DNA Repair Mechanisms Quiz
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DNA Repair Mechanisms Quiz

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Questions and Answers

What is the purpose of nucleotide excision repair?

  • To remove mis-incorporated bases during DNA replication
  • To correct thymine dimers induced by UV light (correct)
  • To synthesize and fill gaps in DNA strands
  • To recognize and cleave damaged strands

    • What is the name of the UV specific endonuclease that recognizes and cleaves the damaged strand?

  • Exonuclease 1
  • Ligase
  • uvrABC excinuclease (correct)
  • MutS

    • What is the purpose of mismatch repair?

  • To correct thymine dimers induced by UV light
  • To remove mis-incorporated bases during DNA replication (correct)
  • To synthesize and fill gaps in DNA strands
  • To recognize and cleave damaged strands

    • How many major proteins are involved in the MMR system in E. coli?

    <p>Three</p> Signup and view all the answers

    Which protein in the MMR system recognizes the mismatch and recruits MutL?

    <p>MutS</p> Signup and view all the answers

    What does MutH do in the MMR system?

    <p>Cuts the DNA strand flanking the mismatch</p> Signup and view all the answers

    What does Exonuclease 1 do in the MMR system?

    <p>Chews all the nucleotides that were cut and removed flanking mismatch nucleotide by endonuclease</p> Signup and view all the answers

    What does DNA polymerase III do in the MMR system?

    <p>Synthesizes and fills the gap</p> Signup and view all the answers

    What is the purpose of Ligase in the MMR system?

    <p>Seals the gap</p> Signup and view all the answers

    Which type of damage does nucleotide excision repair remove?

    <p>Thymine dimers induced by UV light</p> Signup and view all the answers

    Which protein recruits MutH in the MMR system?

    <p>MutL</p> Signup and view all the answers

    What happens after Ligase seals the gap in the MMR system?

    <p>The gap is synthesized and filled</p> Signup and view all the answers

    What is the purpose of nucleotide excision repair?

    <p>To correct thymine dimers induced by UV light</p> Signup and view all the answers

    What is the name of the UV specific endonuclease that recognizes and cleaves the damaged strand?

    <p>uvrABC excinuclease</p> Signup and view all the answers

    What is the purpose of mismatch repair?

    <p>To remove mis-incorporated bases during DNA replication</p> Signup and view all the answers

    How many major proteins are involved in the MMR system in E. coli?

    <p>Three</p> Signup and view all the answers

    Which protein in the MMR system recognizes the mismatch and recruits MutL?

    <p>MutS</p> Signup and view all the answers

    What does MutH do in the MMR system?

    <p>Cuts the DNA strand flanking the mismatch</p> Signup and view all the answers

    What does Exonuclease 1 do in the MMR system?

    <p>Chews all the nucleotides that were cut and removed flanking mismatch nucleotide by endonuclease</p> Signup and view all the answers

    What does DNA polymerase III do in the MMR system?

    <p>Synthesizes and fills the gap</p> Signup and view all the answers

    What is the purpose of Ligase in the MMR system?

    <p>Seals the gap</p> Signup and view all the answers

    Which type of damage does nucleotide excision repair remove?

    <p>Thymine dimers induced by UV light</p> Signup and view all the answers

    Which protein recruits MutH in the MMR system?

    <p>MutL</p> Signup and view all the answers

    What happens after Ligase seals the gap in the MMR system?

    <p>The gap is synthesized and filled</p> Signup and view all the answers

    What is the purpose of nucleotide excision repair?

    <p>To remove thymine dimers induced by UV light</p> Signup and view all the answers

    Which endonuclease is responsible for recognizing and cleaving the damaged strand during nucleotide excision repair?

    <p>uvrABC excinuclease</p> Signup and view all the answers

    What is the purpose of mismatch repair?

    <p>To correct mis-incorporated bases during DNA replication</p> Signup and view all the answers

    Which protein is responsible for recognizing the mismatch during MMR?

    <p>MutS</p> Signup and view all the answers

    What is the role of MutL during MMR?

    <p>To cut the DNA strand flanking the mismatch</p> Signup and view all the answers

    Which endonuclease cuts the DNA strand flanking the mismatch during MMR?

    <p>MutH</p> Signup and view all the answers

    What is the role of Exonuclease 1 during MMR?

    <p>To chew all the nucleotides that were cut and removed flanking mismatch nucleotide by endonuclease</p> Signup and view all the answers

    Which protein is responsible for synthesizing and filling the gap during MMR?

    <p>DNA polymerase III</p> Signup and view all the answers

    What is the purpose of ligase during MMR?

    <p>To seal the gap</p> Signup and view all the answers

    How many major proteins are involved in the MMR system in E. coli?

    <p>3</p> Signup and view all the answers

    What is the name of the endonuclease responsible for recognizing and cleaving the damaged strand during nucleotide excision repair?

    <p>uvrABC excinuclease</p> Signup and view all the answers

    Which repair system corrects mis-incorporated bases during DNA replication?

    <p>Mismatch repair</p> Signup and view all the answers

    Study Notes

    Nucleotide Excision Repair

    • Purpose: to remove DNA damage, specifically bulky lesions and UV-induced damage
    • Uses UV-specific endonuclease (UvrABC) to recognize and cleave the damaged strand
    • Removes helix-distorting DNA lesions, including UV-induced cyclobutane pyrimidine dimers

    Mismatch Repair

    • Purpose: to correct mis-incorporated bases during DNA replication
    • Involves 5 major proteins in E. coli: MutS, MutL, MutH, Exonuclease 1, and DNA polymerase III
    • MutS recognizes the mismatch and recruits MutL
    • MutH cuts the DNA strand flanking the mismatch
    • Exonuclease 1 removes the mismatched DNA strand
    • DNA polymerase III synthesizes and fills the gap
    • Ligase seals the gap
    • After Ligase seals the gap, the corrected DNA strand is restored

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    Description

    Test your knowledge on DNA repair mechanisms with this quiz! From nucleotide excision repair to mismatch repair, this quiz will challenge your understanding of how cells fix errors in DNA replication. Brush up on the key proteins and enzymes involved in these processes and discover new insights into the fascinating world of DNA repair. Perfect for biology students, researchers, and science enthusiasts.

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