41 Questions
During which day of gestation in the dog are the optic sulci visible?
Day 13
What happens concurrently with the transformation from optic sulcus to optic vesicle in the dog?
Closure of the neural tube
What is the role of the optic vesicle in the development of the dog's palpebral fissure and orbital structures?
Induction and size determination
Which structure develops from mesenchyme in the optic fissure?
Hyaloid artery
What happens if the optic fissure fails to close normally?
Formation of colobomas
What is the role of the optic vesicle in lens formation?
It induces lens differentiation
What is the initial event leading to the formation of the chambers of the ocular anterior segment?
Lens vesicle detachment
Which structure surrounds the lens vesicle and will become the lens capsule?
Basal lamina
What is the embryonic lens nucleus composed of in the adult?
Primary lens fibers
What continues to develop from the anterior cuboidal epithelial cells in the lens?
Lens cortex
What is the term used for the zonule fibers in the lens?
Tertiary vitreous
Which structure is responsible for promoting primary lens fiber formation in the lens epithelial cells?
The retinal primordium
What is the term used for the central sphere inside the 'Y' sutures in the adult lens?
Lens nucleus
What is the origin of the zonule fibers in the lens?
Embryonic TVL
What could result in congenital ectopia lentis?
Lens coloboma
What is the shape of the lens fibers in the lens?
Hexagonal
What is the term used for the elongation of lens epithelial cells nearest the presumptive retina?
Lens fiber elongation
What is the embryonic lens nucleus composed of in the adult lens?
Lens fibers
What happens if the optic fissure fails to close normally?
Development of lens coloboma
What is the term used for the secondary lens fibers that course anteriorly and posteriorly around the embryonal nucleus?
Y sutures
What is the term used for the localized absence of zonules in the lens?
Lens coloboma
During which day of gestation in the dog do the optic sulci become visible?
Day 13
What is the term used to describe the transformation from optic sulcus to optic vesicle?
Invagination
What contributes to the expansion of the optic vesicle?
Localized proliferation and cell growth
At approximately which day of gestation in the dog can an external bulge indicating the presence of the enlarging optic vesicle be seen?
Day 17
What is the role of the optic vesicle in the development of the palpebral fissure and orbital structures in the dog?
Induction and size determination
What occurs during the invagination of the optic vesicle?
Local apical contraction and physiologic cell death
What structure forms when the surface ectoderm in contact with the optic vesicle thickens?
Lens placode
What happens as the space within the optic vesicle collapses during lens formation?
The invaginating neural ectoderm folds onto itself
What is the embryonic lens nucleus composed of in the adult?
Lens fibers
What surrounds the lens vesicle and will become the lens capsule?
Basal lamina
During which day of gestation in the dog does the hyaloid artery develop from mesenchyme in the optic fissure?
Day 25
What is the consequence of the failure of the optic fissure to close normally?
Formation of colobomas in the iris
What is the protein content in the embryonic vitreous humor derived from?
Plasma proteins entering the eye by diffusion
What is the role of the optic vesicle in lens formation?
It gives the surface ectoderm a lens-forming bias
What is the initial event leading to the formation of the chambers of the ocular anterior segment?
Lens vesicle detachment
What may result from faulty keratolenticular separation?
All of the above
What is the consequence of abnormal orientation of the optic vesicle as it approaches the surface ectoderm?
Formation of a lens vesicle in an abnormal location
What is the size of the lens vesicle determined by?
The contact area of the optic vesicle with the surface ectoderm
What is aplasia a result of in lens development?
Both A and B
What is one of the characteristics of teratogen-induced anterior segment dysgenesis in animal models?
Faulty keratolenticular separation
Test your knowledge on the development of optic sulci and the transformation into optic vesicles in dogs.
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