cancer epigenetics (II)

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how do non-analog DNMT inhibitors work?

they bind to the active site of DNMTs preventing the transfer of methyl groups to DNA leading to the inhibition of the methylation of TSGs

give two examples of FDA approved DNMTis

vidaza and decitabine

how to HDAC inhibitors work

inhibition of HDAC function reverses the transcriptional regression of TSGs

give an example of an FDA-approved HDAC inhibitor

<p>verinostat</p> Signup and view all the answers

how can epi-drugs be used after cancer treatment?

<p>epi-drugs can be used to target cancer stem cells to prevent relapse</p> Signup and view all the answers

how can epigenetics be used in the diagnosis, prognosis and management of cancer?

<ol> <li>hypermethylation of certain genes detected in biological fluids can be used as a biomarker for diagnosis of cancer</li> <li>hypermethylation of TSGs can indicate poor outcomes in certain cancers</li> <li>hypermethylation can be used to differentiate between benign and malignant cancers</li> </ol> Signup and view all the answers