Donepezil Drug Interactions Quiz
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Questions and Answers

What is the primary interaction between donepezil and anticholinergic drugs?

  • Donepezil increases the bioavailability of anticholinergics.
  • Donepezil and anticholinergics do not interact with each other.
  • Donepezil antagonizes the activity of anticholinergics. (correct)
  • Donepezil and anticholinergics have a synergistic cholinergic effect.
  • Which of the following is the recommended action if bethanechol and donepezil must be given concurrently?

  • Increase the dose of bethanechol.
  • Increase the dose of donepezil.
  • Decrease the dose of bethanechol. (correct)
  • No dose adjustments are necessary.
  • How does donepezil affect the pharmacokinetics of furosemide, digoxin, and warfarin?

  • Donepezil increases the bioavailability of these drugs.
  • Donepezil decreases the binding of these drugs.
  • Donepezil increases the binding of these drugs.
  • Donepezil does not affect the binding of these drugs. (correct)
  • What is the recommended action when donepezil is co-administered with CYP2D6 and 3A4 inducers?

    <p>Avoid concurrent administration.</p> Signup and view all the answers

    How does cimetidine affect the pharmacokinetics of galantamine?

    <p>Cimetidine increases the bioavailability of galantamine by 16%.</p> Signup and view all the answers

    What is the recommended action when memantine is co-administered with drugs that make the urine alkaline?

    <p>Avoid concurrent administration or monitor for increased drug effects.</p> Signup and view all the answers

    Which of the following drugs should be avoided when using neostigmine or pyridostigmine?

    <p>All of the above</p> Signup and view all the answers

    What is the concern with using corticosteroids concurrently with neostigmine or pyridostigmine?

    <p>Corticosteroids decrease the anti-AChE effects of neostigmine or pyridostigmine</p> Signup and view all the answers

    Which of the following statements about magnesium is correct?

    <p>Magnesium has a direct depressant effect on skeletal muscle and may antagonize the beneficial effects of neostigmine or pyridostigmine</p> Signup and view all the answers

    What is the potential concern with using methocarbamol concurrently with pyridostigmine?

    <p>The concern is based on a single case report, and more information is needed</p> Signup and view all the answers

    Which of the following statements about rivastigmine is correct?

    <p>Both B and C</p> Signup and view all the answers

    What is the concern with using local and general anesthetics or antiarrhythmics concurrently with neostigmine?

    <p>These drugs may decrease the effects of neostigmine</p> Signup and view all the answers

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