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DNA Synthesis Inhibitors Quiz

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Questions and Answers

How does gemcitabine inhibit DNA synthesis?

By cross-linking DNA strands
By alkylating DNA
By inhibiting DNA synthesis specifically during the S-phase (correct)
By forming intrastrand bonds with DNA bases

Which drug cross-links DNA by forming intrastrand and interstrand covalent bonds?

Cisplatin (correct)
Bleomycin
Doxorubicin
Mitomycin C

What is the mechanism of action of Vinblastine?

Inhibits topoisomerase II
Inhibits mitosis by blocking microtubule assembly (correct)
Inhibits DNA synthesis during the S-phase
Cross-links DNA strands

How does Etoposide affect DNA?

Causes double-stranded DNA breaks by inhibiting topoisomerase II (D) Signup and view all the answers

Which drug inhibits the BRAF gene to prevent tumour proliferation?

Encorafenib (C) Signup and view all the answers

What is the target of Bevacizumab when used as a monoclonal antibody?

Inhibits VEGFR to decrease angiogenesis (B) Signup and view all the answers

How does Pemetrexed inhibit DNA synthesis?

By inhibiting DHFR, TS, and GARFT (C) Signup and view all the answers

How does Mercaptopurine interfere with DNA synthesis?

By inhibiting purine biosynthesis (B) Signup and view all the answers

What is the mechanism of action of Fludarabine and Cladribine in disrupting DNA synthesis?

Becoming incorporated into developing DNA (D) Signup and view all the answers

How does Cytarabine block DNA synthesis?

Preventing thymidine synthesis (A) Signup and view all the answers

What is the impact of Fluorouracil on DNA and RNA synthesis?

Inhibits thymidylate synthetase and incorporates into RNA (D) Signup and view all the answers

What is the primary effect of Thioguanine on DNA synthesis?

Inhibition of purine biosynthesis (A) Signup and view all the answers