DNA Replication and Proofreading

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Questions and Answers

Which enzyme is responsible for removing the RNA primer during eukaryotic DNA replication?

  • DNA Polymerase α
  • DNA Polymerase ε
  • FEN1 (correct)
  • DNA Polymerase δ

What is the function of telomeres in eukaryotic chromosomes?

  • To repair DNA damage
  • To protect the ends of chromosomes (correct)
  • To facilitate DNA replication
  • To remove introns during mRNA splicing

What triggers cellular senescence in eukaryotic cells?

  • Activation of oncogenes
  • Exposure to mutagens
  • Extensive telomere shortening (correct)
  • DNA replication errors

Which enzyme is responsible for adding telomeric repeats to the ends of chromosomes?

<p>Telomerase (C)</p> Signup and view all the answers

Which direction do DNA and RNA polymerases synthesize their nucleic acids in?

<p>5' to 3' (B)</p> Signup and view all the answers

Which type of polymerase requires a pre-existing 3'-OH to begin synthesis?

<p>DNA polymerase (C)</p> Signup and view all the answers

Which strand of the parent molecule becomes the leading strand during DNA synthesis?

<p>The template strand (B)</p> Signup and view all the answers

What is the function of DNA ligase during DNA replication?

<p>To create phosphodiester bonds at 'nicks' (A)</p> Signup and view all the answers

Which enzyme is responsible for unwinding the DNA double helix during replication?

<p>Helicase (D)</p> Signup and view all the answers

Which direction does DNA replication occur?

<p>5' to 3' (B)</p> Signup and view all the answers

Which enzyme is responsible for synthesizing a new DNA strand by adding complementary nucleotides?

<p>DNA polymerase (B)</p> Signup and view all the answers

What is the function of telomerases?

<p>Add telomeres to the ends of chromosomes (A)</p> Signup and view all the answers

Which enzyme separates the strands of dsDNA during DNA replication?

<p>DNA Helicase (A)</p> Signup and view all the answers

Which direction does the leading strand synthesize in relation to the replication fork movement?

<p>5' to 3' in the same direction as fork movement (B)</p> Signup and view all the answers

What is the function of primase in DNA replication?

<p>Synthesizes a short RNA primer (B)</p> Signup and view all the answers

Where can DNA replication begin?

<p>At specific sequences called Origins of Replication (A)</p> Signup and view all the answers

Which enzyme removes incorrect, mispaired nucleotides introduced by DNA polymerase errors?

<p>DNA polymerase I (B)</p> Signup and view all the answers

What is the function of topoisomerases during DNA replication?

<p>They remove positive supercoils (A)</p> Signup and view all the answers

Which type of topoisomerase requires energy from ATP to cut both strands of DNA?

<p>Type II topoisomerase (C)</p> Signup and view all the answers

What is the role of DNA polymerase III in DNA replication?

<p>Closes the final nick between DNA fragments (B)</p> Signup and view all the answers

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Related Documents

OLM-16.1 DNA Replication.pptx

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