Factors that influence drug absorption from the gastrointestinal tract:
- Physiochemical properties of the drug (e.g. solubility, permeability)
- Formulation of the dosage form (e.g. tablet, capsule, solution)
- Presence of food and its composition
- Gastric pH and emptying rate
- Gut wall metabolism and transport
Extravascular Drug Delivery
- Extravascular drug delivery depends on the rate of drug absorption from the site of administration (e.g. skin, lungs, mucous membranes)
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Description
Study the kinetics of drug absorption and understand the process of drug reaching the systemic circulation or crossing the apical membrane of enterocytes lining the intestine.
