Podcast
Questions and Answers
What is the error rate of DNA polymerase without proofreading?
What is the error rate of DNA polymerase without proofreading?
- 1 per 10^3 nucleotides
- 1 per 10^5 nucleotides (correct)
- 1 per 10^9 nucleotides
- 1 per 10^7 nucleotides
What is the function of MutS in Mismatch Repair (MMR)?
What is the function of MutS in Mismatch Repair (MMR)?
- Scan for nicks in recently synthesized strand
- Scan for mismatches in DNA (correct)
- Trigger degradation of the strand
- Synthesize new DNA strand
What is Microsatellite Instability (MIN) indicative of?
What is Microsatellite Instability (MIN) indicative of?
- Germline mutations in DNA repair genes
- Effective Mismatch Repair
- Increased DNA damage
- Defective Mismatch Repair (correct)
What is the result of germline mutations in genes encoding DNA damage repair/signalling molecules?
What is the result of germline mutations in genes encoding DNA damage repair/signalling molecules?
What is the function of Mismatch Repair (MMR) in maintaining genomic stability?
What is the function of Mismatch Repair (MMR) in maintaining genomic stability?
What is the effect of Mismatch Repair (MMR) on DNA biosynthesis?
What is the effect of Mismatch Repair (MMR) on DNA biosynthesis?
What is the main cause of Germline Instability (GI)?
What is the main cause of Germline Instability (GI)?
Which type of genomic instability occurs due to defective Homologous Recombination Repair (HDR) and/or chromosome segregation?
Which type of genomic instability occurs due to defective Homologous Recombination Repair (HDR) and/or chromosome segregation?
What is the role of Mismatch Repair (MMR) in maintaining genomic stability?
What is the role of Mismatch Repair (MMR) in maintaining genomic stability?
Which DNA repair mechanism is responsible for correcting errors at the nucleotide level?
Which DNA repair mechanism is responsible for correcting errors at the nucleotide level?
What is the consequence of defective spindle checkpoint in cells?
What is the consequence of defective spindle checkpoint in cells?
What is the result of Chromothripsis?
What is the result of Chromothripsis?
What is the error rate of DNA polymerases during replication?
What is the error rate of DNA polymerases during replication?
Which proteins are involved in Homology-directed Repair (HDR)?
Which proteins are involved in Homology-directed Repair (HDR)?
What is the result of single nucleotide and dinucleotide deletions in the TGFBR2 gene?
What is the result of single nucleotide and dinucleotide deletions in the TGFBR2 gene?
What is the role of BRCA1 in DNA repair?
What is the role of BRCA1 in DNA repair?
What is the consequence of disturbed origin firing in DNA replication?
What is the consequence of disturbed origin firing in DNA replication?
What is the function of the MRN complex in DNA repair?
What is the function of the MRN complex in DNA repair?
What is the result of inherited BRCA1 and BRCA2 mutations?
What is the result of inherited BRCA1 and BRCA2 mutations?
What is the purpose of the spindle checkpoint during mitosis?
What is the purpose of the spindle checkpoint during mitosis?
What is the consequence of Mismatch Repair (MMR) deficiency?
What is the consequence of Mismatch Repair (MMR) deficiency?
What is the role of ATM in the DNA damage response?
What is the role of ATM in the DNA damage response?
