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What is the primary use of donepezil (Aricept)?
How does donepezil increase acetylcholine levels in the brain?
Where does metabolism of donepezil take place?
What is the peak of action time for donepezil after oral administration?
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How is donepezil excreted from the body?
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What is the primary mechanism of action of donepezil in treating Alzheimer’s disease?
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What is the percentage of plasma protein binding for donepezil?
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Which condition is NOT listed as a potential use of donepezil?
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What is the effect of donepezil on the progression of Alzheimer’s disease according to long-term studies?
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What is the effect of food on the absorption of donepezil after oral administration?
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Which medication is a cholinesterase inhibitor used to treat mild to moderate dementia due to Alzheimer’s and Parkinson’s disease?
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What is the duration of the transdermal form of rivastigmine?
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Where does the metabolism of rivastigmine occur?
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What is the peak action time of memantine?
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How is memantine excreted from the body?
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What is the terminal elimination half-life of memantine?
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What is the main action of memantine in Alzheimer's patients?
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What is a contraindication for memantine use?
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What should be assessed in nursing implications for memantine?
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For what type of patients is the donepezil-memantine combination drug (Namzaric) available?
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What is a common adverse effect of donepezil?
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What is a contraindication to donepezil?
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What should nurses assess for before administering donepezil?
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What is a similarity between donepezil and galantamine hydrobromide?
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Why is careful monitoring of liver function necessary in patients taking donepezil?
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In which patient population is donepezil used to reduce cognitive dysfunction?
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What is a nursing implication for patients with Alzheimer's disease receiving home care?
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What is a recommendation for patient teaching regarding donepezil?
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What is a medication interaction concern with donepezil?
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What is a nursing caution related to the administration of donepezil?
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Study Notes
Donepezil Dosage and Nursing Implications
- Older adults are more susceptible to adverse drug effects due to age-related changes and underlying conditions.
- Liver disease can affect the metabolism of donepezil, leading to increased adverse effects, necessitating careful monitoring of liver function and medication response.
- Donepezil is used in critical illness to reduce cognitive dysfunction, especially in patients with delirium, a form of acute cognitive dysfunction common in critically ill patients.
- Patients with Alzheimer's disease receiving home care may have difficulty with medication adherence, necessitating collaboration with responsible family members to ensure accurate drug administration.
- Common adverse effects of donepezil include headache, dizziness, depression, vertigo, insomnia, nausea, vomiting, diarrhea, abdominal muscle cramps, anorexia, GI bleeding, breathing problems, fainting, heart disease, dyspnea, fatigue, anorexia, seizures, and trouble urinating.
- Contraindications to donepezil include hypersensitivity to the drug and pre-existing lung or heart diseases such as sick sinus syndrome.
- Many medications interact with donepezil, either increasing or decreasing its effects, highlighting the importance of preventing potential drug interactions.
- Before administering donepezil, nurses should assess for allergy, orientation, and contraindications, and administer the medication at bedtime, ensuring proper administration of oral disintegrating tablets.
- Nurses should be cautious with the brand names for donepezil (Aricept) and rabeprazole (AcipHex) to prevent confusion during administration.
- Nursing assessment for therapeutic effects involves monitoring memory improvement and reduction of dementia, while assessment for adverse effects includes GI upset symptoms and potential GI bleeding.
- Patient teaching for donepezil includes guidelines on proper drug administration, expectations regarding the drug's effects, reporting of side effects, and the importance of regular blood tests and follow-up visits.
- Galantamine hydrobromide is a drug similar to donepezil, with indications for mild to moderate dementia and vascular dementia, and patients and families should be instructed to report any changes in mental status and take the medication with food to reduce gastric upset.
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Description
Test your knowledge of donepezil dosage and nursing implications with this quiz. Explore important considerations for administering donepezil to older adults, patients with Alzheimer's disease, and those in critical care. Brush up on nursing assessments, patient teaching, adverse effects, contraindications, and potential drug interactions related to donepezil.
