18 Questions
What is the main goal of gene therapy?
To correct or compensate for diseases caused by defects and abnormal genes
What is the role of single nucleotide polymorphisms (SNPs) in the study related to common migraine?
Identification of genetic variations associated with common migraine
In the context of gene therapy, what is the purpose of introducing exogenous (normal) genes into target cells?
To compensate for the diseases caused by abnormal genes
Which technique shows great potential in the treatment of cancer, thalassemia, and hemophilia among others?
Gene therapy through exogenous gene introduction
What is the significance of structural variations in Alzheimer's disease and other neurodegenerative diseases?
Impact on disease development
How do single nucleotide polymorphisms (SNPs) contribute to understanding diseases like common migraine?
By identifying genetic variations associated with the disease
What method can be used for bi-allelic assays to detect DNA polymorphisms?
TaqMan Based Assay
In DNA polymorphism tests, what does the ratio of different fluorescence reporters indicate?
Alleles are homozygous wild type
Which of the following diseases can be detected using the RFLP method?
Sickle-Cell Anaemia
What is the full form of VNTR in the context of DNA polymorphism detection?
Variable Number Tandem Repeats
Which article title suggests an emerging role of VNTR in health and disease?
"Variable Number Tandem Repeats - Their Emerging Role in Sickness and Health"
Which technique is NOT typically used for detecting single nucleotide polymorphisms (SNPs)?
Western Blotting
What is the purpose of using fluorescent multiplex PCR in posttransplantation chimerism analysis?
To quantify the percentage of donor and recipient cells in the recipient's body
Which of the following DNA polymorphisms is the focus of studying how genomic variants influence health and disease?
Single nucleotide polymorphisms (SNPs)
Which method is used to detect a single nucleotide mismatch in traditional methods of DNA polymorphism detection?
Tm assay
What is the function of informative alleles in posttransplantation chimerism analysis using STR markers?
To identify the degree of chimerism
Which genetic marker is used to identify the sex of the individual in chimerism analysis?
Amelogenin
How does mismatch detection in DNA polymorphism analysis influence the stability of DNA duplexes?
Mismatched duplexes have lower stability than perfectly hybridized duplexes
Test your knowledge on DNA polymorphism detection methods, including bi-allelic assays using wt and mutation based probes, TaqMan based assay, and disease detection through DNA polymorphism tests.
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