DNA Replication: Leading and Lagging Strands
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Questions and Answers

During DNA replication, in which direction does DNA polymerase III elongate DNA strands?

  • 5' to 3' (correct)
  • 3' to 5'
  • 3' to 3'
  • 5' to 5'

Which strand, between the leading and lagging strands, can elongate continuously as the replication fork progresses?

  • Neither strand
  • Lagging strand
  • Leading strand (correct)
  • Both strands

What is the function of DNA ligase during DNA replication?

  • Priming DNA synthesis
  • Join Okazaki fragments (correct)
  • Elongate DNA strands
  • Initiate polynucleotide synthesis

Which statement is true about the synthesis of the lagging strand during DNA replication?

<p>Multiple primer is needed. (C)</p> Signup and view all the answers

What is the initial nucleotide strand used to start DNA synthesis?

<p>RNA primer (C)</p> Signup and view all the answers

Why can DNA polymerases not initiate the synthesis of a polynucleotide chain?

<p>They can only add nucleotides to the 3' end. (A)</p> Signup and view all the answers

What is the main enzyme responsible for adding nucleotides to the 3' end of a growing DNA strand?

<p>DNA polymerase (B)</p> Signup and view all the answers

Which end of the new DNA strand do DNA polymerases add nucleotides to?

<p>3' end (C)</p> Signup and view all the answers

In which direction does DNA polymerase III synthesize the leading strand during replication?

<p>Towards the replication fork (C)</p> Signup and view all the answers

How is the lagging strand synthesized during DNA replication?

<p>As a series of segments called Okazaki fragments (D)</p> Signup and view all the answers

What is the key function of DNA ligase in DNA replication?

<p>Joining Okazaki fragments on the lagging strand (B)</p> Signup and view all the answers

How does the antiparallel structure of the double helix impact DNA replication?

<p>It requires leading and lagging strand synthesis in opposite directions (A)</p> Signup and view all the answers

What is the role of DNA polymerase III on the leading strand during DNA replication?

<p>Adding DNA nucleotides to the 3' end (D)</p> Signup and view all the answers

During lagging strand synthesis, what is the role of DNA ligase?

<p>Bonds Okazaki fragments together (D)</p> Signup and view all the answers

What happens when a thymine dimer distorts the DNA molecule?

<p>A nuclease enzyme cuts the damaged strand and removes the section (B)</p> Signup and view all the answers

What is the main function of DNA polymerase I in DNA replication?

<p>Removing RNA primers and replacing them with DNA nucleotides (A)</p> Signup and view all the answers

When does DNA polymerase III dissociate from the DNA strand during replication?

<p>When reaching an RNA primer on the lagging strand (B)</p> Signup and view all the answers

What is the consequence of replacing the last RNA nucleotide with DNA during lagging strand synthesis?

<p>Leaves the sugarphosphate backbone with a free 3' end (B)</p> Signup and view all the answers

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