Lecture 3
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Questions and Answers

Which process is responsible for transmitting a chemical or physical signal through a cell?

  • Pharmacologic effect generation
  • Signal Transduction Mechanism (correct)
  • Drug Schedules Defined
  • Common abbreviation on drug administration

    • What is the ultimate outcome of the transmembrane signaling process?

  • Recognition and binding of an extracellular signal
  • Pharmacologic effect initiation
  • Generation of intracellular signal by effector protein (correct)
  • Ligand binding

    • What is the role of ligand binding in the signal transduction process?

  • Generation of intracellular signal by effector protein
  • Recognition and binding of an extracellular signal
  • Initiation of the process (correct)
  • Pharmacologic effect initiation

    • What is the function of an integral membrane receptor protein in transmembrane signaling?

    <p>Recognition and binding of an extracellular signal</p> Signup and view all the answers

    What is the first step in the process of transmembrane signaling?

    <p>Recognition and binding of an extracellular signal</p> Signup and view all the answers

    What does the term 'signal transduction' refer to?

    <p>Transmitting a chemical or physical signal through a cell</p> Signup and view all the answers

    What initiates the process of signal transduction?

    <p>Ligand binding</p> Signup and view all the answers

    Which of the following is NOT a mechanism for signal transduction?

    <p>Receptor dynamics like desensitization and tachyphylaxis</p> Signup and view all the answers

    Which of the following is an example of intracellular receptors?

    <p>Transcription factors for steroid hormones</p> Signup and view all the answers

    What type of receptors are GABA receptors?

    <p>Membrane-spanning receptors linked to ion channels</p> Signup and view all the answers

    Which of the following is a common abbreviation in drug administration?

    <p>PRN (As needed)</p> Signup and view all the answers

    What should be done if a family member forgets their asthma inhaler during a visit?

    <p>Offer them the physician's own inhaler or help them obtain a new prescription</p> Signup and view all the answers

    When should a lost prescription pad be reported?

    <p>To the medical board or the police</p> Signup and view all the answers

    What are second messenger signaling cascades involved in?

    <p>Conveying extracellular signals across the plasma membrane</p> Signup and view all the answers

    What is an example of a membrane-spanning receptor?

    <p>Receptor linked to ion channels and activators of second messenger signaling</p> Signup and view all the answers

    What is an example of a common abbreviation in drug administration?

    <p>BID (twice a day)</p> Signup and view all the answers

    What should be done if a lost prescription pad is found?

    <p>Report it to the medical board or the police</p> Signup and view all the answers

    What type of enzymes are involved in intracellular receptors?

    <p>Enzymes like cyclooxygenase for NSAIDs</p> Signup and view all the answers

    Which process involves the recognition and binding of an extracellular signal by an integral membrane receptor protein and generation of intracellular signal by one or more effector protein?

    <p>Signal Transduction Mechanism</p> Signup and view all the answers

    What does the term 'transmembrane signaling processes' refer to?

    <p>Recognition and Binding of Extracellular Signal</p> Signup and view all the answers

    What is the function of an integral membrane receptor protein in transmembrane signaling?

    <p>Recognition and Binding of Extracellular Signal</p> Signup and view all the answers

    What initiates the process of signal transduction?

    <p>Ligand Binding</p> Signup and view all the answers

    Which of the following is an example of a receptor linked to ion channels?

    <p>GABA receptors</p> Signup and view all the answers

    What is the role of receptor tyrosine kinases in signal transduction?

    <p>Ligand-regulated enzyme receptors</p> Signup and view all the answers

    Which process is responsible for desensitization, tachyphylaxis, tolerance, and sensitization?

    <p>Receptor dynamics</p> Signup and view all the answers

    What should be done if a lost prescription pad is found?

    <p>Report it to the medical board or the police</p> Signup and view all the answers

    When should a family member forgets their asthma inhaler during a visit, what should the physician do?

    <p>Offer them their own inhaler or help them obtain a new prescription</p> Signup and view all the answers

    Which of the following is NOT a mechanism for signal transduction?

    <p>Receptor tyrosine kinases activating second messenger signaling cascades</p> Signup and view all the answers

    What type of receptors are G-proteins?

    <p>Ligand-regulated enzyme receptors</p> Signup and view all the answers

    What does the term 'signal transduction' refer to?

    <p>The process of conveying intracellular signals across the plasma membrane</p> Signup and view all the answers

    What is an example of a common abbreviation in drug administration?

    <p>PRN (as needed)</p> Signup and view all the answers

    What are second messenger signaling cascades involved in?

    <p>Intracellular responses</p> Signup and view all the answers

    What is the function of an integral membrane receptor protein in transmembrane signaling?

    <p>Linking to effector enzymes for intracellular responses</p> Signup and view all the answers

    Which of the following is an example of intracellular receptors?

    <p>Structural proteins like colchicine for microtubules</p> Signup and view all the answers

    Study Notes

    • Signal transduction is the process by which extracellular signals are conveyed across the plasma membrane and elicit intracellular responses.

    • Signal transduction can occur through various mechanisms such as:

      • Lipid-soluble chemicals binding to intracellular receptors
      • Drug binding to extracellular domains of transmembrane proteins
      • Signal binding to cell-surface receptors linked to effector enzymes
      • Direct binding of signals to ion channels

    • Intracellular receptors include various types:

      • Transcription factors, such as those for steroid hormones
      • Enzymes, like cyclooxygenase for NSAIDs
      • Structural proteins, such as colchicine for microtubules
      • Nucleic acids, like DNA for anticancer drugs
      • Signal transduction molecules, such as mTOR for anticancer drugs

    • Membrane-spanning receptors include those linked to ion channels and activators of second messenger signaling

    • Receptor tyrosine kinases are a type of ligand-regulated enzyme receptors

    • G-proteins couple receptors to various effects

    • GABA receptors are examples of receptors linked to ion channels

    • Second messenger signaling cascades involve various proteins and pathways

    • Receptor dynamics include desensitization, tachyphylaxis, tolerance, and sensitization

    • Common abbreviations in drug administration include: BID (twice a day), TID (three times a day), QID (four times a day), and PRN (as needed)

    • A lost prescription pad should be reported to the medical board or the police.

    • When a family member forgets their asthma inhaler during a visit, the physician should offer them their own inhaler or help them obtain a new prescription.

    • The physician should not ask the patient to meet them at Starbucks to return the prescription pad, or confront them at their address without proper authorization.

    • Signal transduction is the process by which extracellular signals are conveyed across the plasma membrane and elicit intracellular responses.

    • Signal transduction can occur through various mechanisms such as:

      • Lipid-soluble chemicals binding to intracellular receptors
      • Drug binding to extracellular domains of transmembrane proteins
      • Signal binding to cell-surface receptors linked to effector enzymes
      • Direct binding of signals to ion channels

    • Intracellular receptors include various types:

      • Transcription factors, such as those for steroid hormones
      • Enzymes, like cyclooxygenase for NSAIDs
      • Structural proteins, such as colchicine for microtubules
      • Nucleic acids, like DNA for anticancer drugs
      • Signal transduction molecules, such as mTOR for anticancer drugs

    • Membrane-spanning receptors include those linked to ion channels and activators of second messenger signaling

    • Receptor tyrosine kinases are a type of ligand-regulated enzyme receptors

    • G-proteins couple receptors to various effects

    • GABA receptors are examples of receptors linked to ion channels

    • Second messenger signaling cascades involve various proteins and pathways

    • Receptor dynamics include desensitization, tachyphylaxis, tolerance, and sensitization

    • Common abbreviations in drug administration include: BID (twice a day), TID (three times a day), QID (four times a day), and PRN (as needed)

    • A lost prescription pad should be reported to the medical board or the police.

    • When a family member forgets their asthma inhaler during a visit, the physician should offer them their own inhaler or help them obtain a new prescription.

    • The physician should not ask the patient to meet them at Starbucks to return the prescription pad, or confront them at their address without proper authorization.

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    Description

    Test your knowledge of Dose Response Receptor Theory 2 with this quiz. Topics include signal transduction mechanism and drug effects on receptors. Perfect for first year M1 students.

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