DNA Repair Systems and Cancer Association
16 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What type of cancer is associated with mutations in the gene BRCA 1?

  • Skin Cancer
  • Breast and Ovary Cancer (correct)
  • Bladder Cancer
  • Lung Cancer
  • What is a consequence of mutations in DNA repair systems within the body?

  • Enhanced genomic stability
  • Decreased cellular growth
  • Higher likelihood of cancer development (correct)
  • Increased risk of viral infections
  • Which DNA repair system is associated with the gene MDB4?

  • Base Excision Pathway (BER) (correct)
  • Mismatch excision repair (MMR)
  • Non Homologous End Joining
  • Homologous recombination
  • Which cancer is NOT linked to the gene XPC?

    <p>Ovarian Cancer</p> Signup and view all the answers

    Which gene is linked to bladder cancer as a result of DNA repair deficiencies?

    <p>XPC</p> Signup and view all the answers

    Which repair system involves the gene XRCC5?

    <p>Non Homologous End Joining</p> Signup and view all the answers

    Which of the following cancers are associated with MGMT mutations?

    <p>Colorectal and Gastric</p> Signup and view all the answers

    Which process does the term 'direct reversal of damage' refer to?

    <p>Directly correcting DNA damage without the need for excision</p> Signup and view all the answers

    What cancer types are associated with the gene MDB4?

    <p>Colorectal and Ovary</p> Signup and view all the answers

    Which DNA repair system does not have an associated gene listed in the provided information?

    <p>Mismatch Excision Repair (MMR)</p> Signup and view all the answers

    Which gene is linked to breast cancer through its associated repair system?

    <p>BRCA 1</p> Signup and view all the answers

    What role do DNA repair systems play in the body?

    <p>Maintain genomic stability</p> Signup and view all the answers

    Which of the following cancer types is linked to mutations in MGMT?

    <p>Gastric</p> Signup and view all the answers

    Which protein is associated with the Mismatch Excision Repair (MMR) system?

    <p>MLH1</p> Signup and view all the answers

    What is the first cancer listed that is associated with the gene XPC?

    <p>Skin Cancer</p> Signup and view all the answers

    Which DNA repair system is linked with the gene XRCC5?

    <p>Non Homologous End Joining</p> Signup and view all the answers

    Study Notes

    DNA Repair Systems

    • DNA repair systems are crucial for maintaining genomic stability and preventing cancer development.
    • Different repair systems exist, each targeting specific types of DNA damage.
    • Mutations in genes associated with these systems can increase the risk of specific cancer types.

    Base Excision Pathway (BER)

    • MDB4 mutations are linked to colorectal, ovarian, and multiple myeloma cancers.
    • XPC mutations are associated with bladder and skin cancer.

    Direct Reversal of Damage

    • MGMT is involved in the direct reversal of DNA damage.
    • MGMT mutations are linked to colon, gastric, and glioblastoma cancers.

    Non Homologous End Joining

    • XRCC5 mutations are associated with lung cancer.
    • BRCA1 mutations are associated with breast, ovarian, and gastric cancers.

    Mismatch Excision Repair (MMR)

    • MMR is a system dedicated to repairing mismatched bases.
    • Specific genes involved in MMR, like MLH1, MSH2, MSH3, and MSH6, are also associated with various cancer types.

    Homologous Recombination

    • Homologous recombination is a major repair system used for double-strand DNA breaks.
    • Involved in repairing damaged DNA segments using homologous chromosomes as templates.
    • Mutations in genes involved in this process can increase the risk of developing cancer.

    Conclusion

    • The interplay between DNA repair systems, genes, and cancer development is complex.
    • Understanding these relationships is vital for targeted cancer prevention and therapeutic strategies.

    DNA Repair Systems and Cancer Development

    • DNA repair systems play a critical role in maintaining genomic stability and preventing cancer development.
    • Different DNA repair systems target specific types of DNA damage.
    • Mutations in genes involved in DNA repair can increase the risk of developing certain types of cancer.

    Key DNA Repair Systems and Associated Cancers

    • Base Excision Repair (BER): Repairs damaged bases in DNA.
      • MDB4 gene mutations are associated with colorectal, ovarian, and multiple myeloma cancer.
      • XPC gene mutations are associated with bladder and skin cancer.
    • Direct Reversal of Damage: Directly repairs certain types of DNA damage.
      • MGMT gene mutations are associated with colon, gastric, and glioblastoma cancer.
    • Mismatch Excision Repair (MMR): Repairs errors that occur during DNA replication.
      • Certain MMR proteins are associated with various types of cancer, including colorectal, endometrial, and gastric cancer.
    • Non-Homologous End Joining (NHEJ): Repairs double-strand DNA breaks.
      • XRCC5 gene mutations are associated with lung cancer.
      • BRCA1 gene mutations are associated with breast, ovarian, and gastric cancer.
    • Homologous Recombination (HR): A more accurate repair pathway for double-strand breaks that uses a homologous DNA template.
      • Mutations in HR genes, such as BRCA1 and BRCA2, increase the risk of breast and ovarian cancer.

    Conclusion:

    • Understanding the link between DNA repair systems and cancer development is crucial for developing effective cancer prevention and treatment strategies.
    • Targeting DNA repair pathways could be a potential approach for cancer therapy.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Description

    Explore the mechanisms of DNA repair systems and their critical role in genomic stability. Learn about specific pathways like base excision, direct reversal, non homologous end joining, and mismatch excision repair, along with their associations with various cancer types. This quiz will help deepen your understanding of the relationship between genetic mutations and cancer risks.

    More Like This

    DNA Repair Mechanisms Quiz
    36 questions
    DNA Damage and Repair Systems Quiz
    32 questions
    Use Quizgecko on...
    Browser
    Browser